Results 131 to 140 of about 43,496 (227)

OCT4 learns to count [PDF]

Nature Reviews Molecular Cell Biology, 2009
openaire   +1 more source

The Therapeutic Potential of Stem Cell Therapy for Doxorubicin‐Induced Cardiotoxicity: A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent whose clinical utility is significantly constrained by severe side effects, most notably DOX‐induced cardiotoxicity (DIC). Pathophysiological mechanisms of DIC include oxidative stress, mitochondrial dysfunction, programmed cell death, and inflammation ...
Ali Mirzaei, Pouria Rezaei, Reza Golchin Vafa, Saleheh Jahani, Reza Arefnezhad, Hossein Fatemian, Mohammad Hossein Nikoo, Amirhossein Sahebkar, Fatemeh Rezaei‐Tazangi   +8 more
wiley   +1 more source

RHEBL1 expression is activated by the Oct4-Sox2 complex in oral squamous cell carcinoma. [PDF]

Funct Integr Genomics
Qiu F, Chen Y, Li P, Chen Z, Lam AK, Liang Y, Sun X, Jiang Q, Qiao B.   +8 more
europepmc   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

OCT4-driven PER1 activation promotes odontogenic differentiation in senescent SCAP spheres. [PDF]

Int J Oral Sci
Li C, Zhang Z, Yang Z, Liu T, He X, Li B, Wang W.   +6 more
europepmc   +1 more source

A new role for Oct4 [PDF]

Nature Reports Stem Cells, 2009
openaire   +1 more source

The Toll‐Like Receptor Signalling Pathway Is Altered in iPSC‐Derived Cortical Networks From People With Bipolar Disorder

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Induced pluripotent stem cell (iPSC)‐derived brain cells are widely utilised as in vitro models for several neuropsychiatric disorders, as they retain the donor's genetic profile, offering a unique opportunity to study living human brain cells and perform controlled experimental manipulations.
Bruna Panizzutti, Chiara Cristina Bortolasci, Megan Ellis, Briana Spolding, Courtney Swinton, Trang T. T. Truong, Cassie Field, Zoe Shih‐Jung Liu, Damián Hernández, Greg Roebuck, Ajeet B. Singh, Bruno Agustini, Robson Zazula, Ana C. Andreazza, Dana El Soufi El Sabbagh, Hyunjin Jeong, Olivia M. Dean, Jee Hyun Kim, Michael Berk, Ken Walder   +19 more
wiley   +1 more source

A Mechanistic Model of the HIF-1/HIF-2 Switch Regulating Hypoxia-Induced Cancer Stemness. [PDF]

Int J Mol Sci
Zhan H, Wang P, Liu F.
europepmc   +1 more source

Establishment of Human Formative Pluripotent Stem Cell‐Like Cells Exhibiting Amniotic Differentiation Potentials

Cell Proliferation, Volume 59, Issue 8, August 2026.
The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang, Qizhi Wang, Yu Wu, Chen Gu, Mingfei Li, Yong Fan, Xiangjin Kang, Lei Li, Zheng Gao, Mingyan Hei, Jianqiao Liu, Lei Li   +11 more
wiley   +1 more source

PRX5 as a critical driver of colorectal cancer stemness and tumorigenicity. [PDF]

Redox Rep
Lee SW, Park SJ, Lee GE, Jung SM, Lee J, Kwon S, Yeom E, Lee DS, Choi EH.   +8 more
europepmc   +1 more source