Results 151 to 160 of about 11,262 (208)
Derivation of Mouse Dome‐Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts
Cell Proliferation, EarlyView.Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Minli Liu +8 more
wiley +1 more source
Diabetic Medicine, EarlyView.Abstract Aims Stem cell‐derived islets (SC‐islets) offer the potential to revolutionise type 1 diabetes treatment. However, functional maturation in vivo is variable, suggesting that specific, but as‐yet undefined, environmental cues are critical. We aimed to identify pathways associated with SC‐islet in vivo maturation in mice, assess early functional
Rosie Sullivan +12 more
wiley +1 more source
RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms
The FEBS Journal, EarlyView.RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon +4 more
wiley +1 more source
20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy
Journal of Microscopy, EarlyView.Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford +3 more
wiley +1 more source
Journal of Periodontal Research, EarlyView.A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed +6 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.DE‐CQ, an NAD(P)H‐activatable theranostic probe, enables the quantification of cancer aggressiveness via glucose‐stimulated fluorescence imaging and selectively induces apoptosis. Its multifaceted efficacy is demonstrated across 2D cells, 3D spheroids, and in vivo models.
Yujin Cha +11 more
wiley +2 more sources
Mapping the Bioenergetic Landscape of Oral Cancer Stem Cells: A Systematic Review
Oral Diseases, EarlyView.ABSTRACT Objectives Oral squamous cell carcinoma (OSSC) remains highly lethal, with resistance largely driven by cancer stem cells (CSCs). Mitochondrial reprogramming supports CSC redox control, self‐renewal, and survival. This systematic review aimed to synthesize mitochondrial mechanisms sustaining CSCs in OSCC and evaluate their therapeutic ...
Rodrigo Elísio de Sá +6 more
wiley +1 more source
Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism
, 2010 Early lineage segregation in mouse development results in two, either CDX2- or OCT4/NANOG-positive, cell populations. CDX2-positive cells form the trophectoderm (TE), OCT4/NANOG-positive cells the inner cell mass (ICM).
Messerschmidt, D., Kemler, R.
core
Oral Ulcerations and Phytotherapy: Potential Role of Helichrysum Essential Oil—A Literature Review
Oral Diseases, EarlyView.ABSTRACT Background Recurrent aphthous stomatitis (RAS) is a common yet therapeutically challenging chronic inflammatory disease of the oral mucosa, characterized by recurrent, painful ulcerations that substantially affect patients' quality of life. Objective This review summarizes current evidence on phytotherapy in RAS, with particular focus on the ...
Ruzica Ivkovic +4 more
wiley +1 more source