Results 141 to 150 of about 54,485 (283)

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Stability of Oct4/Sox2^0bp and Oct4/Sox2^3bp complexes.

, 2016
(A) Root mean square deviations (RMSDs) were performed for backbone atoms, with respect to the initial structure, to attain their equilibrium positions and maintain the relaxed state throughout the simulation.
Masaud Shah (390960), Muhammad Ayaz Anwar (780436), Dhanusha Yesudhas (847724), Sangdun Choi (122038), Suresh Panneerselvam (5666563), Prasannavenkatesh Durai (122034)   +5 more
core   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Effects of Oct4-targeting morpholinos on early development.

, 2013
(A) Blastocyst development following electroporation of zygotes with customized Oct4 morpholinos at different concentrations and cultured for 3.5 d.
Yong Zhang (5893), Hui Peng (116756), Yongyan Wu (156264)   +2 more
core   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Controlling Oct4 Expression Levels Using Invitrogen’s GeneSwitch™ System [PDF]

, 2018
Oct4 is a transcription factor that is crucial for the induction and retention of pluripotency in pluripotent stem cells. The potential for Oct4 to regulate the developmental potency of multipotent stem cells like adipose-derived mesenchymal stem cells ...
Leggins, Autumn S
core  

Bioinformatics Analyses of Oct4 Pseudogenes

International Journal of Translational Science
Oct4 is among the key genes involved in pluripotency. Oct4, through alternative splicing, produces at least three different transcripts, Oct4a, Oct4b, and Oct4b1. The Oct4a transcript has been focused on due to its role in pluripotency and multipotency of stem cells. There are several Oct4 pseudogenes with at least seven identified in the human genome.
Anna Pang, Leah King, Zachary Jaloudi, Elisa Gubenko, Nneka Arinzeh, Anvi S. Bhatt, Lauren S. Sherman   +6 more
openaire   +1 more source

Repurposed catechol‐O‐methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models

British Journal of Pharmacology, EarlyView.
Background and purpose Pathogenic aggregation and propagation of seed‐competent TAU assemblies drive tauopathies. MAPT P301 mutations accelerate aggregation and enhance seed competence, yet pharmacological strategies selectively targeting these pathogenic species remain limited.
Ihor Kozlov, Yu‐Sheng Hung, Sudeep Roy, Alladi Charanraj Goud, Roman Kouřil, Yu‐Hui Wong, Viswanath Das   +6 more
wiley   +1 more source

Musashi‐1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model

Cancer Science, EarlyView.
Fractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park   +5 more
wiley   +1 more source

Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway

, 2010
Chemoresistance presents a major obstacle to the efficacy of chemotherapeutic treatment of cancers. Using chemotherapeutic drugs to select drug-resistant cancer cells in hepatocellular carcinoma (HCC) and several other cancer cell lines, we demonstrate ...
Ronnie T.P. Poon, Lin Chen, Weg M. Ongkeko, Wang, XQ, Sheung Tat Fan, Kwok Kin Chen, Ping Lu, Lopez, JP, Chen, KK, Chen, L, Ongkeko, WM, Fan, ST, Zhen Fan Yang, Poon, RTP, Lu, P, Yang, ZF, Jay P. Lopez, Xiao Qi Wang   +17 more
core   +1 more source