Results 111 to 120 of about 11,262 (208)

Histological Characterization and Comparative Transcriptomic Analysis of Gonads During Early Sex Differentiation in the Northern Snakehead (Channa argus)

Animal Research and One Health, EarlyView.
This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun, Donglei Sun, Haishen Wen, Xin Qi, Chao Li, Xiaoyan Zhang, Yun Li   +6 more
wiley   +1 more source

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal [PDF]

, 2013
Embryonic stem (ES) cell self-renewal efficiency is determined by the Nanog protein level. However, the protein partners of Nanog that function to direct self-renewal are unclear.
Halbritter, Florian, Kousa, Anastasia I, Gagliardi, A, Chambers, Ian, Tomlinson, SR, Tomlinson, Simon R, Kousa, AI, Weiss, Jason T, Ying Tan, Zi, Demmers, Jeroen, Colby, D, Favaro, Rebecca, Ying Tan, Z, Poot, Raymond, Favaro, R, Colby, Douglas, Halbritter, F, Nicolis, SK, Felker, A, Poot, Raymond A, Gagliardi, Alessia, Mullin, NP, Nicolis, Silvia K, Weiss, JT, Chambers, I, Mullin, Nicholas P, Felker, Anastasia, Bezstarosti, Karel   +27 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Inductive and Selective Effects of GSK3 and MEK Inhibition on Nanog Heterogeneity in Embryonic Stem Cells

Stem Cell Reports, 2018
Summary: Embryonic stem cells (ESCs) display heterogeneous expression of pluripotency factors such as Nanog when cultured with serum and leukemia inhibitory factor (LIF).
Simon Hastreiter, Stavroula Skylaki, Dirk Loeffler, Andreas Reimann, Oliver Hilsenbeck, Philipp S. Hoppe, Daniel L. Coutu, Konstantinos D. Kokkaliaris, Michael Schwarzfischer, Konstantinos Anastassiadis, Fabian J. Theis, Timm Schroeder   +11 more
doaj   +1 more source

Quantitative mass spectrometry analysis of NANOG partner proteins

The transcription factor NANOG is a dose-dependent regulator of mouse embryonic stem cell (ESC) self-renewal. The interaction of NANOG with partner proteins is thought to regulate self-renewal.
Cha, Chonghyun
core   +1 more source

Viscoelastic hydrogel potentiates cancer cell stemness and drug resistance through Piezo1‐dependent mechanotransduction

BMEMat, EarlyView.
The effects of matrix dynamics on cancer progression remain unclear. Herein, we fabricated a tunable dynamic hydrogel via reversible host–guest crosslinking and demonstrated that high matrix dynamics activate Piezo1 and its downstream PI3K/AKT and Wnt/β‐catenin signaling pathways, thereby enhancing cancer spheroid assembly, elevating cancer stemness ...
Yi Liu, Huiyao Deng, Hanlei Zhang, Chutian Huang, Huolun Feng, Xiayi Xu, Heemin Kang, Meiling Zhu, Liming Bian, Kunyu Zhang   +9 more
wiley   +1 more source

Characterization of Cancer Stem Cells in Moderately Differentiated Buccal Mucosal Squamous Cell Carcinoma

Frontiers in Surgery, 2016
Aim To identify and characterize cancer stem cells (CSC) in moderately differentiated buccal mucosa squamous cell carcinoma (MDBMSCC). Methods 4μm-thick formalin-fixed paraffin-embedded MDBMSCC samples from six patients underwent 3,3-diaminobenzidine ...
Helen H Yu, Therese Featherston, Swee T Tan, Alice Margaret Chibnall, Helen D Brasch, Paul F Davis, Tinte Itinteang   +6 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

GLI2 and NANOG in epithelial ovarian cancer: molecular pathways driving carboplatin resistance

All Life
This review reveals the molecular mechanism by which the Hedgehog (Hh) signaling effector Gli2 promotes carboplatin resistance in epithelial ovarian cancer (EOC) through regulating the core stem cell transcription factor NANOG. Studies indicate that Gli2
Yinghua Yu, Huifang Yan, Xiaohui Mei, Rong Xu   +3 more
doaj   +1 more source

NANOG in ovarian cancer

, 2012
published_or_final_version ; Pathology ; Master ; Master of Medical ...
openaire   +2 more sources