Results 51 to 60 of about 86,024 (165)

Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC

Cell Death and Disease, 2022
Lung squamous cell carcinoma (LUSC) is a histological subtype of non-small cell lung cancer with the worse progression. SRY-Box Transcription Factor 2 (SOX2) copy number amplification (CNA) is the oncogenic driver in ~60% of patients diagnosed with LUSC.
Yingkuan Liang, Nan Wang, Yijian Zhang, Wei Jiang, Chen Fang, Yu Feng, Haitao Ma, Feng Jiang, Gaochao Dong   +8 more
doaj   +1 more source

SATB1 binding to Sox2 is enhanced by Akt signaling.

, 2013
(A) SATB1 associates with Sox2, but not Oct4 or Klf4. (B) Endogenous interaction between SATB1 and Sox2. SATB1 was immuprecipitated from F9 cell lysates, immuprecipitations were subjected to immunblotting with anti-SATB1 and anti-Sox2.
Zheng Xue (266750), Bingyang Shi (419014), Guanghui Yang (191351), Xue Wang (102830), Bo Chen (32294), Yue Huang (285485), Ben Yang (419015), Yuemin Yan (419016), Wenji Dong (419017), Daishu Han (346593)   +9 more
core   +1 more source

The role of SOX2 in Pituitary development [PDF]

, 2014
SOX2 is expressed in the pituitary anlagen, Rathke’s Pouch (RP), from its induction at 9.0dpc. RP progenitors initially expand, later giving rise to all pituitary cell types.
Goldsmith, S
core  

Effect of Sox2 overexpression on endogenous Sox2:Oct-3/4 target gene expression

, 2011
Copyright information:Taken from "Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes"Nucleic Acids Research 2007;35(6):1773-1786.Published online 25 Feb 2007PMCID ...
Michelle Desler (29778), Angie Rizzino (29782), Janel Kopp (29776), Sunil Mallanna (29777), Brian Boer (29775), Phillip J. Wilder (29780), Cory Bernadt (29781), Harini Chakravarthy (29779)   +7 more
core   +1 more source

Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes. [PDF]

, 2010
Master regulators, such as Sox2, Oct4 and Nanog, control complex gene networks necessary for the self-renewal and pluripotency of embryonic stem cells (ESC).
Sunil K Mallanna, Jesse L. Cox, Angie Rizzino, Xu Luo, Sunil K. Mallanna, Jesse L Cox   +5 more
core   +1 more source

Impacts of Haematococcus pluvialis extract on the expression of the SOX2 and OCT4 genes in the prostate cancer cell line, PC3 [PDF]

Caspian Journal of Environmental Sciences
There is a small population of cells with stem cell properties in cancer tissues that are responsible for the initiation of tumour formation and have the ability to resist apoptosis inducing agents and chemotherapy. SOX2 is a transcription factor in stem
Mahsa Khatami, Fatemeh Moradi, Mahmoudreza Aghamaali, Seyedeh Fatemeh Fallah   +3 more
doaj   +1 more source

Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms

JCI Insight, 2023
Pathogenic SRY-box transcription factor 2 (SOX2) variants typically cause severe ocular defects within a SOX2 disorder spectrum that includes hypogonadotropic hypogonadism.
Jessica Cassin, Maria I. Stamou, Kimberly W. Keefe, Kaitlin E. Sung, Celine C. Bojo, Karen J. Tonsfeldt, Rebecca A. Rojas, Vanessa Ferreira Lopes, Lacey Plummer, Kathryn B. Salnikov, David L. Keefe Jr., Metin Ozata, Myron Genel, Neoklis A. Georgopoulos, Janet E. Hall, William F. Crowley Jr., Stephanie B. Seminara, Pamela L. Mellon, Ravikumar Balasubramanian   +18 more
doaj   +1 more source

Analysis of topological properties of SOX2-miRNA-targets in mouse PPIN.

, 2014
(A) Comparison of SOX2-miRNA and SOX2-non-miRNA targets. (B) Comparison of SOX2-miRNA and non-SOX2-non-miRNA targets.
Liangcai Zhang (156659), Jinlian Hua (182220), Shihua Zhang (21549), Guiyou Liu (224712), Lei Yang (102719), Yongshuai Jiang (194259), Rennan Feng (186785), Mingzhi Liao (473967), Leijie Li (623371)   +8 more
core   +1 more source

Interaktionsstudien und funktionelle Analysen des Transkriptionsfaktors SOX2 in Glioblastomzellen [PDF]

, 2013
Glioblastome sind maligne Neoplasien des Gehirns. Vor einiger Zeit wurde eine Überexpression für den Transkriptionsfaktor SOX2 beschrieben. Anhand von knockdown- und Überexpressionsexperimenten konnte die proliferationsstimulierende Wirkung von SOX2 in ...
Rüther, L. (Lars)
core   +1 more source

Funktion des Transkriptionsfaktors SOX2 in Glioblastomen

, 2013
Gliome sind die häufigsten primären Hirntumore des Menschen. Die Hirntumorstammzell-Hypothese postuliert die Existenz einer Subpopulation an Tumor-initiierenden, Stammzell-ähnlichen Zellen als eine Ursache der ausgesprochenen Malignität.
Collet, C. (Catharina)
core   +1 more source