Results 41 to 50 of about 68,869 (163)

Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons

Cells, 2020
Ameloblastomas are locally invasive and aggressive odontogenic tumors treated via surgical resection, which results in facial deformity and significant morbidity.
Pierfrancesco Pagella, Javier Catón, Christian T. Meisel, Thimios A. Mitsiadis   +3 more
doaj   +1 more source

Timosaponin Inhibit Proliferation and Stem Cell Formation of Lung Cancer Through Regulating Hedgehog Signaling-mediated SOX2

Zhongliu Fangzhi Yanjiu, 2020
Objective To explore the effects of Timosaponin (TMS) on lung cancer and cancer stem cell (CSC) and its underlying mechanism. Methods MTS, Hoechst 33342 staining, flow cytometry, cell migration and plate cloning experiments were used to detect the effect
CAO Song, YAN Xiaoyan, MA Jun, JING Wenjiang, ZHANG Shulian, WANG Juanyi, LI Xiang, WU Xiang   +7 more
doaj   +1 more source

Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans [PDF]

Journal of Clinical Investigation, 2006
The transcription factor SOX2 is expressed most notably in the developing CNS and placodes, where it plays critical roles in embryogenesis. Heterozygous de novo mutations in SOX2 have previously been associated with bilateral anophthalmia/microphthalmia, developmental delay, short stature, and male genital tract abnormalities.
Kelberman,D, Rizzoti, K, Avilion, A, Bitner Glindzicz, M, CIANFARANI, STEFANO, Collins, J, Kling Chong, W, Kirk, JMW, Achermann, JC, Ross, R, Carmignac, D, Lovell Badge, R. Robinson I. C. A. F., Dattani M. T.   +13 more
openaire   +5 more sources

Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

eLife, 2020
The sox2 expressing (sox2+) progenitors in adult mammalian inner ear lose the capacity to regenerate while progenitors in the zebrafish lateral line are able to proliferate and regenerate damaged HCs throughout lifetime. To mimic the HC damage in mammals,
Zhian Ye, Zhongwu Su, Siyu Xie, Yuye Liu, Yongqiang Wang, Xi Xu, Yiqing Zheng, Meng Zhao, Linjia Jiang   +8 more
doaj   +1 more source

Sox2 dosage: A critical determinant in the functions of Sox2 in both normal and tumor cells

Journal of Cellular Physiology, 2019
AbstractThe stem cell transcription factor Sox2 is widely recognized for its many roles during normal development and cancer. Over the last several years, it has become increasingly evident that Sox2 dosage plays critical roles in both normal and malignant cells.
Ethan P. Metz, Angie Rizzino
openaire   +3 more sources

Zebrafish optic nerve regeneration involves resident and retinal oligodendrocytes

Neural Regeneration Research
The visual system of teleost fish grows continuously, which is a useful model for studying regeneration of the central nervous system. Glial cells are key for this process, but their contribution is still not well defined. We followed oligodendrocytes in
Cristina Pérez-Montes, Rosalía Hernández-García, Jhoana Paola Jiménez-Cubides, Laura DeOliveira-Mello, Almudena Velasco, Rosario Arévalo, Marina García-Macia, Adrián Santos-Ledo   +7 more
doaj   +1 more source

Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis

Clocks & Sleep, 2020
Basic helix-loop-helix (BHLH) transcription factors differentiated embryonic chondrocyte gene 1 (DEC1) and gene 2 (DEC2) regulate circadian rhythms, apoptosis, epithelial mesenchymal transition (EMT), invasions and metastases in various kinds of cancer.
Fuyuki Sato, Ujjal K. Bhawal, Nao Sugiyama, Shoko Osaki, Kosuke Oikawa, Yasuteru Muragaki   +5 more
doaj   +1 more source

Sox2: To crest or not to crest?

Seminars in Cell & Developmental Biology, 2017
Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominant role as a guardian of the ...
Nikolaos Panagiotis Mandalos, Eumorphia Remboutsika   +1 more
openaire   +3 more sources

Establishment and validation of glioma patient-derived organoid models

Glioma
Background and Aim: Glioma is one of the most prevalent and refractory brain cancers with a high recurrence rate. Current limitations of experimental in vitro models include their inability to remodel the heterogeneity of the parental tumors and their ...
Anqi Wang, Xiangtong Xie, Lu Hao, Xuetao Li, Yulun Huang, Zhimin Wang   +5 more
doaj   +1 more source

Sox2 Uses Multiple Domains to Associate with Proteins Present in Sox2-Protein Complexes

PLoS ONE, 2010
Master regulators, such as Sox2, Oct4 and Nanog, control complex gene networks necessary for the self-renewal and pluripotency of embryonic stem cells (ESC). These master regulators associate with co-activators and co-repressors to precisely control their gene targets. Recent studies using proteomic analysis have identified a large, diverse group of co-
Jesse L Cox, Sunil K Mallanna, Xu Luo, Angie Rizzino   +3 more
openaire   +4 more sources