Results 161 to 170 of about 54,485 (283)

Anti-inflammatory Effects of Oct4/Sox2-overexpressing Human Adipose Tissue-derived Mesenchymal Stem Cells

, 2017
Background/Aim: The transcription factors Oct4 and Sox2 enhance the proliferation and pluripotency of human adipose tissue-derived mesenchymal stem cells (hAT-MSCs); however, the anti-inflammatory effects of Oct4-and Sox2-overexpressing hAT-MSCs (Oct4 ...
SEI-MYOUNG HAN, Ryu, Min-Ok, Song, Woo-Jin, QIANG LI, Youn, Hwa-Young, HWA-YOUNG YOUN, SANG-CHUL PARK,, MIN-OK RYU, Li, Qiang, 윤화영, Park, Sang-Chul, Han, Sei-Myoung, WOO-JIN SONG,   +12 more
core   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Oct4 kinetics in irradiated and nonirradiated regions.

, 2013
A, FRAP was used to study Oct4 kinetics in nonirradiated mESCs and GFP-Oct4 recovery in UV-damaged chromatin. B, GFP-Oct4 recovery after photobleaching was studied in control nonirradiated cell nuclei (blue line) and compared with that in TSA-treated ...
Soňa Legartová (338286), Lenka Stixová (338283), Gabriela Šustáčková (338282), Veronika Foltánková (338288), Stanislav Kozubek (338284), Eva Bártová (338281)   +5 more
core   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Structural arrangements of the Oct4 and Sox2 proteins.

, 2016
(A) The Oct4/Sox20bp complex with 0 base pairs separating their DNA-binding sites, in which the POUS α1 helix and the HMG α3 helix are involved in protein-protein interactions. (B) Oct4/Sox23bp complex with 3 base pairs separating their DNA-binding sites,
Masaud Shah (390960), Muhammad Ayaz Anwar (780436), Dhanusha Yesudhas (847724), Sangdun Choi (122038), Suresh Panneerselvam (5666563), Prasannavenkatesh Durai (122034)   +5 more
core   +1 more source

OCT4 and MENA immunoprofiling in salivary mucoepidermoid carcinoma

Diagnostic Pathology
Abstract Background Mucoepidermoid carcinoma (MEC) emblematizes the predominant malignant salivary gland neoplasm, characterized by its heterogeneous morphological features and diverse clinical representations. The expression patterns and prognostic significance of Octamer transcription factor 4 (OCT4) and Mammalian ...
Omnia Samir, Doaa A. Farag, Khadiga M. Ali, Lawahez El. M. Ismail   +3 more
openaire   +3 more sources

Pattern‐based interpretation of SOX2 expression in ovarian teratomas: avoiding diagnostic pitfalls in the distinction between immature and mature neuroectodermal elements

Histopathology, EarlyView.
Ovarian immature teratoma grading may be confounded by mature neuroectodermal mimics. SOX2 labelled immature neuroepithelium but also mature ependymal and glial tissue, while SALL4 was negative in mature mimics and variably expressed in immature neuroepithelium.
Agnese Orsatti, Caterina Ravaioli, Marco Grillini, Eugenia Franchini, João Lobo, Andres M. Acosta, Veronica Mollica, Claudio Zamagni, Pierandrea De Iaco, Anna Myriam Perrone, Michelangelo Fiorentino, Giovanni Tallini, W. Glenn McCluggage, Costantino Ricci, Antonio De Leo   +14 more
wiley   +1 more source

Air‐Abrasion With Aluminum Oxide Particles in Non‐Carious Cervical Lesions: Impact on Sclerotic Superficial Layer, Surface Topography, and Restorative Adhesive Performance

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To evaluate the effect of airborne‐particle abrasion (APA) with aluminum oxide on superficial dentin sclerosis, surface topography, and bonding performance of a universal adhesive in natural non‐carious cervical lesions (NCCLs), using dentin classification by the North Carolina Index (NCI) and Optical Coherence Tomography Index (OCT).
Nathalie Murielly Rolim de Abreu, Romina Ñaupari‐Villasante, Pedro Henrique de Aguiar Moreira, Alessandro D. Loguercio, Frederico Barbosa de Sousa   +4 more
wiley   +1 more source

Pathway enrichment and confirmation of a subset of differentially expressed genes following Oct4 depletion.

, 2013
Litters depicted in ‘A,B’ were induced with tamoxifen ∼E7.0 (Table S1AE). The FDR for reported enrichments in ‘A,B’ is
Andras Nagy (58911), Paria Mohseni (484734), Alexey Tomilin (197899), Larysa Pevny (484737), Charles Yoon (484735), Anthony Lin (484736), Irina Brokhman (484733), Peter W. Zandstra (79978), Kento Onishi (261459), Brian DeVeale (174713), Tomas Babak (6744), Derek van der Kooy (7574)   +11 more
core   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source