Results 151 to 160 of about 157,775 (261)

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

International Journal of Cancer, Volume 158, Issue 6, Page 1740-1754, 15 March 2026.
What's new? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta, Marina Fujimoto, Yasuha Hiraoka, Aoi Taniguchi, Yuki Shiiba, Takuto Inoki, Tomoaki Yamauchi, Yuya Yoshida, Naoya Matsunaga, Shigehiro Ohdo, Satoru Koyanagi   +10 more
wiley   +1 more source

Supplementary material from Hypoxic Cancer-Secreted Exosomal miR-182-5p Promotes Glioblastoma Angiogenesis by Targeting Kruppel-like Factor 2 and 4

, 2023
Junjun Li, Hongliang Yuan, Hao Xu, Hongyang Zhao, Nanxiang Xiong   +4 more
openalex   +2 more sources

S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension

Redox Biology, 2019
Krüppel-like factor 4 (KLF4) is a transcription factor with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts a protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation ...
Yiqian Ban, Yahan Liu, Yazi Li, Yuying Zhang, Lei Xiao, Yue Gu, Shaoliang Chen, Beilei Zhao, Chang Chen, Nanping Wang   +9 more
doaj   +1 more source

Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes [PDF]

, 2010
Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells ...
Dandekar, D., De Gendt, K., Hu, Z., O'Shaughnessy, P.J., Verhoeven, G., Wilkinson, M.F.   +5 more
core   +2 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice

Journal of Immunology Research, 2019
CCAAT/enhancer-binding homologous protein (CHOP), a transcriptional regulator induced by endoplasmic reticulum stress (ER stress) is a pivotal factor in the ER stress-mediated apoptosis pathway.
Mengyun Duan, Yuan Yang, Shuang Peng, Xiaoqin Liu, Jixin Zhong, Yurong Guo, Min Lu, Hao Nie, Boxu Ren, Xiangzhi Zhang, Lian Liu   +10 more
doaj   +1 more source

Transcriptional profiling of fetal hypothalamic TRH neurons [PDF]

, 2011
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Castillo-Ramirez, Santiago, Charli, Jean-Louis, Guerra-Crespo, Magdalena, Gutierrez-Rios, Rosa M, Janga, Sarath Chandra, Joseph-Bravo, Patricia, Perez-Martinez, Leonor, Perez-Monter, Carlos   +7 more
core   +4 more sources

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima, Haruko Nakamura, Motokazu Koga, Junka Koyama, Yayoi Kimura, Maya N. Vasishth, Evan Y. Snyder, Masashi Asai, Kenta Sakai, Daiki Masukawa   +9 more
wiley   +1 more source

KLF4 and CD55 expression and function depend on each other

Frontiers in Immunology
The transcription factor Kruppel-like factor 4 (KLF4) regulates the expression of immunosuppressive and anti-thrombotic proteins. Despite its importance in maintaining homeostasis, the signals that control its expression and the mechanism of its ...
Feng-Qi An, Guangjin Zhou, Micah T. Harland, Wasim Hussain, Michael G. Strainic, Mukesh K. Jain, M. Edward Medof   +6 more
doaj   +1 more source

Krüppel‐like factor 4 induces apoptosis and inhibits tumorigenic progression in SK‐BR‐3 breast cancer cells

FEBS Open Bio, 2015
Krüppel‐like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes.
Bing Wang, Ming-zhi Zhao, Nai-peng Cui, Dan-dan Lin, An-yi Zhang, Yan Qin, Cai-yun Liu, Wei-tao Yan, Jian-hong Shi, Bao-ping Chen   +9 more
doaj   +1 more source