Results 51 to 60 of about 68,869 (163)
PLOS ONE, 2015 Tumorigenic potential of induced pluripotent stem cells (iPSCs) infiltrating population of induced neural stem cells (iNSCs) generated from iPSCs may limit their medical applications. To overcome such a difficulty, direct reprogramming of adult somatic cells into iNSCs was proposed.
Marta Winiecka-Klimek +9 more
openaire +5 more sources
SOX2 is required for inner ear neurogenesis [PDF]
Scientific Reports, 2017 AbstractNeurons of the cochleovestibular ganglion (CVG) transmit hearing and balance information to the brain. During development, a select population of early otic progenitors express NEUROG1, delaminate from the otocyst, and coalesce to form the neurons that innervate all inner ear sensory regions.
Aleta R. Steevens +3 more
openaire +3 more sources
Cervical cancer cells with positive Sox2 expression exhibit the properties of cancer stem cells. [PDF]
PLoS ONE, 2014 BACKGROUND: Although Sox2 expression has been found in several types of cancer, it has not yet been used to identify or isolate CSCs in somatic carcinoma.
Xiao-Fang Liu +4 more
doaj +1 more source
Transcriptional Regulation of Nanog by OCT4 and SOX2 [PDF]
Journal of Biological Chemistry, 2005 Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog.
Rodda, D.J. +6 more
openaire +2 more sources
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the role of High-mobility group box-1 (HMGB1) protein in regulating the expression of cancer stem cell markers Nanog, OCT4 and Sox2.
WANG Hua +4 more
doaj +1 more source
Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. [PDF]
PLoS ONE, 2011 We undertook this study to understand how the transcription factor Sox2 contributes to the malignant phenotype of glioblastoma multiforme (GBM), the most aggressive primary brain tumor.
Marta M Alonso +19 more
doaj +1 more source
Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC
Cell Death and Disease, 2022 Lung squamous cell carcinoma (LUSC) is a histological subtype of non-small cell lung cancer with the worse progression. SRY-Box Transcription Factor 2 (SOX2) copy number amplification (CNA) is the oncogenic driver in ~60% of patients diagnosed with LUSC.
Yingkuan Liang +8 more
doaj +1 more source
SOX2 contributes to melanoma cell invasion [PDF]
Laboratory Investigation, 2012 The mechanisms of melanoma invasion are poorly understood despite extensive inquiry. SRY (sex determining region Y)-box 2 (SOX2) is an embryonic stem cell transcription factor that has recently been discovered to be expressed in human melanoma where it is associated with dermal invasion and primary tumor thickness.
Sasha D, Girouard +8 more
openaire +2 more sources
Expression of nestin, cd133 and sox2 in meningiomas [PDF]
Turkish Neurosurgery, 2017 To investigate the expression of cancer stem cell markers in meningiomas.CD133, Nestin and Sox2 expression levels in 35 paraffin-embedded meningioma tissue samples were assessed using immunohistochemistry.In this study, five cases were atypical (WHO Grade II), two were anaplastic (WHO Grade III), and 28 were benign (WHO Grade I).
Zong-Yu, Xiao +4 more
openaire +2 more sources
JCI Insight, 2023 Pathogenic SRY-box transcription factor 2 (SOX2) variants typically cause severe ocular defects within a SOX2 disorder spectrum that includes hypogonadotropic hypogonadism.
Jessica Cassin +18 more
doaj +1 more source