Results 61 to 70 of about 69,871 (164)

Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC

Cell Death and Disease, 2022
Lung squamous cell carcinoma (LUSC) is a histological subtype of non-small cell lung cancer with the worse progression. SRY-Box Transcription Factor 2 (SOX2) copy number amplification (CNA) is the oncogenic driver in ~60% of patients diagnosed with LUSC.
Yingkuan Liang, Nan Wang, Yijian Zhang, Wei Jiang, Chen Fang, Yu Feng, Haitao Ma, Feng Jiang, Gaochao Dong   +8 more
doaj   +1 more source

Impacts of Haematococcus pluvialis extract on the expression of the SOX2 and OCT4 genes in the prostate cancer cell line, PC3 [PDF]

Caspian Journal of Environmental Sciences
There is a small population of cells with stem cell properties in cancer tissues that are responsible for the initiation of tumour formation and have the ability to resist apoptosis inducing agents and chemotherapy. SOX2 is a transcription factor in stem
Mahsa Khatami, Fatemeh Moradi, Mahmoudreza Aghamaali, Seyedeh Fatemeh Fallah   +3 more
doaj   +1 more source

Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms

JCI Insight, 2023
Pathogenic SRY-box transcription factor 2 (SOX2) variants typically cause severe ocular defects within a SOX2 disorder spectrum that includes hypogonadotropic hypogonadism.
Jessica Cassin, Maria I. Stamou, Kimberly W. Keefe, Kaitlin E. Sung, Celine C. Bojo, Karen J. Tonsfeldt, Rebecca A. Rojas, Vanessa Ferreira Lopes, Lacey Plummer, Kathryn B. Salnikov, David L. Keefe Jr., Metin Ozata, Myron Genel, Neoklis A. Georgopoulos, Janet E. Hall, William F. Crowley Jr., Stephanie B. Seminara, Pamela L. Mellon, Ravikumar Balasubramanian   +18 more
doaj   +1 more source

Biology of regeneration in earthworms: mechanisms, factors and molecular insights. A review

Romanian Journal of Ecology & Environmental Chemistry
Earthworms are ecosystem engineers that play a vital role in soil structure, nutrient cycling, and ecological balance. Beyond their ecological importance, they exhibit remarkable regenerative potential, making them valuable models for studying cellular ...
AMAR KUMAR, ANIRUDDHA MAHATO, SALMAN HAIDER, DAMODAR HEMBRAM, LAXMI SOREN, CHHOTAN MANDAL, ANIT KUMAR HANSDAH, SHALU PRIYA   +7 more
doaj   +1 more source

Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus

Neural Regeneration Research
Neural stem cells (NSCs) have the potential for self-renewal and multidirectional differentiation, and their transplantation has achieved good efficacy in a variety of diseases.
Baocheng Gao, Haoxiang Wang, Shuang Hu, Kunhong Zhong, Xiaoyin Liu, Ziang Deng, Yuanyou Li, Aiping Tong, Liangxue Zhou   +8 more
doaj   +1 more source

Glioma SOX2 expression decreased after adjuvant therapy

BMC Cancer, 2019
Background SOX2 is regarded as an important marker in stem cell. The change of SOX2 expression after adjuvant therapy in high grade glioma (HGG) remains unknown so far.
Wei Yu, Xiaoqiu Ren, Chunxiu Hu, Yinuo Tan, Yongjie Shui, Zexin Chen, Lili Zhang, Jiaping Peng, Qichun Wei   +8 more
doaj   +1 more source

Role of Sox2 in the development of the mouse neocortex

Developmental Biology, 2006
The mammalian neocortex is established from neural stem and progenitor cells that utilize specific transcriptional and environmental factors to create functional neurons and astrocytes. Here, we examined the mechanism of Sox2 action during neocortical neurogenesis and gliogenesis.
Bani-yaghoub, Mahmud, Tremblay, Roger G., Lei, Joy X., Zhang, Dongling, Zurakowski, Bogdan, Sandhu, Jagdeep K., Smith, Brandon, Ribecco-Lutkiewicz, Maria, Kennedy, Jessica, Walker, P. Roy, Sikorska, Marianna   +10 more
openaire   +3 more sources

Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling

Gut and Liver
Background/Aims: Cancer stem cells (CSCs) are believed to drive tumor development and metastasis. Activin and hepatocyte growth factor (HGF) are important cytokines with the ability to induce cancer stemness.
Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Qingling Li, Jin Tong, Jinjun Guo   +6 more
doaj   +1 more source

Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system

Open Medicine
Recent studies have highlighted that one of the main drivers for metastatic formation and resistance to the therapy are circulating tumor cells (CTCs) and cancer stem-like cells (CSCs).
Szostakowska-Rodzoś Małgorzata, Fabisiewicz Anna, Myśliwy Izabella, Jagiełło-Gruszfeld Agnieszka, Konieczna Aleksandra, Grzybowska Ewa A.   +5 more
doaj   +1 more source

SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma

Cancer Medicine, 2019
Whether SOX2 and ACTL6A/TP63 interact with the Hippo‐YAP1 pathway in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we reveal that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples.
Yuhang Chai, Qihang Li, Hongying Zhao, Zhiyu Zhang, Xiaodan Yu, Lijuan Pang, Zheng Liu, Jin Zhao, Lianghai Wang, Feng Li   +9 more
doaj   +1 more source