Results 121 to 130 of about 48,754 (252)

SUMOylation of Sox2 represses Nanog expression. [PDF]

, 2012
(A) Covalent modification of Sox2 by Sumo1 at Lysine 247. Wild-type Sox2 and mutant Sox2 K247R were coexpressed with HA-Sumo1 and HA-Ubc9. (B) qPCR analysis of Nanog mRNA in response to various levels of SUMOylated Sox2.
Lixia Yang (156282), Wenzhong Li (156311), Bo Tang (23472), Yong Zhang (5893), Zekun Guo (156269), Haibo Wu (156272), Juan Du (118107), Xiaohai Wang (156274), Liping Yang (156318), Yongyan Wu (156264), Xiaoyan Shi (156294)   +10 more
core   +1 more source

Role of Endothelial Nanog in Homeostasis of Adult Tissue Microenvironment [PDF]

, 2018
Elevated level of expression of transcription factor (TF) Nanog regulates pluripotency of stem cells. However, the biological significance of low-level expression of Nanog remains unknown.
Jugajyoti Baruah (3998135)
core   +2 more sources

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity [PDF]

, 2012
A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single cell level. The molecular basis for these fluctuations is unknown.
MacArthur, Ben D, Müller, Franz-Josef, Schuppert, Andreas A, Sevilla, Ana, Stumpf, Patrick S., Lemischka, Ihor R., Sonya J. Ridden, Wang, Jianlong, Schuldt, Bernhard, M., Lemischka, Ihor, R., Stumpf, Patrick S, Ridden, Sonya J., Lemischka, Ihor R, Ana Sevilla, Ihor R. Lemischka, Ben D. MacArthur, Lenz, Michel, Schuldt, Berhard M, Michel Lenz, Ridden, Sonya, J., Müller, Franz Josef, Berhard M. Schuldt, Miguel Fidalgo, Schuldt, Berhard M., MacArthur, Ben D., Ridden, Sonya J, Jianlong Wang, Andreas A. Schuppert, Lenz, Michael, Fidalgo, Miguel, Ma'ayan, Avi, Avi Ma’ayan, Stumpf, Patrick, S., Schuppert, Andreas, A., Schuppert, Andreas A., Schuppert, Andreas, Franz-Josef Müller, Patrick S. Stumpf   +37 more
core   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Germ cell restricted expression of chick Nanog [PDF]

, 2013
Nanog is a pluripotency-associated factor expressed in embryonic stem cells and in the epiblast and primordial germ cells of the mouse embryo. We have identified the chick orthologue of Nanog and found that its expression is limited to primordial germ ...
Herranz, Cristina, Manzanares, Miguel, Cañón, Susana   +2 more
core   +1 more source

β-Catenin Fluctuates in Mouse ESCs and Is Essential for Nanog-Mediated Reprogramming of Somatic Cells to Pluripotency

Cell Reports, 2014
The Wnt/β-catenin pathway and Nanog are key regulators of embryonic stem cell (ESC) pluripotency and the reprogramming of somatic cells. Here, we demonstrate that the repression of Dkk1 by Nanog, which leads indirectly to β-catenin activation, is ...
Lucia Marucci, Elisa Pedone, Umberto Di Vicino, Blanca Sanuy-Escribano, Mark Isalan, Maria Pia Cosma   +5 more
doaj   +1 more source

NANOG in ovarian cancer

, 2012
published_or_final_version ; Pathology ; Master ; Master of Medical ...
openaire   +2 more sources

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

NANOG regulates epithelial-mesenchymal transition and chemoresistance in ovarian cancer [PDF]

, 2017
Synopsis A key transcription factor associated with poor prognosis and resistance to chemotherapy in ovarian cancer is NANOG. However, the mechanism by which NANOG functions remains undefined.
Xuexia Cao, Shan Qin, Yanfang Li, Jiexian Du, Xianghua Huang   +4 more
core