Results 11 to 20 of about 86,024 (165)

Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells [PDF]

Research Ideas and Outcomes, 2021
SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2).
Dao-Yin Dong, Pu-Yu Li
doaj   +5 more sources

SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma

Cancer Medicine, 2019
Whether SOX2 and ACTL6A/TP63 interact with the Hippo‐YAP1 pathway in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we reveal that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples.
Yuhang Chai, Qihang Li, Hongying Zhao, Zhiyu Zhang, Xiaodan Yu, Lijuan Pang, Zheng Liu, Jin Zhao, Lianghai Wang, Feng Li   +9 more
doaj   +2 more sources

SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery

Molecular & Cellular Oncology, 2020
The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells.
Maria Bååth, Sofia Westbom-Fremer, Laura Martin de la Fuente, Anna Ebbesson, Juliette Davis, Susanne Malander, Anna Måsbäck, Päivi Kannisto, Ingrid Hedenfalk   +8 more
doaj   +1 more source

Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer. [PDF]

, 2013
The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells.
Friedrich Bootz, Claudia Lengerke, Abbas Agaimy, Stephan Ihrler, Ropika Menon, Maike Bode, Glen Kristiansen, Menon, Ropika, Kristiansen, Glen, Martin Braun, Göke, Friederike, Kirsten, Robert, Robert Kirsten, Huss, Sebastian, Franzen, Alina, Bode, Maike, Alina Franzen, Friederike Göke, Sebastian Huss, Agaimy, Abbas, Sven Perner, Andreas Schröck, Ihrler, Stephan, Braun, Martin, Perner, Sven, Lengerke, Claudia, Bootz, Friedrich, Schröck, Andreas, Wagner, Patrick, Patrick Wagner, Huss Sebastian, Braun Martin, Franzen Alina, Kirsten Robert, Lengerke Claudia, Göke Friederike, Kristiansen Glen, Schröck Andreas, Wagner Patrick, Ihrler Stephan, Bootz Friedrich, Bode Maike, Perner Sven, Menon Ropika, Agaimy Abbas   +44 more
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Immunohistochemical investigation of SOX2 expression in Iraqi patients with high-grade glioma [PDF]

Romanian Journal of Neurology
Background. Gliomas, particularly high-grade gliomas, are aggressive brain tumors with poor prognosis. Sex-determining region Y-box 2 (SOX2) is a transcription factor responsible for stem cell maintenance and differentiation and has been implicated in ...
Hadeer Hashim Shams Uldeen, Abed Hassan Barraj, Sameer Hameed Hammadi   +2 more
doaj   +1 more source

Sorting live stem cells based on Sox2 mRNA expression. [PDF]

, 2012
PMCID: PMC3507951This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Hans M. Larsson (118208), Frey Peter, Larsson, H.M., Velluto, Diana, Hans M. Larsson, Jeffrey A. Hubbell (118232), Roccio Marta, Velluto Diana, Lee, S.T., Hubbell, Jeffrey A., Jeffrey A. Hubbell, Roccio, Marta, Peter Frey (118226), Lee, ST, Roccio, M, Matthias P Lutolf, Lutolf, MP, Velluto, D., Larsson, Hans M., Matthias P. Lutolf (118222), Lutolf, M.P., Frey, P., Larsson Hans M., Jeffrey A Hubbell, Seung Tae Lee, Lutolf Matthias P., Marta Roccio, Hubbell Jeffrey A., Larsson, HM, Velluto, D, Diana Velluto (118218), Peter Frey, Matthias P. Lutolf, Hubbell, JA, Lutolf, Matthias P., Hubbell, J.A., Lee Seung Tae, Roccio, M., Frey, Peter, Lee, Seung Tae, Marta Roccio (118214), Diana Velluto, Hans M Larsson, Seung Tae Lee (118211), Frey, P, Larsson HM, Frey P, Lutolf MP, Hubbell JA, Velluto D, Roccio M, Lee ST   +51 more
core   +3 more sources

Karyopherina 2 knockdown inhibits osteosarcoma cell proliferation and angiogenesis in mice by suppressing Sox2 expression

Di-san junyi daxue xuebao, 2019
Objective To explore the effect of karyopherina 2 (KPNA2) knockdown on osteosarcoma cell proliferation and angiogenesis and the possible molecular mechanism.
GE Qiaofeng, ZHANG Long, SUN Xiaojuan, LYU Zhi   +3 more
doaj   +1 more source

The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components

Biology Open, 2020
In the anterior foregut (AFG) of mouse embryos, the transcription factor SOX2 is expressed in the epithelia of the esophagus and proximal branches of respiratory organs comprising the trachea and bronchi, whereas NKX2.1 is expressed only in the epithelia
Machiko Teramoto, Ryo Sugawara, Katsura Minegishi, Masanori Uchikawa, Tatsuya Takemoto, Atsushi Kuroiwa, Yasuo Ishii, Hisato Kondoh   +7 more
doaj   +1 more source

Contribution of 3q26-29 gene cluster to glioma invasion [PDF]

, 2015
Diffuse gliomas are the most common and lethal brain tumors. Cell invasion into the surrounding brain tissue is a hallmark feature of glioma. Understanding the mechanism of glioma invasion could lead to the discovery of novel therapeutic strategies to ...
Ramadoss, Archana
core   +1 more source

SOX2-KO decreases HCMV gene transcription.

, 2023
SOX2 knockout (SOX2 -KO) and negative control (NC) cells were generated from U251, LN229, and CCF cells by lentivirus transduction. The cells were infected with HCMV Towne strain at an MOI of 5 and collected at the indicated times for viral gene ...
Fei Hu (191861), Simon Rayner (117650), Yong Qiu (83780), Fang-Cheng Li (3384743), Shuang Cheng (610515), Han Cheng (475615), Le Wen (14587872), Xian-Zhang Wang (11680805), Jin-Yan Sun (11930542), Jian Chen (15340), William J. Britt (15295121), Yue-Peng Zhou (5337254), Qing-Yang Zhang (1401712), Xing-Jun Jiang (15295118), Min-Hua Luo (522503)   +14 more
core   +1 more source