Results 61 to 70 of about 68,869 (163)

MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. [PDF]

PLoS ONE, 2011
BACKGROUND: SRY (sex-determining region Y)-box 2 (SOX2) is a crucial transcription factor for the maintenance of embryonic stem cell pluripotency and the determination of cell fate.
Takeshi Otsubo, Yoshimitsu Akiyama, Yutaka Hashimoto, Shu Shimada, Kentaro Goto, Yasuhito Yuasa   +5 more
doaj   +1 more source

Ovarian-dedifferentiated endometrioid adenocarcinoma: A rare case report

Indian Journal of Pathology and Microbiology
We reported a case of dedifferentiated ovarian carcinoma in a 51-year-old woman. The microscopic tumor consisted of well-differentiated endometrioid carcinoma and undifferentiated carcinoma.
Cao Beibei, Zhen Junhai, Ru Guoqing, Peng Fang   +3 more
doaj   +1 more source

METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2

Open Medicine
We aimed to explore the regulatory effects of methyltransferase-like 3 (METTL3) on diabetic retinopathy (DR) by regulating the m6A modification of SOX2 mRNA and elucidating the underlying molecular mechanism.
Chen Xiujuan, Ling Qipeng, Xu Jie, Ye Yunyao, Dong Lili   +4 more
doaj   +1 more source

Expression of the stem cell markers NANOG and SOX2 in the cervical squamous carcinogenesis

Radiology and Oncology
The aim of the present study was to assess a diagnostic potential of stem cell markers NANOG and SOX2 for classifying cervical squamous intraepithelial lesions (SILs)/cervical intraepithelial neoplasia (CIN).
Koren Miha, Zlajpah Margareta, Poljak Mario, Komlos Kristina Fujs, Flezar Margareta Strojan   +4 more
doaj   +1 more source

Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus

Neural Regeneration Research
Neural stem cells (NSCs) have the potential for self-renewal and multidirectional differentiation, and their transplantation has achieved good efficacy in a variety of diseases.
Baocheng Gao, Haoxiang Wang, Shuang Hu, Kunhong Zhong, Xiaoyin Liu, Ziang Deng, Yuanyou Li, Aiping Tong, Liangxue Zhou   +8 more
doaj   +1 more source

Glioma SOX2 expression decreased after adjuvant therapy

BMC Cancer, 2019
Background SOX2 is regarded as an important marker in stem cell. The change of SOX2 expression after adjuvant therapy in high grade glioma (HGG) remains unknown so far.
Wei Yu, Xiaoqiu Ren, Chunxiu Hu, Yinuo Tan, Yongjie Shui, Zexin Chen, Lili Zhang, Jiaping Peng, Qichun Wei   +8 more
doaj   +1 more source

Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling

Gut and Liver
Background/Aims: Cancer stem cells (CSCs) are believed to drive tumor development and metastasis. Activin and hepatocyte growth factor (HGF) are important cytokines with the ability to induce cancer stemness.
Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Qingling Li, Jin Tong, Jinjun Guo   +6 more
doaj   +1 more source

SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma

Cancer Medicine, 2019
Whether SOX2 and ACTL6A/TP63 interact with the Hippo‐YAP1 pathway in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we reveal that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples.
Yuhang Chai, Qihang Li, Hongying Zhao, Zhiyu Zhang, Xiaodan Yu, Lijuan Pang, Zheng Liu, Jin Zhao, Lianghai Wang, Feng Li   +9 more
doaj   +1 more source

Role of Sox2 in the development of the mouse neocortex

Developmental Biology, 2006
The mammalian neocortex is established from neural stem and progenitor cells that utilize specific transcriptional and environmental factors to create functional neurons and astrocytes. Here, we examined the mechanism of Sox2 action during neocortical neurogenesis and gliogenesis.
Bani-yaghoub, Mahmud, Tremblay, Roger G., Lei, Joy X., Zhang, Dongling, Zurakowski, Bogdan, Sandhu, Jagdeep K., Smith, Brandon, Ribecco-Lutkiewicz, Maria, Kennedy, Jessica, Walker, P. Roy, Sikorska, Marianna   +10 more
openaire   +3 more sources

Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system

Open Medicine
Recent studies have highlighted that one of the main drivers for metastatic formation and resistance to the therapy are circulating tumor cells (CTCs) and cancer stem-like cells (CSCs).
Szostakowska-Rodzoś Małgorzata, Fabisiewicz Anna, Myśliwy Izabella, Jagiełło-Gruszfeld Agnieszka, Konieczna Aleksandra, Grzybowska Ewa A.   +5 more
doaj   +1 more source