Results 31 to 40 of about 68,869 (163)
The Sox2 transcription factor binds RNA [PDF]
Nature Communications, 2020 AbstractCertain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor critical for maintenance of pluripotency and neurogenesis, has been found associated with several lncRNAs, although it is unknown whether these interactions are direct or via other ...
Zachariah E. Holmes +6 more
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Functional characterization of SOX2 as an anticancer target [PDF]
Signal Transduction and Targeted Therapy, 2020 AbstractSOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal, reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a complicated network at the levels of transcription, post-transcription, and post-translation.
Shizhen Zhang, Xiufang Xiong, Yi Sun
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SOX2-Sensing: Insights into the Role of SOX2 in the Generation of Sensory Cell Types in Vertebrates
International Journal of Molecular Sciences, 2023 The SOX2 transcription factor is a key regulator of nervous system development, and its mutation in humans leads to a rare disease characterized by severe eye defects, cognitive defects, hearing defects, abnormalities of the CNS and motor control problems.
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SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond [PDF]
Oncogene, 2019 Research of the past view years expanded our understanding of the various physiological functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis, reprogramming, and cancer. However, while scientific reports featuring novel and exciting aspects of SOX2-driven biology are published in near weekly routine, investigations in the ...
Thorsten Schaefer, Claudia Lengerke
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Decreased Sox2 messenger RNA expression in basal cell carcinoma
Indian Journal of Dermatology, 2020 Background: Sox2, zeb1, and p21 have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma. However, their expression level in basal cell carcinoma (BCC) has not been elucidated.
Reza Ahmadi-Beni +8 more
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SOX2 as a New Regulator of HPV16 Transcription [PDF]
Viruses, 2017 Persistent infections with high-risk human papillomavirus (HPV) constitute the main risk factor for cervical cancer development. HPV16 is the most frequent type associated to squamous cell carcinomas (SCC), followed by HPV18. The long control region (LCR) in the HPV genome contains the replication origin and sequences recognized by cellular ...
Imelda Martínez-Ramírez +10 more
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Craniofacial Development Is Fine-Tuned by Sox2
Genes, 2023 The precise control of neural crest stem cell delamination, migration and differentiation ensures proper craniofacial and head development. Sox2 shapes the ontogeny of the cranial neural crest to ensure precision of the cell flow in the developing head. Here, we review how Sox2 orchestrates signals that control these complex developmental processes.
Nikolaos Panagiotis Mandalos +4 more
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Sox2 in the differentiation of cochlear progenitor cells [PDF]
Scientific Reports, 2016 AbstractHMG domain transcription factor, Sox2, is a critical gene for the development of cochlear hair cells, the receptor cells for hearing, but this has been ascribed to expansion of the progenitors that become hair cells. Here, we show that Sox2 activated Atoh1, a transcription factor important for hair cell differentiation, through an interaction ...
Kempfle, Judith +2 more
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Transcription factor Six2 induces a stem cell‐like phenotype in renal cell carcinoma cells
FEBS Open Bio, 2019 Renal cell carcinoma (RCC) accounts for 2–3% of adult malignant tumors, and the incidence of RCC worldwide has increased by about 2% over the past two decades.
Na Cheng +3 more
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Radiology and Oncology, 2016 The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung ...
Sodja Eva +5 more
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