Results 171 to 180 of about 157,775 (261)

The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter.

The Journal of biological chemistry, 2000
An important mechanism by which the tumor suppressor p53 maintains genomic stability is to induce cell cycle arrest through activation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene. We show that the gene encoding the gut-enriched Krüppel-like factor (GKLF, KLF4) is concurrently induced with p21(WAF1/Cip1) during serum deprivation and DNA
W, Zhang, D E, Geiman, J M, Shields, D T, Dang, C S, Mahatan, K H, Kaestner, J R, Biggs, A S, Kraft, V W, Yang   +8 more
openaire   +1 more source

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source

Ythdc1‐p300‐Klf5 Complex‐Mediated Golgi Dysfunction Promotes Aortic Aneurysm

Advanced Science, Volume 13, Issue 4, 19 January 2026.
In their Research Article (DOI: https://doi.org/10.1002/advs.202512116* lF: 14.1 Q1), Wenli Wang and co‐workers identifies a novel lncRNA m6A modification‐dependent regulatory mechanism of vascular homeostasis, and constructs a predictive model for post‐operative short‐term death based on AD patient's features, providing a platform to be able to ...
Wen‐Li Wang, Zhi‐Xue Song, Si‐Ming Bu, Yi‐Mei Liu, Qing Li, Wen‐Xia Zhang, Xu‐Rong Sun, Xin Zhang, Yu‐Xuan Xiao, Di Bo, Xu‐Bin Miao, Chao Liu, Xin‐Hua Zhang, Lei Zheng, Hong‐Ye Zhao, Bao‐Lian Zhang, Wen Jia, Kui Chi, Yu Liu, Yong‐Bo Zhao, Bin Zheng, Dong Ma, Jin‐Kun Wen   +22 more
wiley   +1 more source

Krüppel-like transcription factors and control of pluripotency

BMC Biology, 2010
Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant ...
Bourillot Pierre-Yves, Savatier Pierre
doaj   +1 more source

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

Supplementary Figure 2 from Kruppel-like Factor 4 Induces <i>p27^Kip1</i> Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells [PDF]

, 2023
Daoyan Wei, Masahsi Kanai, Zhiliang Jia, Xiangdong Le, Keping Xie   +4 more
openalex   +2 more sources

Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of RORγt [PDF]

, 2010
Lori Lebson, Anne R. Gocke, Jason M. Rosenzweig, Jonathan K. Alder, Curt I. Civin, Peter A. Calabresi, Katharine A. Whartenby   +6 more
openalex   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

miR‐375‐3p/STX6 Exacerbates Atherosclerosis by Promoting Endothelial Cell Senescence via Activation of TGF‐Beta Signals

Aging Cell, Volume 25, Issue 1, January 2026.
miR‐375‐3p promotes endothelial senescence by targeting STX6 and activating the SMAD2/p15 pathway (penal A). Inhibition of miR‐375‐3p or restoration of STX6 alleviates endothelial senescence and reduces atherosclerotic plaque formation in ApoE−/− mice (penal B).
Ying Zhu, Zhirui Liu, Yiqi Wan, Shuangjin Ding, Jiankun Liu, Andong Wu, Ximo Dai, Jin Zhou, Xueer Li, Xueting Gong, Man Liu, Xiao‐Li Tian   +11 more
wiley   +1 more source

Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel-Like Factor 4. [PDF]

J Am Heart Assoc, 2023
Du BB, Zhang JL, Kong LY, Shi HT, Zhang DH, Wang X, Yang CL, Li PC, Yao R, Liang C, Wu LM, Huang Z.   +11 more
europepmc   +1 more source