Results 81 to 90 of about 11,262 (208)
Dependency of stable Nanog states on Nanog autoregulation and noise.
, 2014 (A) The bifurcation diagram indicates the existence of Nanog states depending on the autoregulatory transcription rate s4. The lower solid line shows the existence of Nanog-low (NL) states and the upper solid line shows the existence of Nanog-high (NH ...
Austin Smith (59569) +4 more
core +1 more source
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
Advanced Science, EarlyView.By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen +11 more
wiley +1 more source
Biotechnology & Biotechnological Equipment, 2019 Melatonin (MEL) may influence the efficiency of reprogramming both by somatic cell nuclear transfer and by direct induction of pluripotent stem cells (iPSC) through a yet unidentified mechanism. Transcription factors linked to cell reprogramming and cell
Georgi Nikolaev Georgiev +3 more
doaj +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Reprogramming of preiPSCs into iPSCs by Nanog+EV - GFP alone
, 2014 Video showing the kinetics of the emergence of Nanog-GFP+ colonies from Nanog+Mbd3 transgenic preiPSCs during a 12-day culture in 2i/LIF condition.
Rodrigo Santos (562993)
core +1 more source
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source
Reprogramming of preiPSCs into iPSCs by Nanog+Mbd3 - GFP alone
, 2014 Video showing the kinetics of the emergence of Nanog-GFP+ colonies from Nanog+Mbd3 transgenic preiPSCs during a 12-day culture in 2i/LIF condition.
Rodrigo Santos (562993)
core +1 more source
Advanced Science, EarlyView.Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang +9 more
wiley +1 more source
Functional analyses of NANOG in HL-60 cells.
, 2019 HL-60 cells were lentiviral transduced with NANOG (NANOG-1 and NANOG-2) or control vector (vector-1 and vector-2). Subsequent RQ-PCR analyses were performed for selected genes including (A) NKL homeobox genes, (B) transcription factors, (C) NOTCH-pathway
Corinna Meyer (146293) +8 more
core +1 more source