Results 51 to 60 of about 11,262 (208)

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells

Stem Cell Reports, 2017
Of the thousands of long noncoding RNAs expressed in embryonic stem cells (ESCs), few have known roles and fewer have been functionally implicated in the regulation of self-renewal and pluripotency, or the reprogramming of somatic cells to the ...
Keriayn N. Smith, Joshua Starmer, Sarah C. Miller, Praveen Sethupathy, Terry Magnuson   +4 more
doaj   +1 more source

SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. [PDF]

PLoS ONE, 2012
Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog
Yongyan Wu, Zekun Guo, Haibo Wu, Xiaohai Wang, Lixia Yang, Xiaoyan Shi, Juan Du, Bo Tang, Wenzhong Li, Liping Yang, Yong Zhang   +10 more
doaj   +1 more source

The pluripotency rheostat Nanog functions as a dimer [PDF]

Biochemical Journal, 2008
The defining activity of the homeodomain protein Nanog is the ability to confer cytokine-independent self-renewal upon ES (embryonic stem) cells in which it is overexpressed. However, the biochemical basis by which Nanog achieves this function remains unknown. In the present study, we show that Nanog dimerizes through a functionally critical domain. Co-
Nicholas P, Mullin, Adam, Yates, Arthur J, Rowe, Bianca, Nijmeijer, Douglas, Colby, Paul N, Barlow, Malcolm D, Walkinshaw, Ian, Chambers   +7 more
openaire   +2 more sources

Mutant Nanog simulations.

, 2023
(A–C) Simulation results for the Nanog mutant W8A. (A) Time course of 200 Nanog molecules along the z-axis (long axis) of the slab. (B) Snapshot at the end of the simulation. (C) Density of amino acids along the z-axis. Yellow, W8A; blue, WT.
Cheng Tan (293674), Shoji Takada (282002), Yuji Sugita (140032), Azuki Mizutani (16641714)   +3 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Human papillomavirus (HPV) genotyping and prognostic value of HPV E4 protein and transcription factors NANOG and SOX11 in atypical p16 patchy squamous epithelium of cervix

Radiology and Oncology
Immunohistochemical staining for p16 is used to differentiate precancerous cervical lesions in tissue samples, but the interpretation of patchy p16 expression remains challenging.
Radulovic Maja Kebe, Ostrbenk Anja, Poljak Mario, Strojan-Flezar Margareta   +3 more
doaj   +1 more source

Transcription factor Six2 induces a stem cell‐like phenotype in renal cell carcinoma cells

FEBS Open Bio, 2019
Renal cell carcinoma (RCC) accounts for 2–3% of adult malignant tumors, and the incidence of RCC worldwide has increased by about 2% over the past two decades.
Na Cheng, Hongjuan Li, Yan Han, Shuzhen Sun   +3 more
doaj   +1 more source

Analysis of topological properties of NANOG-miRNA-targets in human PPINs.

, 2014
(A) Comparison of NANOG-miRNA and NANOG-non-miRNA targets. (B) Comparison of NANOG-miRNA and non-NANOG-non-miRNA targets.
Liangcai Zhang (156659), Jinlian Hua (182220), Shihua Zhang (21549), Guiyou Liu (224712), Lei Yang (102719), Yongshuai Jiang (194259), Rennan Feng (186785), Mingzhi Liao (473967), Leijie Li (623371)   +8 more
core   +1 more source