Results 121 to 130 of about 43,496 (227)

The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
We found that SOCS3 deficiency activates STAT3 to enhance glioma stem cell (GSC) stemness and survival. We demonstrated that IL‐6 rescues STAT3 signaling and reverses SOCS3‐mediated tumor suppression. We revealed that SOCS3‐low GSCs exhibit enriched p53 and JAK‐STAT pathway activity. This study provides new mechanistic insights into SOCS3‐STAT3 axis in
Jingtao Wang, Gaolei Hou, Zhaofei Song, Kai Gao, Hongbin Wang, Tao Li   +5 more
wiley   +1 more source

Navigating Human Astrocyte Differentiation: Direct and Rapid One‐Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development

Glia, Volume 74, Issue 9, September 2026.
One‐step protocol enabling direct differentiation of human iPSCs into functional astrocytes within 5 weeks. Validated in > 60 lines across 10 labs. iPSC‐astrocytes support robust neuronal network development in co‐culture. ABSTRACT Astrocytes play a pivotal role in neuronal network development.
Imke M. E. Schuurmans, Annika Mordelt, Marta Guevara‐Ferrer, Katrin Linda, Denise Duineveld, Sofia Puvogel, Marina P. Hommersom, Nicky Scheefhals, Lisa Rahm, Emma Dyke, Gijs‐Jan Scholten, Caroline Knorz, Carlos Gonzalez Jimenez, Noelle van Egmond, Astrid Oudakker, Chantal Bijnagte‐Schoenmaker, Hans van Bokhoven, Wei Wei, Samuel Hofmann, Sabine Jung‐Klawitter, Sandra Mojica‐Perez, Jack Parent, Lidia Carotenuto, Sarah Weckhuysen, Nadine Maas, Ype Elgersma, Eline van de Ven, Dirk Lefeber, Anita Lygeroudi, Helga E. de Vries, Luc Jordi, Magdalini Polymenidou, Teresa Mitchell‐Garcia, Iulia Dragan, Amalia Dolga, Lot D. de Witte, Clara D. M. van Karnebeek, James Ellis, Alejandro Garanto, Nael Nadif Kasri   +39 more
wiley   +1 more source

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, Volume 14, Issue 6, Page 1579-1589, September 2026.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source

Focused Ultrasound‐Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri‐Focally Localized Glioblastoma Cells

International Journal of Cancer, Volume 159, Issue 4, Page 1005-1016, 15 August 2026.
Glioblastoma (GBM) is highly aggressive and therapy‐resistant, warranting exploration of novel treatment strategies, among them mechanical high‐intensity focused ultrasound (mFUS), which holds significant promise for tumor ablation. The present study examined mFUS‐induced changes specifically in carbohydrate metabolism, which affects vulnerability to ...
Frieda Bayler, Jonna Holler, Jacqueline Clüver, Levi Johanning, Dana Hellmold, Nils Oliver Schröder, Jessica Nojszewski, Hajrullah Ahmeti, Carolin Kubelt‐Kwamin, Michael Synowitz, Janka Held‐Feindt   +10 more
wiley   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

OCT 4 immunohistochemistry in postpubertal cryptorchidism

Open Medicine, 2011
Krhen Ivan, Kulis Tomislav, Coric Marijana, Knezevic Nikola, Marekovic Zvonimir, Kastelan Zeljko   +5 more
doaj   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, Volume 4, Issue 3, Page 347-351, August 2026.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. Intrinsic and acquired resistance to TMZ, including MGMT‐dependent DNA repair and activation of pro‐survival pathways ...
Ali Nakhaei, Atefeh Taghavi, Amir R. Afshari, Farzaneh Davoudi, Elaheh Gheybi, Mohammad Jalili‐Nik   +5 more
wiley   +1 more source

CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
We generated retinal organoids from a patient with USH3A and performed single‐cell RNA sequencing. CLRN1 was specifically expressed in Müller cells, where its variants led to mitochondrial dysfunction and photoreceptor degeneration. ABSTRACT Background Usher syndrome 3A (USH3A), caused by mutations in the CLRN1 gene, leads to retinitis pigmentosa and ...
Rui Zhang, Xinbo Ji, Han Yu, Jingwen Xu, Yu Wang, Ping Sun, Yingxin Wang, Yao Tang, Zexin Zhan, Yichang Jiao, Didi Shan, Pengfei Lin, Dong‐dong Wang, Yuying Zhao, Xianyang Liu, Chuanzhu Yan, Jianqiao Li, Mingfeng Li, Fuchen Liu, Shengping Hou   +19 more
wiley   +1 more source

A peripheral blood-based approach involving vimentin along with AURKA enabled efficient tracking of elusive Oct4/Sox2-expressing disseminated breast cancer stem cells. [PDF]

Biosci Rep
Sengupta D, Thakur D, Mahapatra E, Das S, Chakrabarti J, Sen S, Mukherjee S.   +6 more
europepmc   +1 more source