Results 1 to 10 of about 147,099 (176)

The Lung-Specific CC10 Gene Is Regulated by Transcription Factors from the AP-1, Octamer, and Hepatocyte Nuclear Factor 3 Families [PDF]

Molecular and Cellular Biology, 1993
We have shown that a large fragment (-2339 to +57) from the rat CC10 gene directed lung-specific expression of a reporter construct in transgenic animals. Upon transfection, a smaller fragment (-165 to +57) supported reporter gene expression exclusively in the Clara cell-like NCI-H441 cell line, suggesting that a Clara cell-specific transcriptional ...
P L, Sawaya, B R, Stripp, J A, Whitsett, D S, Luse   +3 more
openaire   +3 more sources

Orbital metastasis of choriocarcinoma from a testicular malignant germ cell tumor: A late unfavorable prognostic sign

Indian Journal of Ophthalmology. Case Reports, 2023
A 43-year-old man presented with a painful left proptosis 6 years after he had had orchiectomy for a mixed germ cell tumor. He also previously developed pulmonary and brain metastases, which were treated with chemotherapy and radiotherapy.
Hayyam Kiratli, Abdullah Ağın, İrem Koç, Orkun Akman, Figen Söylemezoğlu   +4 more
doaj   +2 more sources

Seminoma and dysgerminoma: evidence for alignment of clinical trials and de-escalation of systemic chemotherapy

Frontiers in Oncology, 2023
Malignant germ cell tumours are a group of rare cancers whose incidence peaks in late adolescence and early adulthood. Dysgerminomas of the ovary and seminomas of the testis are analogous diseases, but seminomas have a 10-fold higher incidence.
Georgina E. Wood, Christopher P. Bunting, Mesel Veli, Rupali Arora, Daniel M. Berney, Constantine Alifrangis, Nicola D. MacDonald, Rowan E. Miller, Rowan E. Miller, Jonathan Shamash, Sara Stoneham, Michelle Lockley, Michelle Lockley   +12 more
doaj   +2 more sources

Clinicopathological Significance of Cancer Stem Cell Markers (OCT-3/4 and SOX-2) in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma

Biomedicines, 2023
Oral submucous fibrosis (OSMF) is highly prevalent in South East Asia with higher rates of malignant transformation in Indian subcontinent. Numerous biomarkers are now being studied to predict disease prognosis and detect malignant alterations at an ...
Divyambika Catakapatri Venugopal, Cynthia Leslie Caleb, Nandhini Priyadarshini Kirupakaran, Vidyarani Shyamsundar, Soundharya Ravindran, Madhavan Yasasve, Arvind Krishnamurthy, Thamizhchelvan Harikrishnan, Sathasivasubramanian Sankarapandian, Vijayalakshmi Ramshankar   +9 more
doaj   +2 more sources

lncRNA KLF3-AS1 Suppresses Cell Migration and Invasion in ESCC by Impairing miR-185-5p-Targeted KLF3 Inhibition

Molecular Therapy: Nucleic Acids, 2020
Esophageal squamous cell carcinoma (ESCC) is a common cancer occurring in males and females worldwide. Accumulating evidence continues to highlight the crucial roles of long non-coding RNAs (lncRNAs) in the process of tumorigenesis.
Jun-Qi Liu, Ming Deng, Nan-Nan Xue, Ting-Xuan Li, Yue-Xin Guo, Liang Gao, Di Zhao, Rui-Tai Fan   +7 more
doaj   +2 more sources

RNA analysis based on a small number of manually isolated fixed cells (RNA-snMIFxC) to profile stem cells from human deciduous tooth-derived dental pulp cells

Biological Procedures Online, 2021
Background Expression of stemness factors, such as octamer-binding transcription factor 3/4 (OCT3/4), sex determining region Y-box 2 (SOX2), and alkaline phosphatase (ALP) in human deciduous tooth-derived dental pulp cells (HDDPCs) can be assessed ...
Emi Inada, Issei Saitoh, Naoko Kubota, Yoko Iwase, Yuki Kiyokawa, Hirofumi Noguchi, Youichi Yamasaki, Masahiro Sato   +7 more
doaj   +3 more sources

Diagnostic Value of SALL4 and OCT3/4 in Pediatric Testicular Tumors

Diagnostics
Testicular tumors (TTs) are rare in children, posing diagnostic and therapeutic challenges. This retrospective study evaluates the diagnostic and prognostic utility of SALL4 and OCT3/4 in pediatric TTs.
Ovidiu Bîcă, Carmen Iulia Ciongradi, Marius Ivănuță, Victor Ianole, Ioan Sârbu, Elena Cojocaru, Delia Elena Bîcă, Ludmila Lozneanu   +7 more
doaj   +2 more sources

Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors

Stem Cell Research & Therapy, 2020
Background Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate characteristics of CSCs ...
Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue   +15 more
doaj   +3 more sources

Assessment of the association of OCT3/4 with GLUT1 and CD105 in oral squamous cell carcinoma using dual immunohistochemistry

BMC Oral Health, 2022
Background Oral squamous cell carcinoma (OSCC) is the most common cancer affecting the oral and maxillofacial region. This study aimed to investigate the role of cancer stem cells (CSCs) in angiogenesis and hypoxic response in OSCC.
Samira Derakhshan, Nazanin Mahdavi, Neda Kardouni Khoozestani, Bita Nasr Esfahani, Foroozan Heidarian, Sedigheh Rahrotaban, Ali Abdolrahmani   +6 more
doaj   +2 more sources

Choriocarcinoma in a 73-year-old woman: a case report and review of the literature

Journal of Medical Case Reports, 2010
Introduction Choriocarcinoma is a highly malignant tumor of trophoblastic origin. Most cases present within one year of the antecedent pregnancy (molar or non-molar).
Said Rabih, Gupta Shilpi, Desai Nisarg R, Desai Priyal, Dai Qun   +4 more
doaj   +2 more sources