Results 111 to 120 of about 54,485 (283)
Oct4: the final frontier, differentiation defining pluripotency
, 2013 The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4’s major early activity in
Brickman, Joshua M, Livigni, Alessandra
core +1 more source
Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog [PDF]
, 2013 Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered on the transcription factors Oct4 and Nanog. To date, robust self-renewing ESC states have only been obtained through the chemical inhibition of signaling pathways ...
Halbritter, Florian +27 more
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BMEMat, EarlyView.The effects of matrix dynamics on cancer progression remain unclear. Herein, we fabricated a tunable dynamic hydrogel via reversible host–guest crosslinking and demonstrated that high matrix dynamics activate Piezo1 and its downstream PI3K/AKT and Wnt/β‐catenin signaling pathways, thereby enhancing cancer spheroid assembly, elevating cancer stemness ...
Yi Liu +9 more
wiley +1 more source
Post-translational modification of OCT4 in breast cancer tumorigenesis [PDF]
, 2018 Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer.
강혁구, 전경희, 안성귀
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Oncology Reports, 2015 OCT4 plays a critical role in the maintenance of stem cell pluripotency and proliferation, and is overexpressed in multiple human tumors, including endometrial cancer. OCT4 expression can be modulated by miR-145 and the OCT4 pseudogene 5 (OCT4-pg5), which share similar binding sites in the OCT4 3'-untranslated region.
Mingzhu, Bai +9 more
openaire +3 more sources
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Identification and Characterization of the OCT4 Upstream Regulatory Region in Sus scrofa
Stem Cells International, 2019 OCT4 plays pivotal roles in maintaining pluripotency during early mammalian embryonic development and in embryonic stem cells. It is essential to establish a reporter system based on the OCT4 promoter region to study pluripotency. However, there is still
Seung-Hun Kim +5 more
doaj +1 more source
, 2013 All embryos transferred to a surrogate and depicted or described in panels A–E were induced with tamoxifen ∼E6.0 and ∼E6.5 to compensate for the variability in developmental timing associated with transfer (Table S1Q,AB). Scale bars in panels A–D are 200
Andras Nagy (58911) +11 more
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Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation
iNew Medicine, EarlyView.The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li +11 more
wiley +1 more source
eLife, 2016 Pluripotency transcription programs by core transcription factors (CTFs) might be reset during M/G1 transition to maintain the pluripotency of embryonic stem cells (ESCs). However, little is known about how CTFs are governed during cell cycle progression.
Jihoon Shin +12 more
doaj +1 more source