Results 131 to 140 of about 48,754 (252)
Reporter and endogenous NANOG protein levels under different conditions. [PDF]
, 2013 (A) Observed NANOG reporter (GFP) expression level in stem cells with a single-allele insertion of the gfp. The expression levels of NANOG and the reporter are shown assuming the same t1/2 (2 hours) for the reporter and NANOG and the reporter gene ...
Emmanuel S. Tzanakakis (114570) +1 more
core +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho +7 more
wiley +1 more source
Allergy, EarlyView.Patient‐derived expanded potential stem cell (EPSC) hepatocytes reveal that pathogenic SERPING1 variants cause distinct cellular defects in hereditary angioedema. While most mutations reduce SERPING1 transcription and C1‐INH secretion, a large deletion induces intracellular C1‐INH retention.
Xueyan Liu +10 more
wiley +1 more source
Dynamic control of Nanog expression in embryonic stem cells [PDF]
, 2011 Embryonic stem cells are defined by two key characteristics; apparently symmetrical self-renewing cell division and the ability to differentiate into cells of all three germ layers. Self-renewal depends on several extrinsic and intrinsic cues including
Karwacki-Neisius, Violetta Anna +1 more
core
BRD9 inhibition as potential treatment option for testicular germ cell tumors
Andrology, EarlyView.Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen +5 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
장액성 난소암에서 NANOG 발현의 예후적 중요성에 관한 연구 [PDF]
, 2012 Dept. of Medicine/석사NANOG, a key transcription factor in embryonic stem cell self-renewal and pluripotency, plays an important role in solid tumor development.
이마리아
core
Andrology, EarlyView.ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz +12 more
wiley +1 more source
A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics
Andrology, EarlyView.ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis +3 more
wiley +1 more source
Quantitative mass spectrometry analysis of NANOG partner proteins [PDF]
The transcription factor NANOG is a dose-dependent regulator of mouse embryonic stem cell (ESC) self-renewal. The interaction of NANOG with partner proteins is thought to regulate self-renewal.
Cha, Chonghyun
core +1 more source