Results 151 to 160 of about 54,485 (283)

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

Derivation of Mouse Dome‐Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts

Cell Proliferation, EarlyView.
Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Minli Liu, Shaofang Ren, Xinyu Xia, Guanlin Lu, Haojie Yang, Yi Zheng, Jiexiang Zhao, Xiao‐Yang Zhao, Mei Wang   +8 more
wiley   +1 more source

OCT4 Accelerates Tumorigenesis Through Activating JAK/STAT Signaling in Ovarian Cancer Side Population Cells [Retraction]

Cancer Management and Research
Ruan Z, Yang X, Cheng W. Cancer Manag Res. 2019;11:389–399. We, the Editors and Publisher of Cancer Management and Research, have retracted the following article.
Ruan Z, Yang X, Cheng W
doaj  

No Female Germline Stem Cells Were Identified by Advanced Dual Recombinase‐Based Lineage Tracing System

Cell Proliferation, EarlyView.
Schematic summary of the dual‐recombinase lineage tracing strategies to determine whether female germline stem cells (fGSCs) exist and sustain the ovarian follicle pool in adult female mice. Our study concluded that no fGSCs exist and contribute to oocyte regeneration in adult female mice with different tracing systems. ABSTRACT Whether female germline
Yang Gao, Zhiming Shen, Xiuhong Cui, Min Chen, Mengyue Wang, Kui Liu, Fei Gao, Hongmei Wang   +7 more
wiley   +1 more source

K132 is important for OCT4 chromatin association after CoCl₂ treatment.

, 2014
A. HEK293 cells were transfected with WT OCT4 or OCT4K123R for 48 h and then treated with CoCl2 for various times. Equal amounts of cell lysates were then blotted for OCT4 and α-tubulin. B.
Tao Cheng (131540), Yupo Ma (236944), Yixin Yao (353108), Wei Dai (95957), Wen-Chi Chen (286343), Yongping Jiang (296449), Lou Lu (518137), Yinghua Lu (518136)   +7 more
core   +1 more source

Oct4 to count 2 [PDF]

Cell Research, 2009
openaire   +2 more sources

Characterising differential maturation of stem cell‐derived islets in mice: Graft function and transcriptomic analysis

Diabetic Medicine, EarlyView.
Abstract Aims Stem cell‐derived islets (SC‐islets) offer the potential to revolutionise type 1 diabetes treatment. However, functional maturation in vivo is variable, suggesting that specific, but as‐yet undefined, environmental cues are critical. We aimed to identify pathways associated with SC‐islet in vivo maturation in mice, assess early functional
Rosie Sullivan, Lydia F. Daniels Gatward, Tzu‐Wen Hong, Zekun Lyu, William T. Blackstone Whines, Claire Duff, Ryea Arora, Adya Lonsane, Min Zhao, Victoria Salem, Aileen J. F. King, Peter M. Jones, Shanta J. Persaud   +12 more
wiley   +1 more source

Oct4 Distribution and Level in Mouse Clones: Consequences for Pluripotency

, 2002
OCT4 DISTRIBUTION AND LEVEL IN MOUSE CLONES: CONSEQUENCES FOR PLURIPOTENCY Oct4 Distribution and Level in Mouse Clones: Consequences for Pluripotency (16) (-
Boiani, Michele Sigrid Eckardt Hans Scholer John McLaughlin
core   +1 more source

Single-Cell Dissection of Inflammatory Suppression and Stemness Plasticity Reveals STMN1-Associated Malignant Epithelial Cells in Severe Lung Cancer. [PDF]

Chem Biol Drug Des
Using single‐cell transcriptomics of lung adenocarcinoma samples (from normal lung to advanced lung cancer with malignant serous effusions, ALC‐MSE) integrated with the TCGA‐LUAD cohort, this study systematically characterized the functional evolution of malignant epithelial cells across disease stages.
Chen Y, Chen S, Cheng B, Tang Y, Huang Y, Chen M.   +5 more
europepmc   +2 more sources

Die Rolle von Oct4 während der Entwicklung des Maus Entoderms

, 2016
Oct4 is the major transcription factor responsible activating the pluripotency network. We could however show that Oct4 function is also important for proper formation of hindgut endoderm and correct left-right axis establishment.
Hasenöder, Stefan
core