Results 21 to 30 of about 68,869 (163)

Immunohistochemical investigation of SOX2 expression in Iraqi patients with high-grade glioma [PDF]

Romanian Journal of Neurology
Background. Gliomas, particularly high-grade gliomas, are aggressive brain tumors with poor prognosis. Sex-determining region Y-box 2 (SOX2) is a transcription factor responsible for stem cell maintenance and differentiation and has been implicated in ...
Hadeer Hashim Shams Uldeen, Abed Hassan Barraj, Sameer Hameed Hammadi   +2 more
doaj   +1 more source

Karyopherina 2 knockdown inhibits osteosarcoma cell proliferation and angiogenesis in mice by suppressing Sox2 expression

Di-san junyi daxue xuebao, 2019
Objective To explore the effect of karyopherina 2 (KPNA2) knockdown on osteosarcoma cell proliferation and angiogenesis and the possible molecular mechanism.
GE Qiaofeng, ZHANG Long, SUN Xiaojuan, LYU Zhi   +3 more
doaj   +1 more source

The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components

Biology Open, 2020
In the anterior foregut (AFG) of mouse embryos, the transcription factor SOX2 is expressed in the epithelia of the esophagus and proximal branches of respiratory organs comprising the trachea and bronchi, whereas NKX2.1 is expressed only in the epithelia
Machiko Teramoto, Ryo Sugawara, Katsura Minegishi, Masanori Uchikawa, Tatsuya Takemoto, Atsushi Kuroiwa, Yasuo Ishii, Hisato Kondoh   +7 more
doaj   +1 more source

Sox2: Masterminding the Root of Cancer [PDF]

Cancer Cell, 2014
The transcription factor Sox2 is a master regulator that maintains stemness in embryonic stem cells and neural stem cells. Using elegant lineage tracing strategies and genetic reporter mouse models, two studies (one of which is by Vanner and colleagues in this issue of Cancer Cell) now demonstrate that rare Sox2-expressing cells are the founding cancer
Tam, Wai Leong, Ng, Huck Hui
openaire   +2 more sources

Construction of recombinant sox2-encoding plasmids that regulate pluripotency of breast cancer stem cells from indonesian patient [PDF]

Pharmaciana, 2019
A therapy development with recombinant protein is a new and potential innovation to destroy cancer stem cells (CSCs). Various ways of killing CSCs include the provision of polyvalent anti-protein antibodies that code pluripotency.
Hanifah Rahmi, Tiodinar Theresia, Amarila Malik, Septelia Inawati Wanandi   +3 more
doaj   +1 more source

Correlation of CD133 and SOX2 Expression with Regional Lymph Nodes Metastatic Status in Invasive Breast Carcinoma of No Special Type

Indonesian Journal of Cancer, 2021
Background: CD133 overexpression can increase cell proliferation, migration, and epithelialmesenchymal transition that promotes metastasis. CD133 expression is induced by hypoxiainduced factor (HIF) which requires SOX2 binding in the promoter region ...
Sutrisno, Dyah Fauziah, Gondo Mastutik
doaj   +1 more source

SOX2 Represses Hepatitis B Virus Replication by Binding to the Viral EnhII/Cp and Inhibiting the Promoter Activation

Viruses, 2020
Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII). EnhII stimulates Cp activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and ...
Hua Yang, Jiayin Mo, Qi Xiang, Peiyi Zhao, Yunting Song, Ge Yang, Kailang Wu, Yingle Liu, Weiyong Liu, Jianguo Wu   +9 more
doaj   +1 more source

A Role for Sox2 in the Adult Cerebellum

Journal of Stem Cell Research & Therapy, 2018
The cerebellum, a derivative of the hindbrain, plays a crucial role in balance and posture as well as in higher cognitive and locomotive processes. Cerebellar development is initiated during the segmental phase of hindbrain formation. Here, we describe the phenotype, of a single surviving adult conditional mouse mutant mouse, in which Sox2 function is ...
Mandalos, Nikolaos Panagiotis, Karampelas, Ioannis, Saridaki, Marannia, McKay, Ronald D. G., Cohen, Mark L., Remboutsika, Eumorphia   +5 more
openaire   +3 more sources

Targeting SOX2 as a Therapeutic Strategy in Glioblastoma [PDF]

Frontiers in Oncology, 2016
Glioblastoma is the most common and malignant brain cancer in adults. Current therapy consisting of surgery followed by radiation and temozolomide has a moderate success rate and the tumor reappears. Among the features that a cancer cell must have to survive the therapeutic treatment and reconstitute the tumor is the ability of self-renewal. Therefore,
Garros-Regulez, Laura, Garcia, Idoia, Carrasco-Garcia, Estefania, Lantero, Aquilino, Aldaz, Paula, Moreno-Cugnon, Leire, Arrizabalaga, Olatz, Undabeitia, Jose, Torres-Bayona, Sergio, Villanua, Jorge, Ruiz, Irune, Egaña, Larraitz, Sampron, Nicolas, Matheu, Ander   +13 more
openaire   +3 more sources

Uncovering the Role of Sox2 in Oligodendroglia [PDF]

The Journal of Neuroscience, 2018
In the CNS, oligodendrocytes are responsible for the formation of myelin. To build these insulating sheaths surrounding axons, cells of the oligodendrocyte lineage must go through an intricate and temporally matched sequence of proliferation, migration, differentiation, and myelination ...
openaire   +2 more sources