Results 101 to 110 of about 11,262 (208)
Journal of Dental Sciences, 2017 Background/purpose: Gingival overgrowth is a common side effect of medication with the immunosuppressant cyclosporine A (CsA). This study proposed to verify whether Nanog, an embryonic stem cell marker, contributes to gingival overgrowth stimulated with ...
Cheng-Chia Yu +5 more
doaj +1 more source
Identification and characterisation of NANOG+/ OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines [PDF]
, 2018 Treatment of gestational trophoblastic diseases (GTD) involves surgery, radiotherapy and chemotherapy. Although, these therapeutic approaches are highly successful, drug resistance and toxicity remain a concern for high risk patients.
Coveney , Clare +29 more
core +1 more source
Advanced Science, EarlyView.This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu +15 more
wiley +1 more source
ZMYM2 inhibits NANOG-mediated reprogramming
Wellcome Open Research, 2019 Background: NANOG is a homeodomain-containing transcription factor which forms one of the hubs in the pluripotency network and plays a key role in the reprogramming of somatic cells and epiblast stem cells to naïve pluripotency.
Lawrence, Moyra +4 more
openaire +3 more sources
Quantitation of noise in NANOG expressed by hESCs.
, 2012 Total noise in NANOG expression profile (A) obtained by flow cytometry analysis of cultured hESCs and (B) as predicted by the model with gene expression noise set to zero.
Emmanuel S. Tzanakakis (114570) +1 more
core +1 more source
Advanced Science, EarlyView.When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu +5 more
wiley +1 more source
Heterogeneous NANOG expression by hESCs.
, 2012 (A) NANOG expression of hESCs measured by flow cytometry. Arbitrary units (AU) were converted to NANOG molecules per cell with the use of MESF beads (inset). (B) NANOG expression profiles of cultured hESCs at day 3, 4 and 5 after plating.
Emmanuel S. Tzanakakis (114570) +1 more
core +1 more source
Advanced Intelligent Systems, EarlyView.This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee +3 more
wiley +1 more source
, 2018 Figure S3. Parameter sensitivity analysis for the model. Illustration of the relative changes of the low-Nanog distribution ratio (blue bar), the average Oct4 level (green bar), and the average Nanog level of high-Nanog population (red bar).
Lei Zhang (38117) +3 more
core +1 more source