Results 141 to 150 of about 48,754 (252)
Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines
Andrology, EarlyView.ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede +11 more
wiley +1 more source
Cell Proliferation, EarlyView.The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang +11 more
wiley +1 more source
Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling
Cell Proliferation, EarlyView.BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou +8 more
wiley +1 more source
Cell Proliferation, EarlyView.CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh +4 more
wiley +1 more source
Avaliação do potencial de diferenciação das células da polpa dentária de humanos [PDF]
, 2010 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.O desenvolvimento dentário ocorre através de interações sequenciais entre o epitélio oral e o mesênquima.
Beatriz Dal Pont, Duarte
core
Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens
Cell Proliferation, EarlyView.In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu +8 more
wiley +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Inflammation‐Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF‐κB Crosstalk
International Endodontic Journal, EarlyView.ABSTRACT Background Inflammation critically determines dental pulp regenerative outcomes, with dental pulp stem cells (DPSCs) orchestrating tissue homeostasis through differentiation, self‐renewal and immunomodulation processes dynamically regulated by Wnt/β‐catenin and NF‐κB signaling crosstalk.
V. Rajasekar +4 more
wiley +1 more source
20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy
Journal of Microscopy, EarlyView.Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford +3 more
wiley +1 more source