Results 21 to 30 of about 69,871 (164)
Sox2: Masterminding the Root of Cancer [PDF]
Cancer Cell, 2014 The transcription factor Sox2 is a master regulator that maintains stemness in embryonic stem cells and neural stem cells. Using elegant lineage tracing strategies and genetic reporter mouse models, two studies (one of which is by Vanner and colleagues in this issue of Cancer Cell) now demonstrate that rare Sox2-expressing cells are the founding cancer
Tam, Wai Leong, Ng, Huck Hui
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Di-san junyi daxue xuebao, 2019 Objective To explore the effect of karyopherina 2 (KPNA2) knockdown on osteosarcoma cell proliferation and angiogenesis and the possible molecular mechanism.
GE Qiaofeng +3 more
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Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells [PDF]
Research Ideas and Outcomes, 2021 SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2).
Dao-Yin Dong, Pu-Yu Li
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Neural Development, 2021 Background The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading to spinal cord regeneration ...
Gabriela Edwards-Faret +5 more
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A Role for Sox2 in the Adult Cerebellum
Journal of Stem Cell Research & Therapy, 2018 The cerebellum, a derivative of the hindbrain, plays a crucial role in balance and posture as well as in higher cognitive and locomotive processes. Cerebellar development is initiated during the segmental phase of hindbrain formation. Here, we describe the phenotype, of a single surviving adult conditional mouse mutant mouse, in which Sox2 function is ...
Mandalos, Nikolaos Panagiotis +5 more
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Biology Open, 2020 In the anterior foregut (AFG) of mouse embryos, the transcription factor SOX2 is expressed in the epithelia of the esophagus and proximal branches of respiratory organs comprising the trachea and bronchi, whereas NKX2.1 is expressed only in the epithelia
Machiko Teramoto +7 more
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Uncovering the Role of Sox2 in Oligodendroglia [PDF]
The Journal of Neuroscience, 2018 In the CNS, oligodendrocytes are responsible for the formation of myelin. To build these insulating sheaths surrounding axons, cells of the oligodendrocyte lineage must go through an intricate and temporally matched sequence of proliferation, migration, differentiation, and myelination ...
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Targeting SOX2 as a Therapeutic Strategy in Glioblastoma [PDF]
Frontiers in Oncology, 2016 Glioblastoma is the most common and malignant brain cancer in adults. Current therapy consisting of surgery followed by radiation and temozolomide has a moderate success rate and the tumor reappears. Among the features that a cancer cell must have to survive the therapeutic treatment and reconstitute the tumor is the ability of self-renewal. Therefore,
Garros-Regulez, Laura +13 more
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Radiology and Oncology, 2016 The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung ...
Sodja Eva +5 more
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The Sox2 transcription factor binds RNA [PDF]
Nature Communications, 2020 AbstractCertain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor critical for maintenance of pluripotency and neurogenesis, has been found associated with several lncRNAs, although it is unknown whether these interactions are direct or via other ...
Zachariah E. Holmes +6 more
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