Results 141 to 150 of about 43,496 (227)

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, Volume 59, Issue 8, August 2026.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

The Small Chemical Compound Repsox Potentiates Oct4-Driven Astrocyte-to-Neural Stem Cell Reprogramming via Notch1/Hes1/Smurf2 Pathway. [PDF]

Cell Mol Neurobiol
Ma X, Liu Z, He Y, Zhang D, Deng P, Li L, Li X, Li J, Ma Q, Yang H.   +9 more
europepmc   +1 more source

AID‐Mediated Protein Knockdown Reveals the Requirement of NANOS2 in Prenatal Gonocytes for Establishing Functional Spermatogonial Stem Cells

Development, Growth &Differentiation, Volume 68, Issue 6, August 2026.
ABSTRACT The RNA‐binding protein NANOS2 plays a crucial role in male gonocyte development and the maintenance of spermatogonial stem cells. In the absence of the Nanos2 gene (Nanos2‐KO), germ cells fail to enter G0 arrest and initiate the male differentiation program (including DNA methylation and the piRNA pathway), ultimately undergoing apoptosis ...
Yumiko Saga, Quan Wu
wiley   +1 more source

OCT4 and NANOG are involved in adrenocortical tumorigenesis. [PDF]

Arch Endocrinol Metab
Cavalcanti MM, Halah MP, Leal LF, Coeli-Lacchini FB, Scrideli CA, Molina CAF, Yunes JA, Brandalise S, Moreira AC, Ramalho F, Ramalho LN, Castro M, Antonini SR.   +12 more
europepmc   +1 more source

Immunophenotypic assessment of pure embryonal carcinoma and yolk sac tumour suggests that reprogramming to non‐seminoma occurs outside the spermatogonial niche

Histopathology, Volume 89, Issue 2, Page 303-311, August 2026.
Immunohistochemical analysis of transcription factors in GCNIS associated with pure EC and YST suggests that reprogramming to non‐seminoma occurs outside the spermatogonial niche. In these tumors, reprogramming may occur immediately upon invasion of the stroma or within seminiferous tubules but outside the spermatogonial niche (i.e., in intratubular ...
Daisy Maharjan, Květoslava Michalová, Joao Lobo, Jennifer Gordetsky, Fiona MacLean, Ankur R Sangoi, Daniel Berney, Chia‐Sui Kao, Costantino Ricci, Adeboye O Osunkoya, Maria Rosaria Raspollini, Geert JLH van Leenders, Muhammad T Idrees, Lee Ann Baldridge, Thomas M Ulbright, Andres M Acosta   +15 more
wiley   +1 more source

Expression of HSP70, IGF-1, OCT4, and AIF in Clear Cell Renal Cell Carcinoma. [PDF]

Biomedicines
Franić MB, Todorović P, Sedlar IT, Filipović N, Kelam N, Racetin A, Kopilaš A, Huljev AD, Vukojević K.   +8 more
europepmc   +1 more source

Diagnostic Challenges in Choroid Plexus Tumours

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
In this review, we summarise the diagnostic spectrum of choroid plexus tumours, highlight key age‐dependent differential diagnoses across infants, children/adolescents and adults, and outline how histopathology, immunohistochemistry and molecular profiling support accurate tumour classification.
Christian Thomas, Martin Hasselblatt
wiley   +1 more source

Harnessing the murine inner cell mass mechanical environment enhances derivation of in vitro nascent primitive endoderm precursor cells. [PDF]

Development
Corujo-Simon E, Salomaa SI, Bates LE, Yanagida A, Mansfield W, Becher H, Nichols J, Chalut KJ.   +7 more
europepmc   +1 more source

Deregulation of stemness and senescence genes in bone marrow mesenchymal stem cells of multiple myeloma: implications for therapeutic approaches. [PDF]

Blood Res
Soleymani F, Kavousi S, Khodakarim N, Ahmadvand M.   +3 more
europepmc   +1 more source

The FAP+ CAF subset in bladder cancer: A key driver of cancer cell stemness and a promising target for FAPI therapy

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Meiqian Li, Shikun Wang, Hua Xiao, Rong Hu, Yueyun Xie   +4 more
wiley   +1 more source