Results 91 to 100 of about 86,024 (165)

Long live sox2: sox2 lasts a lifetime.

, 2011
Sox2 is a key transcription factor required for the maintenance of pluripotency in embryonic cells and morphogenesis of several epithelia. In this issue of Cell Stem Cell, Arnold et al.
Cédric Blanpain, Blanpain, Cédric, Grégory Driessens, Driessens, Grégory   +3 more
core   +1 more source

Role of SOX2 mutations in human hippocampal malformations and epilepsy

, 2006
Purpose: Seizures are noted in a significant proportion of cases of de novo, heterozygous, loss-of-function mutations in SOX2, ascertained because of severe bilateral eye malformations.
Williamson, Kathleen A., Fitzpatrick, David R., Sisodiya, Sanjay M., Ragge, Nicola K., Schneider, Adele, Free, Samantha L., Thompson, Pamela J., Stevens, John M., Hever, Ann, Lorenz, Birgit, van Heyningen, Veronica, Cavalleri, Gianpiero L.   +11 more
core   +1 more source

Targeting AKT as a promising strategy for SOX2-positive, chemoresistant osteosarcoma

Bone Research
Osteosarcoma (OS) is the most prevalent type of primary malignant bone cancer and currently lacks effective targeted treatments. Increasing evidence indicates that SOX2 overexpression is a primary driver of OS.
Yujie Liu, Li Kang, Jing Luo, Minglei Yang, Da Wang, Juelan Ye, Xinghai Yang, Wei Wan, Jiemin Wong, Jianru Xiao   +9 more
doaj   +1 more source

Sox2 expression promotes castration resistant prostate cancer tumor formation.

, 2013
A) Ectopic expression of Sox2 in castrate-sensitive LAPC-4 (LV-Sox2, n = 10 mice) cells is sufficient to promote tumor take in castrated male nude hosts compared to control mice (LV-Control, n = 10) (p = 0.019).
Russell Z. Szmulewitz (289228), Alex M. Rosen (289219), Gladell P. Paner (289227), Donald J. Vander Griend (289229), Steven Kregel (289217), Westin Tom (289225), Kyle J. Kiriluk (289218), Kristen B. Otto (289223), Edwin E. Reyes (289221), Yi Cai (233861)   +9 more
core   +1 more source

LIF signaling pathway regulates the heterogeneous Sox2 transcriptional dynamics in mESCs

Scientific Reports
The LIF signaling pathway is crucial for maintaining self-renewal and pluripotency in mESCs through regulation of factors like Sox2, yet its direct impact on Sox2 transcriptional dynamics remains elusive.
Gaochen Jin, Emilia A. Leyes Porello, Jingchao Zhang, J. Andres Vidal, Bomyi Lim   +4 more
doaj   +1 more source

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus

Biology Open
Linda Serra, Anna Nordin, Mattias Jonasson, Carolina Marenco, Guido Rovelli, Annika Diebels, Francesca Gullo, Sergio Ottolenghi, Federico Zambelli, Michèle Studer, Giulio Pavesi, Claudio Cantù, Silvia K. Nicolis, Sara Mercurio   +13 more
doaj   +1 more source

SOX2 Inhibits Cuproptosis to Affect Cisplatin Resistance in Non-Small Cell Lung Cancer by Activating the Wnt/ATP7B Signaling Pathway. [PDF]

Kaohsiung J Med Sci
Chen K, He FM, Huang YH, Fang T, Zheng YP, Cai JF.   +5 more
europepmc   +1 more source

IL-1α Expands SLC2A1highSPP1highIFNlow Myeloid Cells to Drive Immune Escape and Malignant Transformation of Precancers. [PDF]

Cancer Res
Taner H, Gong W, Lanzel EA, Debnath KC, Nör F, Okuyama K, Wu Y, Ursin CA, Islam S, Hu X, He Y, Fitzsimonds ZR, Li Z, Kuczura JM, Rajesh S, Manousidaki A, Feng S, Lee M, Demehri S, Wen H, Sikora AG, Chambers MS, Myers JN, Polverini PJ, Nör JE, Young S, Wang TD, Que J, Hu J, Xie Y, Moon JJ, Lei YL.   +31 more
europepmc   +1 more source

Deep learning uncovers hidden power of low-affinity motifs. [PDF]

Cell Genom
Bower G, Kvon EZ.
europepmc   +1 more source

Dual-mode SOX2 regulation by miR-150 via mRNA suppression and autophagy controls stem cell fate. [PDF]

Signal Transduct Target Ther
Zhen X, Koh H, Lee DS, Huh JW, Hong SH, Kim TD, Lee JH.   +6 more
europepmc   +1 more source