Cervical cancer cells with positive Sox2 expression exhibit the properties of cancer stem cells. [PDF]
PLoS ONE, 2014 BACKGROUND: Although Sox2 expression has been found in several types of cancer, it has not yet been used to identify or isolate CSCs in somatic carcinoma.
Xiao-Fang Liu +4 more
doaj +1 more source
Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. [PDF]
PLoS ONE, 2011 We undertook this study to understand how the transcription factor Sox2 contributes to the malignant phenotype of glioblastoma multiforme (GBM), the most aggressive primary brain tumor.
Marta M Alonso +19 more
doaj +1 more source
Ovarian-dedifferentiated endometrioid adenocarcinoma: A rare case report
Indian Journal of Pathology and MicrobiologyWe reported a case of dedifferentiated ovarian carcinoma in a 51-year-old woman. The microscopic tumor consisted of well-differentiated endometrioid carcinoma and undifferentiated carcinoma.
Cao Beibei +3 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the role of High-mobility group box-1 (HMGB1) protein in regulating the expression of cancer stem cell markers Nanog, OCT4 and Sox2.
WANG Hua +4 more
doaj +1 more source
Expression of nestin, cd133 and sox2 in meningiomas [PDF]
Turkish Neurosurgery, 2017 To investigate the expression of cancer stem cell markers in meningiomas.CD133, Nestin and Sox2 expression levels in 35 paraffin-embedded meningioma tissue samples were assessed using immunohistochemistry.In this study, five cases were atypical (WHO Grade II), two were anaplastic (WHO Grade III), and 28 were benign (WHO Grade I).
Zong-Yu, Xiao +4 more
openaire +2 more sources
METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
Open MedicineWe aimed to explore the regulatory effects of methyltransferase-like 3 (METTL3) on diabetic retinopathy (DR) by regulating the m6A modification of SOX2 mRNA and elucidating the underlying molecular mechanism.
Chen Xiujuan +4 more
doaj +1 more source
Zebrafish optic nerve regeneration involves resident and retinal oligodendrocytes
Neural Regeneration ResearchThe visual system of teleost fish grows continuously, which is a useful model for studying regeneration of the central nervous system. Glial cells are key for this process, but their contribution is still not well defined. We followed oligodendrocytes in
Cristina Pérez-Montes +7 more
doaj +1 more source
Expression of the stem cell markers NANOG and SOX2 in the cervical squamous carcinogenesis
Radiology and OncologyThe aim of the present study was to assess a diagnostic potential of stem cell markers NANOG and SOX2 for classifying cervical squamous intraepithelial lesions (SILs)/cervical intraepithelial neoplasia (CIN).
Koren Miha +4 more
doaj +1 more source
Establishment and validation of glioma patient-derived organoid models
GliomaBackground and Aim: Glioma is one of the most prevalent and refractory brain cancers with a high recurrence rate. Current limitations of experimental in vitro models include their inability to remodel the heterogeneity of the parental tumors and their ...
Anqi Wang +5 more
doaj +1 more source
MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. [PDF]
PLoS ONE, 2011 BACKGROUND: SRY (sex-determining region Y)-box 2 (SOX2) is a crucial transcription factor for the maintenance of embryonic stem cell pluripotency and the determination of cell fate.
Takeshi Otsubo +5 more
doaj +1 more source