Results 71 to 80 of about 54,485 (283)
Stem Cell Reports, 2017 Summary: The POU transcription factor OCT4 is critical for maintaining the undifferentiated state of embryonic stem cells (ESCs) and generating induced pluripotent stem cells (iPSCs), but its precise mechanisms of action remain poorly understood.
Ki Beom Bae +9 more
doaj +1 more source
Analysis of the Oct4 and Sox2 expression in Oct4/Sox2-ATMSCs.
, 2015 (A) RT-PCR analysis revealed that the mRNA expression of Oct4 and Sox2 in Oct4/Sox2-ATMSCs were significantly higher than that in RFP-ATMSCs at 24 h post-transfection.
Hwa-Young Youn (713961) +7 more
core +1 more source
Bidirectional talk between AhR and Oct4
Oncotarget, 2015 The aryl hydrocarbon receptor (AhR) is a member of the family of basic helix-loop-helix transcription factors that is widely expressed in most differentiated mammalian cells and implicated in a variety of cellular processes, such as cell cycle progression, cell migration, carcinogenesis and immune functions. Upon the binding of its synthetic or natural
Bo, Kang, Ying-Jie, Wang
openaire +2 more sources
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Cells, 2021 The embryonic stem cell marker Oct4 is expressed in several human cancers and is positively correlated with a poor outcome in cancer patients. However, its physiological role in cancer progression remains poorly understood. Tumor cells block apoptosis to
Yu-Chu Su +6 more
doaj +1 more source
Advanced Science, EarlyView.Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen +7 more
wiley +1 more source
Molecular Cancer, 2017 Background Oct4, a key stemness transcription factor, is overexpressed in lung cancer. Here, we reveal a novel transcription regulation of long non-coding RNAs (lncRNAs) by Oct4. LncRNAs have emerged as important players in cancer progression.
Jayu Jen +5 more
doaj +1 more source
OCT4 partially increased SOX2 transcriptional activation.
, 2019 (a) The mutations of SOX2 and OCT4 binding sites downstream of the SOX2 promoter 3’UTR. (b) The luciferase activity of mutations in SOX2 promoter was detected.
Bin Li (39349) +3 more
core +1 more source
H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass [PDF]
Stem Cells, 2016 Abstract Limited core transcription factors and transcriptional cofactors have been shown to govern embryonic stem cell (ESC) transcriptional circuitry and pluripotency, but the molecular interactions between the core transcription factors and cofactors remains ill defined. Here, we analyzed the protein–protein interactions between Oct4,
Lan, Fang +11 more
openaire +2 more sources
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source