Results 11 to 20 of about 69,871 (164)
Specificity and application of SOX2 antibody
Poultry Science, 2020 Sox2 is known to play an important role in maintaining the totipotency and self-renewal of embryonic stem cells. The purpose of this study was to prepare an anti-chicken Sox2 polyclonal antibody using prokaryotic expression techniques, to evaluate its ...
Longqin Wei +11 more
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Long Live Sox2: Sox2 Lasts a Lifetime [PDF]
Cell Stem Cell, 2011 Sox2 is a key transcription factor required for the maintenance of pluripotency in embryonic cells and morphogenesis of several epithelia. In this issue of Cell Stem Cell, Arnold et al. (2011) demonstrate that Sox2 marks long-lived adult stem cells to ensure homeostasis in a broad range of adult tissues.
Driessens, Grégory, Blanpain, Cédric
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Sox2: A multitasking networker [PDF]
Neurogenesis, 2014 The transcription factor Sox2 is best known as a pluripotency factor in stem and precursor cells and its expression generally correlates with an undifferentiated state. Proposed modes of action include those as classical transcription factor and pre-patterning factor with influence on histone modifications and chromatin structure. Recently, we provided
Reiprich, Simone, Wegner, Michael
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Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo [PDF]
Transgenic Research, 2018 Sox2 is a Sry-box containing family member of related transcription factors sharing homology in their DNA binding domain. Sox2 is important during different stages of development, and previously we showed that Sox2 plays an important role in branching morphogenesis and epithelial cell differentiation in lung development. The transcriptional activity of
Kim Schilders +8 more
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Mutations in SOX2 cause anophthalmia [PDF]
Nature Genetics, 2003 A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia. Subsequent SOX2 mutation analysis identified de novo truncating mutations of SOX2 in 4 of 35 (11%) individuals with anophthalmia. Both eyes were affected in all cases with an identified mutation.
Judy, Fantes +10 more
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Molecular & Cellular Oncology, 2020 The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells.
Maria Bååth +8 more
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Viruses, 2020 Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII). EnhII stimulates Cp activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and ...
Hua Yang +9 more
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Rambam Maimonides Medical Journal, 2021 Objectives: To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human ...
Prasanth Thankappan +5 more
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Biology Open, 2021 The development of three-dimensional cell culture techniques has allowed cancer researchers to study the stemness properties of cancer cells in in vitro culture.
Katherine K. Slemmons +8 more
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Immunohistochemical investigation of SOX2 expression in Iraqi patients with high-grade glioma [PDF]
Romanian Journal of NeurologyBackground. Gliomas, particularly high-grade gliomas, are aggressive brain tumors with poor prognosis. Sex-determining region Y-box 2 (SOX2) is a transcription factor responsible for stem cell maintenance and differentiation and has been implicated in ...
Hadeer Hashim Shams Uldeen +2 more
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