Results 41 to 50 of about 69,871 (164)

Timosaponin Inhibit Proliferation and Stem Cell Formation of Lung Cancer Through Regulating Hedgehog Signaling-mediated SOX2

Zhongliu Fangzhi Yanjiu, 2020
Objective To explore the effects of Timosaponin (TMS) on lung cancer and cancer stem cell (CSC) and its underlying mechanism. Methods MTS, Hoechst 33342 staining, flow cytometry, cell migration and plate cloning experiments were used to detect the effect
CAO Song, YAN Xiaoyan, MA Jun, JING Wenjiang, ZHANG Shulian, WANG Juanyi, LI Xiang, WU Xiang   +7 more
doaj   +1 more source

Sox2 dosage: A critical determinant in the functions of Sox2 in both normal and tumor cells

Journal of Cellular Physiology, 2019
AbstractThe stem cell transcription factor Sox2 is widely recognized for its many roles during normal development and cancer. Over the last several years, it has become increasingly evident that Sox2 dosage plays critical roles in both normal and malignant cells.
Ethan P. Metz, Angie Rizzino
openaire   +3 more sources

Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

eLife, 2020
The sox2 expressing (sox2+) progenitors in adult mammalian inner ear lose the capacity to regenerate while progenitors in the zebrafish lateral line are able to proliferate and regenerate damaged HCs throughout lifetime. To mimic the HC damage in mammals,
Zhian Ye, Zhongwu Su, Siyu Xie, Yuye Liu, Yongqiang Wang, Xi Xu, Yiqing Zheng, Meng Zhao, Linjia Jiang   +8 more
doaj   +1 more source

Sox2 Uses Multiple Domains to Associate with Proteins Present in Sox2-Protein Complexes

PLoS ONE, 2010
Master regulators, such as Sox2, Oct4 and Nanog, control complex gene networks necessary for the self-renewal and pluripotency of embryonic stem cells (ESC). These master regulators associate with co-activators and co-repressors to precisely control their gene targets. Recent studies using proteomic analysis have identified a large, diverse group of co-
Jesse L Cox, Sunil K Mallanna, Xu Luo, Angie Rizzino   +3 more
openaire   +4 more sources

Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis

Clocks & Sleep, 2020
Basic helix-loop-helix (BHLH) transcription factors differentiated embryonic chondrocyte gene 1 (DEC1) and gene 2 (DEC2) regulate circadian rhythms, apoptosis, epithelial mesenchymal transition (EMT), invasions and metastases in various kinds of cancer.
Fuyuki Sato, Ujjal K. Bhawal, Nao Sugiyama, Shoko Osaki, Kosuke Oikawa, Yasuteru Muragaki   +5 more
doaj   +1 more source

Sox2: To crest or not to crest?

Seminars in Cell & Developmental Biology, 2017
Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominant role as a guardian of the ...
Nikolaos Panagiotis Mandalos, Eumorphia Remboutsika   +1 more
openaire   +3 more sources

SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence

PLOS ONE, 2015
Tumorigenic potential of induced pluripotent stem cells (iPSCs) infiltrating population of induced neural stem cells (iNSCs) generated from iPSCs may limit their medical applications. To overcome such a difficulty, direct reprogramming of adult somatic cells into iNSCs was proposed.
Marta Winiecka-Klimek, Maciej Smolarz, Maciej P Walczak, Jolanta Zieba, Krystyna Hulas-Bigoszewska, Blazej Kmieciak, Sylwester Piaskowski, Piotr Rieske, Dawid P Grzela, Ewelina Stoczynska-Fidelus   +9 more
openaire   +5 more sources

SOX2 is required for inner ear neurogenesis [PDF]

Scientific Reports, 2017
AbstractNeurons of the cochleovestibular ganglion (CVG) transmit hearing and balance information to the brain. During development, a select population of early otic progenitors express NEUROG1, delaminate from the otocyst, and coalesce to form the neurons that innervate all inner ear sensory regions.
Aleta R. Steevens, Danielle L. Sookiasian, Jenna C. Glatzer, Amy E. Kiernan   +3 more
openaire   +3 more sources

Transcriptional Regulation of Nanog by OCT4 and SOX2 [PDF]

Journal of Biological Chemistry, 2005
Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog.
Rodda, D.J., Chew, J.-L., Lim, L.-H., Loh, Y.-H., Wang, B., Ng, H.-H., Robson, P.   +6 more
openaire   +2 more sources

Transcription factor Six2 induces a stem cell‐like phenotype in renal cell carcinoma cells

FEBS Open Bio, 2019
Renal cell carcinoma (RCC) accounts for 2–3% of adult malignant tumors, and the incidence of RCC worldwide has increased by about 2% over the past two decades.
Na Cheng, Hongjuan Li, Yan Han, Shuzhen Sun   +3 more
doaj   +1 more source