Results 31 to 40 of about 43,496 (227)

NBMA Promotes Spermatogenesis by Mediating Oct4 Pathway [PDF]

ChemistryOpen, 2022
AbstractNon‐obstructive azoospermia is one of the most common causes of male infertility, but there is still no specific treatment drug. Given that the Oct4 (Octamer‐binding transcription factor 4) has an important regulatory effect on spermatogenesis, activating it can effectively promote spermatogenesis, so it is of great value to develop Oct4 ...
Jinfei Yang, Dengfeng Lin, Weiwei Yao, Damin Yun, Liwei Zhou, Sheng Gao, Fei Sun   +6 more
openaire   +3 more sources

Effect of High-mobility Group Box-1 on Expression of Stem Cell Markers OCT4, Sox2 and Nanog in Cervical Carcinoma

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the role of High-mobility group box-1 (HMGB1) protein in regulating the expression of cancer stem cell markers Nanog, OCT4 and Sox2.
WANG Hua, CAI Hongbing, LI Shuwei, LI Wei, GAO Qian   +4 more
doaj   +1 more source

NonO Binds to the CpG Island of oct4 Promoter and Functions as a Transcriptional Activator of oct4 Gene Expression [PDF]

Molecules and Cells, 2013
We investigated the relationship between oct4 gene expression patterns and CpG sites methylation profiles during ES cell differentiation into neurons, and identified relevant binding factor. The oct4 gene expression level gradually declined as ES cell differentiation progressed, and the CpG sites in the oct4 proximal enhancer (PE) and promoter regions ...
Yoojin, Park, Ja-Myong, Lee, Min-Young, Hwang, Gi-hoon, Son, Dongho, Geum   +4 more
openaire   +2 more sources

OCT4 induces EMT and promotes ovarian cancer progression by regulating the PI3K/AKT/mTOR pathway

Frontiers in Oncology, 2022
BackgroundOctamer-binding transcription factor 4 (OCT4) is a key stem cell transcription factor involved in the development of various cancers. The role of OCT4 in ovarian cancer (OC) progression and its molecular mechanism are not fully understood ...
Weiwei Xie, Jun Yu, Yujia Yin, Xiaoqian Zhang, Xiaocui Zheng, Xipeng Wang   +5 more
doaj   +1 more source

Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition. [PDF]

PLoS ONE, 2014
Overexpression of Oct4, an important transcription factor of embryonic stem cells (ESC), has been reported in several cancers. The aim of this study was to determine the emerging role of Oct4 in oral squamous cell carcinoma (OSCC) both in vitro and in ...
Lo-Lin Tsai, Fang-Wei Hu, Shiuan-Shinn Lee, Chuan-Hang Yu, Cheng-Chia Yu, Yu-Chao Chang   +5 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Impacts of Haematococcus pluvialis extract on the expression of the SOX2 and OCT4 genes in the prostate cancer cell line, PC3 [PDF]

Caspian Journal of Environmental Sciences
There is a small population of cells with stem cell properties in cancer tissues that are responsible for the initiation of tumour formation and have the ability to resist apoptosis inducing agents and chemotherapy. SOX2 is a transcription factor in stem
Mahsa Khatami, Fatemeh Moradi, Mahmoudreza Aghamaali, Seyedeh Fatemeh Fallah   +3 more
doaj   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Evidence that transcription factor AP-2γ is not required for Oct4 repression in mouse blastocysts.

PLoS ONE, 2013
In mouse blastocysts segregation of the inner cell mass (ICM) and the trophectoderm (TE) is regulated by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2 expressed in the ICM and TE, respectively. In contrast, in other species
Inchul Choi, Timothy S Carey, Catherine A Wilson, Jason G Knott   +3 more
doaj   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source