Results 31 to 40 of about 54,485 (283)
The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression
Biochemistry and Biophysics Reports, 2021 TRUE gene silencing is one of the gene suppression technologies. This technology exploits the enzymatic property of the tRNA 3' processing endoribonuclease tRNase ZL, which is that it can cleave a target RNA under the direction of a small guide RNA (sgRNA). We have been working on the development of therapeutic sgRNAs for hematological malignancies. In
Tadasuke Nozaki +7 more
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Phosphorylation regulates human OCT4 [PDF]
Proceedings of the National Academy of Sciences, 2012 The transcription factor OCT4 is fundamental to maintaining pluripotency and self-renewal. To better understand protein-level regulation of OCT4, we applied liquid chromatography–MS to identify 14 localized sites of phosphorylation, 11 of which were previously unknown.
Justin, Brumbaugh +7 more
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Cancer Biology & Medicine, 2020 Objective: Cancer stem cell is one of the important causes of tumorigenesis as well as a drug target in the treatment of malignant tumor. However, at present, there is no immune vaccine targeting these cells. Octamer-binding transcription factor 4 (OCT4),
Tingting Chen +12 more
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Expression of OCT4 isoforms is reduced in primary colorectal cancer
Frontiers in Oncology, 2023 IntroductionColorectal cancer (CRC) is one of the most common types of cancer worldwide. The carcinogenesis of CRC is indeed complex, and there are many different mechanisms and pathways that contribute to the development of malignancy and the ...
Eva Turyova +11 more
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The Regulatory Effect of lncRNA PSORS1C3 on Different Variants of OCT4 in non-Pluripotent Cells [PDF]
Journal of Cell and Molecular Research, 2019 OCT4 is the major regulator of pluripotency in embryonic stem cells and its association with tumorigenesis, cellular stress response, and homeostatic multifactorial diseases have been recently reported.
Fatemeh Mirzadeh azad +2 more
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Recruitment of Oct4 protein to UV-damaged chromatin in embryonic stem cells. [PDF]
, 2011 BACKGROUND: Oct4 is a specific marker of embryonic stem cell (ESC) pluripotency. However, little is known regarding how Oct4 responds to DNA damage. Here, we investigated whether Oct4 recognizes damaged chromatin in mouse ESCs stably expressing GFP-Oct4.
Kozubek, Stanislav +17 more
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Oct4-Transfection한 중간엽줄기세포 유래 핵이식 배반포의 Oct4 발현 분포 및 세포 자멸사의 변화에 관한 연구
Journal of Animal Reproduction and Biotechnology, 2016 There are various factors i.e. donor cell type, culture system as well as technical procedures which influence the pre-implantation embryonic development; however, may attempts have been made and still it is under investigation to improve the cloning ...
Won-Jae Lee +3 more
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OCT4 interprets and enhances nucleosome flexibility
Nucleic Acids Research, 2022 Abstract Pioneer transcription factors are proteins that induce cellular identity transitions by binding to inaccessible regions of DNA in nuclear chromatin. They contribute to chromatin opening and recruit other factors to regulatory DNA elements.
MacCarthy, Caitlin M +10 more
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Radiology and Oncology, 2016 The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung ...
Sodja Eva +5 more
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Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5 [PDF]
Transcription, 2010 Long non-coding RNAs (lncRNAs) have been shown to epigenetically regulate certain genes in human cells. Here we report evidence for the involvement of an antisense lncRNA in the transcriptional regulation of the pluripotency-associated factor Oct4. When an lncRNA antisense to Oct4-pseudogene 5 was suppressed, transcription of Oct4 and Oct4 pseudogenes ...
Peter G, Hawkins, Kevin V, Morris
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