Results 71 to 80 of about 68,869 (163)

SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

eLife, 2016
The transcription factor SOX2 is central in establishing and maintaining pluripotency. The processes that modulate SOX2 activity to promote pluripotency are not well understood. Here, we show SOX2 is O-GlcNAc modified in its transactivation domain during
Samuel A Myers, Sailaja Peddada, Nilanjana Chatterjee, Tara Friedrich, Kiichrio Tomoda, Gregor Krings, Sean Thomas, Jason Maynard, Michael Broeker, Matthew Thomson, Katherine Pollard, Shinya Yamanaka, Alma L Burlingame, Barbara Panning   +13 more
doaj   +1 more source

Evidence That SOX2 Overexpression Is Oncogenic in the Lung

PLoS ONE, 2010
SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung.We show that SOX2 is overexpressed in human squamous cell lung tumors and some adenocarcinomas.
Lu, Y, Futtner, C, Rock, JR, Xu, X, Whitworth, W, Hogan, BL, Onaitis, MW   +6 more
openaire   +4 more sources

Immunohistochemical profiling and neuroepithelial heterogeneity in immature ovarian teratomas: a retrospective digital pathology-based study

Open Medicine
Immature ovarian teratomas are rare malignant germ cell tumours with variable neuroepithelial differentiation and limited prognostic markers. Their grading is subjective and challenging, with heterogeneous clinical behaviour and limited therapeutic ...
Tavdgiridze Nino, Svanadze Tamar, Tevdorashvili George, Kepuladze Shota, Burkadze George   +4 more
doaj   +1 more source

The molecular pathogenesis of SOX2 in prostate cancer

Discover Oncology
Abstract SOX2 is one of the members of the SOX transcription factor family, which is believed to be an important transcription factor that plays a role in embryonic development, maintenance of stem cells, cancer progression, and resistance to cancer treatment.
Shixue Liu, Honglian Yu, Zhankui Zhao
openaire   +3 more sources

NF-YA transcriptionally activates the expression of SOX2 in cervical cancer stem cells.

PLoS ONE, 2019
Roles for SOX2 have been extensively studied in several types of cancer, including colorectal cancer, glioblastoma and breast cancer, with particular emphasis placed on the roles of SOX2 in cancer stem cell. Our previous study identified SOX2 as a marker
Wen-Ting Yang, Zong-Xia Zhao, Bin Li, Peng-Sheng Zheng   +3 more
doaj   +1 more source

KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells

Oncologie
Pancreatic cancer stem cells (CSCs) are known culprits of recurrent pancreatic ductal adenocarcinoma (PDAC). The disputable presence of CSCs in continuous cell lines has led to an extensive application of patient-derived CSC culture for experimentation ...
Teh Yuan Han, Jing Rui, Ramasamy Rajesh, Ho Kok Lian, Sagineedu Sreenivasa Rao, Stanslas Johnson   +5 more
doaj   +1 more source

SOX2 [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Targeting AKT as a promising strategy for SOX2-positive, chemoresistant osteosarcoma

Bone Research
Osteosarcoma (OS) is the most prevalent type of primary malignant bone cancer and currently lacks effective targeted treatments. Increasing evidence indicates that SOX2 overexpression is a primary driver of OS.
Yujie Liu, Li Kang, Jing Luo, Minglei Yang, Da Wang, Juelan Ye, Xinghai Yang, Wei Wan, Jiemin Wong, Jianru Xiao   +9 more
doaj   +1 more source

SOX2 Gene [PDF]

, 2020
openaire   +1 more source

Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cells. [PDF]

Endocr Relat Cancer
Kemkem Y, Quinn M, Kövér B, Santambrogio A, Kaufman-Cook J, Sherwin O, Scriba LD, Brempou D, Segoviano MV, Cameron D, Berger I, Ng W, Nonaka D, Theodoropoulou M, Pamporaki C, Carroll PV, Izatt L, Chapple JP, Bornstein SR, Bechmann N, Steenblock C, Oakey RJ, Andoniadou CL.   +22 more
europepmc   +1 more source