Structural Mechanism behind Distinct Efficiency of Oct4/Sox2 Proteins in Differentially Spaced DNA Complexes. [PDF]
PLoS ONE, 2016 The octamer-binding transcription factor 4 (Oct4) and sex-determining region Y (SRY)-box 2 (Sox2) proteins induce various transcriptional regulators to maintain cellular pluripotency.
Dhanusha Yesudhas +5 more
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Association of NRF2 with HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic condition
Redox Biology, 2023 The acquisition of the cancer stem cell (CSC) properties is often mediated by the surrounding microenvironment, and tumor hypoxia is considered an important factor for CSC phenotype development.
Steffanus Pranoto Hallis +3 more
doaj +1 more source
Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice
Frontiers in Endocrinology, 2020 As a member of the POU (Pit-Oct-Unc) transcription factor family, OCT4 (Octamer-binding transcription factor 4) is associated with the cellular proliferative. However, the roles of OCT4 in regulating the transition from preantral follicle to early antral
Dai Heng +8 more
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Oncology Letters, 2015 Osteosarcoma (OS) is an aggressive primary bone cancer that usually affects children and young adolescents. Previous studies have demonstrated the implications of a small sub-population of cancer stem cells on treatment failure and tumor recurrence.
Lan-Mei Liu +5 more
semanticscholar +1 more source
Effect of low oxygen tension on transcriptional factor OCT4 and SOX2 expression in New Zealand rabbit bone marrow-derived mesenchymal stem cells [PDF]
Veterinary World, 2020 Background and Aim: Octamer-binding transcription factor 4 (OCT4) and sex-determining region Y-box 2 (SOX2) are transcription factors whose functions are essential to maintain the pluripotency of embryonic stem cells.
Erma Safitri
doaj +1 more source
Reproduction, Fertility and Development, 2019 In order to help elucidate the process of epiblast and trophoblast cell differentiation in bovine embryos invitro, we attempted to develop a suitable culture medium to allow extended embryo culture.
M. Hosoe +9 more
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Cell & Bioscience, 2021 Background Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases.
Xianglin Mei +8 more
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Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2 [PDF]
Asian-Australasian Journal of Animal Sciences, 2020 Objective Human mesenchymal stromal cells (MSCs) exhibit variable differentiation potential and can be divided accordingly into distinct subpopulations whose ratios vary with donor age. However, it is unknown whether the same is true in pigs.
Ryounghoon Jeon +3 more
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Focused Ultrasound-Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri-Focally Localized Glioblastoma Cells. [PDF]
Int J CancerGlioblastoma (GBM) is highly aggressive and therapy‐resistant, warranting exploration of novel treatment strategies, among them mechanical high‐intensity focused ultrasound (mFUS), which holds significant promise for tumor ablation. The present study examined mFUS‐induced changes specifically in carbohydrate metabolism, which affects vulnerability to ...
Bayler F +10 more
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Cellular Functions of OCT-3/4 Regulated by Ubiquitination in Proliferating Cells
Cancers, 2020 Octamer-binding transcription factor 3/4 (OCT-3/4), which is involved in the tumorigenesis of somatic cancers, has diverse functions during cancer development.
K. Baek, Jihye Choi, C. Pei
semanticscholar +1 more source