Results 131 to 140 of about 70,422 (295)
Cell Proliferation, EarlyView.The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang +11 more
wiley +1 more source
High NANOG expression correlates with worse patients’ survival in esophageal adenocarcinoma [PDF]
, 2023 Karl Knipper +8 more
openalex +1 more source
Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling
Cell Proliferation, EarlyView.BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou +8 more
wiley +1 more source
Cell Reports, 2014 The Wnt/β-catenin pathway and Nanog are key regulators of embryonic stem cell (ESC) pluripotency and the reprogramming of somatic cells. Here, we demonstrate that the repression of Dkk1 by Nanog, which leads indirectly to β-catenin activation, is ...
Lucia Marucci +5 more
doaj +1 more source
, 2012 published_or_final_version ; Pathology ; Master ; Master of Medical ...
openaire +2 more sources
Light‐Inducible Activation of FGFR3 Facilitates Chondrocyte Maturation
Cell Proliferation, EarlyView.Light‐inducible activation of FGFR3 induced robust activation of MAPK signaling, promoting proliferation and collagen depositon in induced chondrocytes and prevent the degeneration of osteoarthritic chondrocytes.
Mengze Sun +5 more
wiley +1 more source
Tracing blastomere fate choices of early embryos in single cell culture [PDF]
, 2010 Blastomeres of early vertebrate embryos undergo numerous fate choices for division, motility, pluripotency maintenance and restriction culminating in various cell lineages.
Chang Ming Li +11 more
core +1 more source
Cell Proliferation, EarlyView.CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh +4 more
wiley +1 more source
Micelle-like clusters in phase-separated Nanog condensates: A molecular simulation study
, 2023 Azuki Mizutani +3 more
openalex +2 more sources
Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens
Cell Proliferation, EarlyView.In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu +8 more
wiley +1 more source