Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations [PDF]
Nucleic Acids Res. 46, 9895 (2018), 2020 Current models for the folding of the human genome see a hierarchy stretching down from chromosome territories, through A/B compartments and TADs (topologically-associating domains), to contact domains stabilized by cohesin and CTCF. However, molecular mechanisms underlying this folding, and the way folding affects transcriptional activity, remain ...
arxiv
KLF6 and STAT3 Co-Occupy Regulatory DNA and Functionally Synergize to Promote Axon Growth in CNS Neurons [PDF]
, 2018 The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear.
Blackmore, Murray G. +7 more
core +1 more source
Histone-Binding of DPF2 Mediates Its Repressive Role in Myeloid Differentiation [PDF]
, 2017 Double plant homeodomain finger 2 (DPF2) is a highly evolutionarily conserved member of the d4 protein family that is ubiquitously expressed in human tissues and was recently shown to inhibit the myeloid differentiation of hematopoietic stem/progenitor ...
Davenport, Andrew M. +7 more
core +1 more source
Selecting Optimal Combinations of Transcription Factors to Promote Axon Regeneration: Why Mechanisms Matter [PDF]
, 2016 Recovery from injuries to the central nervous system, including spinal cord injury, is constrained in part by the intrinsically low ability of many CNS neurons to mount an effective regenerative growth response.
Blackmore, Murray G. +1 more
core +1 more source
Neurobiology of Disease, 2022 Amyotrophic Lateral Sclerosis (ALS) is a currently incurable disease that causes progressive motor neuron loss, paralysis and death. Skeletal muscle pathology occurs early during the course of ALS. It is characterized by impaired mitochondrial biogenesis,
Ryan Massopust +6 more
doaj
PLoS ONE, 2020 Mast cells have secretory granules containing chemical mediators such as histamine and play important roles in the immune system. Polyamines are essential factors for cellular processes such as gene expression and translation.
Kazuhiro Nishimura +10 more
doaj +1 more source
Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]
, 2008 Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama +4 more
core +1 more source
Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. [PDF]
, 2015 Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways.
Farrar, Katherine +9 more
core +1 more source
Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo [PDF]
, 2016 Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of ...
Berek, Jonathan S +5 more
core +2 more sources
Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.
PLoS Biology, 2020 Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery.
Jia Li +12 more
doaj +1 more source