Results 31 to 40 of about 86,024 (165)

The prognostic value of whole blood SOX2, NANOG and OCT4 mRNA expression in advanced small-cell lung cancer

Radiology and Oncology, 2016
The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung ...
Sodja Eva, Rijavec Matija, Koren Ana, Sadikov Aleksander, Korošec Peter, Cufer Tanja   +5 more
doaj   +1 more source

Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons

Cells, 2020
Ameloblastomas are locally invasive and aggressive odontogenic tumors treated via surgical resection, which results in facial deformity and significant morbidity.
Pierfrancesco Pagella, Javier Catón, Christian T. Meisel, Thimios A. Mitsiadis   +3 more
doaj   +1 more source

Model of Sox2-protein associations.

, 2013
(A) Sall4 associates with Sox2 primarily through a region C-terminal to the HMG domain of Sox2. The region N-terminal of the HMG domain of Sox2 also mediates the association between Sox2 and Sall4; whereas, the HMG domain of Sox2 may weakly interfere ...
Sunil K. Mallanna (173368), Angie Rizzino (29782), Jesse L. Cox (139259), Xu Luo (180879)   +3 more
core   +1 more source

Timosaponin Inhibit Proliferation and Stem Cell Formation of Lung Cancer Through Regulating Hedgehog Signaling-mediated SOX2

Zhongliu Fangzhi Yanjiu, 2020
Objective To explore the effects of Timosaponin (TMS) on lung cancer and cancer stem cell (CSC) and its underlying mechanism. Methods MTS, Hoechst 33342 staining, flow cytometry, cell migration and plate cloning experiments were used to detect the effect
CAO Song, YAN Xiaoyan, MA Jun, JING Wenjiang, ZHANG Shulian, WANG Juanyi, LI Xiang, WU Xiang   +7 more
doaj   +1 more source

Zebrafish optic nerve regeneration involves resident and retinal oligodendrocytes

Neural Regeneration Research
The visual system of teleost fish grows continuously, which is a useful model for studying regeneration of the central nervous system. Glial cells are key for this process, but their contribution is still not well defined. We followed oligodendrocytes in
Cristina Pérez-Montes, Rosalía Hernández-García, Jhoana Paola Jiménez-Cubides, Laura DeOliveira-Mello, Almudena Velasco, Rosario Arévalo, Marina García-Macia, Adrián Santos-Ledo   +7 more
doaj   +1 more source

Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

eLife, 2020
The sox2 expressing (sox2+) progenitors in adult mammalian inner ear lose the capacity to regenerate while progenitors in the zebrafish lateral line are able to proliferate and regenerate damaged HCs throughout lifetime. To mimic the HC damage in mammals,
Zhian Ye, Zhongwu Su, Siyu Xie, Yuye Liu, Yongqiang Wang, Xi Xu, Yiqing Zheng, Meng Zhao, Linjia Jiang   +8 more
doaj   +1 more source

Sox2^INV is a null allele.

, 2013
Histological analysis of 6.5-dpc embryos from Sox2βgeo2/+, Sox2COIN/+, Sox2INV/+ intercrosses. Sox2+/+ (A), Sox2βgeo2/+ (B), Sox2COIN/+ (D), Sox2COIN/COIN (E), Sox2COIN/βgeo2 (F), and Sox2INV/+ (G) are all phenotypically normal. In contrast, Sox2INV/INV (
Anastasia Kotsoni (305456), Marannia Saridaki (305454), Aris N. Economides (305458), Jessica Lea Harper (305455), Eumorphia Remboutsika (175815), Nikolaos Mandalos (305453), Peter Yang (305457)   +6 more
core   +1 more source

Establishment and validation of glioma patient-derived organoid models

Glioma
Background and Aim: Glioma is one of the most prevalent and refractory brain cancers with a high recurrence rate. Current limitations of experimental in vitro models include their inability to remodel the heterogeneity of the parental tumors and their ...
Anqi Wang, Xiangtong Xie, Lu Hao, Xuetao Li, Yulun Huang, Zhimin Wang   +5 more
doaj   +1 more source

Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis

Clocks & Sleep, 2020
Basic helix-loop-helix (BHLH) transcription factors differentiated embryonic chondrocyte gene 1 (DEC1) and gene 2 (DEC2) regulate circadian rhythms, apoptosis, epithelial mesenchymal transition (EMT), invasions and metastases in various kinds of cancer.
Fuyuki Sato, Ujjal K. Bhawal, Nao Sugiyama, Shoko Osaki, Kosuke Oikawa, Yasuteru Muragaki   +5 more
doaj   +1 more source

Effect of SOX2-siRNA on the biological ability of DPSC-SOX2.

, 2015
(A) Analysis of effect of SOX2-siRNA on SOX2 expression in different groups by qPCR (left) and FACS (right). (B) Effect of SOX2-siRNA on the cell proliferation, migration and adhesion ability of DPSCs-SOX2.
Delu Dong (817547), Yaoyu Chen (160290), Xiaobo Liu (296632), Yulai Zhou (460655), Pengfei Liu (136115), Yi Wang (32470), Jinglei Cai (437865)   +6 more
core   +1 more source