Results 51 to 60 of about 48,754 (252)
The pluripotency rheostat Nanog functions as a dimer [PDF]
Biochemical Journal, 2008 The defining activity of the homeodomain protein Nanog is the ability to confer cytokine-independent self-renewal upon ES (embryonic stem) cells in which it is overexpressed. However, the biochemical basis by which Nanog achieves this function remains unknown. In the present study, we show that Nanog dimerizes through a functionally critical domain. Co-
Nicholas P, Mullin +7 more
openaire +2 more sources
Nanog Heterogeneity: Tilting at Windmills? [PDF]
Cell Stem Cell, 2013 Fluctuating expression of transcription factors in embryonic stem cells is an alluring observation, but, as outlined by two articles in this issue, appearances can be misleading.
openaire +2 more sources
Dependency of stable Nanog states on Nanog autoregulation and noise. [PDF]
, 2014 (A) The bifurcation diagram indicates the existence of Nanog states depending on the autoregulatory transcription rate s4. The lower solid line shows the existence of Nanog-low (NL) states and the upper solid line shows the existence of Nanog-high (NH ...
Austin Smith (59569) +4 more
core +1 more source
miR-133a-3p and miR-145-5p co-promote goat hair follicle stem cell differentiation by regulating NANOG and SOX9 expression [PDF]
Animal BioscienceObjective Hair follicle stem cells (HFSCs) differentiation is a critical physiological progress in skin hair follicle (HF) formation. Goat HFSCs differentiation is one of the essential processes of superior-quality brush hair (SQBH) synthesis.
Jian Wang +6 more
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyIntroductionThe safe and effective application of human pluripotent stem cells (hPSCs) in research and regenerative medicine requires precise control over pluripotency and cell fate.
Petr Fojtík +23 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundCancer stem cells (CSCs) and Circulating tumor cells (CTCs) have been proposed as fundamental causes for the recurrence of hepatocellular carcinoma (HCC).
Yongrong Lei +7 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.ABSTRACT Quantitative characterization of vascular heterogeneity in complex microphysiological systems (MPS), particularly within patient‐derived tumor microenvironments, remains a major challenge for scalable disease modeling and therapeutic evaluation.
Jungseub Lee +9 more
wiley +1 more source
Esrrb is a prominent target of Nanog that substitutes for Nanog function in ES cell self-renewal, reprogramming and germline development [PDF]
, 2013 Embryonic stem (ES) cell pluripotency is sustained by a network of transcription factors centred on Oct4, Sox2 and Nanog. Whilst Oct4 and Sox2 expression is relatively uniform, ES cells fluctuate between states of high Nanog expression possessing high
Festuccia, Nicola
core
STAT3 binds to Nanog promoter and activates Nanog transcription. [PDF]
, 2014 (A) ChIP assay was performed to confirm the binding of STAT3 to specific region of Nanog promoter. (B) ChIP in the presence of SHP-1 overexpression is also preformed. Overexpress SHP-1 can decrease the level of STAT3 binds to the Nanog promoter. (C): The
Xinying Wu (511870) +6 more
core +1 more source