Results 31 to 40 of about 147,099 (176)

Heterogeneity of B cell lymphopoiesis in patients with premalignant and active myeloma

JCI Insight, 2023
To better characterize the heterogeneity of multiple myeloma (MM), we profiled plasma cells (PCs) and their B cell lymphopoiesis in the BM samples from patients with monoclonal gammopathy of undetermined significance, smoldering MM, and active MM by mass
Jana Jakubikova, Danka Cholujova, Gabor Beke, Teru Hideshima, Lubos Klucar, Merav Leiba, Krzysztof Jamroziak, Paul G. Richardson, Efstathios Kastritis, David M. Dorfman, Kenneth C. Anderson   +10 more
doaj   +1 more source

Comparison of immunohistochemical profiles of ovarian germ cells in dysgerminomas of a captive maned wolf and domestic dogs

Journal of Veterinary Diagnostic Investigation, 2021
We characterized the immunohistochemical expression profiles of dysgerminomas from a 16-y-old maned wolf and 13 domestic dogs using the following biomarkers: Sal-like protein 4 (SALL4), octamer-binding transcription factor 3/4 (OCT3/4), placental ...
R. B. Rosa, M. Bianchi, P. R. Ribeiro, F. Argenta, Andréia Vielmo, F. B. de Sousa, M. M. Piva, C. B. Pohl, Y. Daoualibi, F. G. Cony, C. Brunner, Raquel von Hohendorff, L. Sonne   +12 more
semanticscholar   +1 more source

Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis

OncoTarget, 2016
Cancer stem cells (CSCs) are a sub-population of tumor cells playing essential roles in initiation, differentiation, recurrence, metastasis and development of drug resistance of various cancers, including bladder cancer.
Qiuli Liu, Wenqiang Yuan, D. Tong, Gaolei Liu, W. Lan, Dianzheng Zhang, Hualiang Xiao, Yao Zhang, Zaoming Huang, Jun-jie Yang, Jun Zhang, Jun Jiang   +11 more
semanticscholar   +1 more source

RETRACTED: The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models

Cancers, 2019
Therapies against glioblastoma (GBM) show a high percentage of failure associated with the survival of glioma stem cells (GSCs) that repopulate treated tumours.
G. Gravina, A. Mancini, A. Colapietro, S. Delle Monache, R. Sferra, F. Vitale, L. Cristiano, S. Martellucci, F. Marampon, V. Mattei, Filip Beirinckx, P. Pujuguet, L. Sanière, G. Lorenzon, E. M. van der Aar, C. Festuccia   +15 more
semanticscholar   +1 more source

Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway

International Journal of Molecular Sciences, 2018
The cardiac glycosides oleandrin and odoroside A, polyphenolic monomer compounds extracted from Nerium oleander, have been found to have antitumor effects on various tumors at low doses.
Y. Ko, Trojan Rugira, Hana Jin, S. Park, H. J. Kim   +4 more
semanticscholar   +1 more source

Thalamic germinoma: A case report

The Indian journal of child health, 2021
Germinomas involving non-midline structures such as thalamus and basal ganglia are relatively uncommon contributing up to 5–10% of all intracranial germ cell tumors.
Nithisha Thatikonda, A. Pathak
semanticscholar   +1 more source

Runx3 Acts as Homodimeric Chromatin Binding Factor Regulating Heterochromatin-Mediated Cancerous Phenotype

bioRxiv
The recent paradoxical dual citizenships of Runt-related transcription factor 3 (Runx3) in tumorigenesis remains poorly characterized. Here, we report the oncogenic capacity of Runx3 as chromatin modulator in metastatic gastric cancer model. Runx3 exists
Salma Awad Merghani, Isabelle Bonne, Aik Yong Sim, Gehan El-Enain   +3 more
semanticscholar   +1 more source

Liver-specific factor binding to the liver promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.

Journal of Biological Chemistry, 1993
The liver-type and muscle-type isozymes of 6-phosphofructo-2-kinase/fructose- 2,6-bisphosphatase are encoded by the same gene from different promoters.
F. Lemaigre, S. Durviaux, G. Rousseau
semanticscholar   +1 more source

Synthetic and immunological studies on the OCT4 immunodominant motif antigen-based anti-cancer vaccine

Cancer Biology & Medicine, 2020
Objective: Cancer stem cell is one of the important causes of tumorigenesis as well as a drug target in the treatment of malignant tumor. However, at present, there is no immune vaccine targeting these cells. Octamer-binding transcription factor 4 (OCT4),
Tingting Chen, Kan Liu, Jiangyao Xu, Tianying Zhan, Maixian Liu, Li Li, Zhiwen Yang, Shuping Yuan, Wenyi Zou, Guimiao Lin, Dennis A. Carson, Christina C. N. Wu, Xiaomei Wang   +12 more
doaj   +1 more source

The core four - A panel of immunohistochemistry markers to diagnose and subtype testicular germ cell tumors

Urology Annals, 2022
Context: Immunohistochemistry (IHC) to differentiate germ cell tumors. Aims: The aim of the study is to differentiate seminomatous and nonseminomatous germ cell tumors (GCTs) with morphological overlap using a minimal and affordable panel of IHC markers.
V N Ranjitha, Rashmi Khemani, B Vishal Rao, Daphne Fonseca, S Sudha Murthy, Ashwin Giridhar, Y Jayakarthik, Rakesh Sharma, K V V. N. Raju, T Subramanyeshwar Rao, Challa Sundaram   +10 more
doaj   +1 more source