Results 101 to 110 of about 48,754 (252)
SHP-1 arrest early embryonic development via downregulated Nanog. [PDF]
, 2014 A–B: The mRNA of SHP-1(A) and Nanog (B) at precisely defined stages from the Zygote until the late blastocyst stage. C: Immunofluorescence was performed to detect SHP-1 and Nanog in mouse pre-implantation, each sample was counterstained with DAPI (blue ...
Xinying Wu (511870) +6 more
core +1 more source
Advanced Science, EarlyView.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source
Stem Cell Research & Therapy, 2020 Background NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a conserved pluripotency-associated ...
Junjun Xu +8 more
doaj +1 more source
Current Challenges of Transcription Compartmentalization Research
Advanced Science, EarlyView.Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley +1 more source
Journal of Dental Sciences, 2017 Background/purpose: Gingival overgrowth is a common side effect of medication with the immunosuppressant cyclosporine A (CsA). This study proposed to verify whether Nanog, an embryonic stem cell marker, contributes to gingival overgrowth stimulated with ...
Cheng-Chia Yu +5 more
doaj +1 more source
Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration
Advanced Science, EarlyView.Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang +5 more
wiley +1 more source
NANOG dynamics for mESC populations and single cells. [PDF]
, 2013 (A) Overall NANOG expression distribution in equilibrium. Three distinct peaks of low (‘L’), middle (‘M’) and high (‘H’) NANOG content are observed. (B) The distribution of NANOG at equilibrium taking into account transcriptional noise.
Emmanuel S. Tzanakakis (114570) +1 more
core +1 more source
Stem Cell Reports, 2018 Summary: Embryonic stem cells (ESCs) display heterogeneous expression of pluripotency factors such as Nanog when cultured with serum and leukemia inhibitory factor (LIF).
Simon Hastreiter +11 more
doaj +1 more source