Results 41 to 50 of about 147,099 (176)

High‐mobility‐group protein 2 regulated by microRNA‐127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells

Hepatology Communications, 2017
High‐mobility‐group protein 2 (HMGB2) expression is up‐regulated in human liver cancer; however, little is known about its regulatory function. Here, we establish HMGB2 as a new modulator of the pluripotency of mouse embryonic stem cells.
Yulan Zhao, Zhihong Yang, Jianguo Wu, Raymond Wu, Santosh K. Keshipeddy, Dennis Wright, Li Wang   +6 more
doaj   +1 more source

Surgical-derived oral adipose tissue provides early stage adult stem cells

Journal of Dental Sciences, 2014
Background/purpose: Stem cells (SCs) are characterized by the ability to undergo self-renewal and differentiation into multi-lineage cell types. The low risk to donors, the ease of harvest, and the abundance in the human body of adipose-derived SCs make ...
Juin-Hong Cherng, Shu-Jen Chang, Tong-Jing Fang, Meng-Lun Liu, Chung-Hsing Li, Shih-Fang Yang, Jiang-Chuan Liu, Nien-Hsien Liou, Ming-Lun Hsu   +8 more
doaj   +1 more source

Role of Cancer Stem Cell, Apoptotic Factor, DNA Repair, and Telomerase Toward Radiation Therapy Response in Stage IIIB Cervical Cancer

Oman Medical Journal, 2019
Objectives: Cancer stem cells are involved in radioresistant cancers. Transcription factors Sry-related HMG box (SOX2) and octamer binding transcription factor 4 (OCT4) can confer pluripotent cell characteristics and self-renewal ability and are involved
Lisnawati Rachmadi, Nurjati Chairani Siregar, Mpu Kanoko, Andrijono Andrijono, Saptawati Bardosono, Dwi Anita Suryandari, Sri Mutya Sekarutami, Bethy Suryawathy Hernowo   +7 more
doaj   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Fbxw7 and Skp2 Regulate Stem Cell Switch between Quiescence and Mitotic Division in Lung Adenocarcinoma

BioMed Research International, 2019
Background/Aims The molecular mechanism of dormancy initiation of cancer stem cells (CSCs) is not clear. This study was to explore the molecular mechanism by which CSCs switch from mitotic division to quiescence.
Wenzhu Zhang, Zihan Ren, Lanling Jia, Xin Li, X. Jia, Yuchen Han   +5 more
semanticscholar   +1 more source

Bovine tongue epithelium-derived cells: A new source of bovine mesenchymal stem cells

Bioscience Reports, 2020
Mesenchymal stem cells (MSCs) possess the ability to differentiate into multiple cell lineages, and thus, confer great potential for use in regenerative medicine and biotechnology.
Jienny Lee, J. Byeon, N. Gu, Siu Lee, Se-A Lee, Da-Un Jeong, I. Ouh, I. Cho, Jae-Young Song, Yoon-Hee Lee, B. Hyun   +10 more
semanticscholar   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Multi-Omics Analysis Reveals Nono–Kcnq2 Regulation of Neuronal Excitability in Chronic Constriction Injury-Induced Neuropathic Pain

Research
Neuropathic pain, resulting from somatosensory nervous system damage or disease, is a debilitating condition marked by spontaneous pain, hypersensitivity, and sensory abnormalities.
Peng Chen, Jing Wu, Shaoshuai Tang, Qian Gong, Chen Wang, Wenjing Wang, Yuanhua Wu, Ting Tang, Ruixi Luo, Zhibing Wu, Zhaoyu Qin, Long Wang   +11 more
doaj   +1 more source

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, EarlyView.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source