Results 11 to 20 of about 68,869 (163)
Comparative characteristic of lung cancer stem-like cells generated in vitro under different culture conditions [PDF]
The Ukrainian Biochemical Journal, 2021 Cancer stem cells (CSCs) play an important role in resistance to cancer treatment and recurrence developing. The aim of this study was to obtain cell culture of MOR line non-small cell lung cancer cells enriched in CSCs and to investigate its functional ...
O. V. Skachkova +4 more
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BIOSCAFFOLD FROM MOUSE EMBRYONIC FIBROBLAST MAINTAINS THE PLURIPOTENCY OF MOUSE EMBRYONIC STEM CELLS
Journal of Stem Cell Research and Tissue Engineering, 2023 Cell culture using a 3D method provides Various cell culture strategies have been developed using synthetic or biological materials; most existing publications use many reagents. Bioscaffold from mouse embryonic fibroblast (MEF) enhances cell attachment,
Rifqah Mifthahul Jannah +2 more
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Rambam Maimonides Medical Journal, 2021 Objectives: To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human ...
Prasanth Thankappan +5 more
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Biology Open, 2021 The development of three-dimensional cell culture techniques has allowed cancer researchers to study the stemness properties of cancer cells in in vitro culture.
Katherine K. Slemmons +8 more
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Sox2: A multitasking networker [PDF]
Neurogenesis, 2014 The transcription factor Sox2 is best known as a pluripotency factor in stem and precursor cells and its expression generally correlates with an undifferentiated state. Proposed modes of action include those as classical transcription factor and pre-patterning factor with influence on histone modifications and chromatin structure. Recently, we provided
Reiprich, Simone, Wegner, Michael
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Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo [PDF]
Transgenic Research, 2018 Sox2 is a Sry-box containing family member of related transcription factors sharing homology in their DNA binding domain. Sox2 is important during different stages of development, and previously we showed that Sox2 plays an important role in branching morphogenesis and epithelial cell differentiation in lung development. The transcriptional activity of
Kim Schilders +8 more
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Mutations in SOX2 cause anophthalmia [PDF]
Nature Genetics, 2003 A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia. Subsequent SOX2 mutation analysis identified de novo truncating mutations of SOX2 in 4 of 35 (11%) individuals with anophthalmia. Both eyes were affected in all cases with an identified mutation.
Judy, Fantes +10 more
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Neural Development, 2021 Background The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading to spinal cord regeneration ...
Gabriela Edwards-Faret +5 more
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Molecular & Cellular Oncology, 2020 The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells.
Maria Bååth +8 more
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Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells [PDF]
Research Ideas and Outcomes, 2021 SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2).
Dao-Yin Dong, Pu-Yu Li
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