Results 151 to 160 of about 33,501 (214)

Tcf7l1 promotes transcription of Kruppel-like factor 4 during Xenopus embryogenesis

The Journal of Biomedical Research, 2018
Kruppel-like factor 4 (Klf4) is a zinc finger transcriptionfactor and plays crucial roles in Xenopus embryogenesis. However, its regulation during embryogenesis is stillunclear. Here, we report that Tcf7l1, a key downstream transducerof the Wnt signaling pathway, could promote Klf4 transcription and stimulate Klf4 promoter activity in early Xenopus ...
Cao, Qing, Shen, Yan, Zheng, Wei, Liu, Hao, Liu, Chen   +4 more
openaire   +2 more sources

Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells and Impairs Late Cortical Angiogenesis

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Ethanol exposure alters brain endothelial cell function and blood–brain barrier integrity. In human brain microcapillary endothelial cells (HBMEC) and mouse brain endothelial cells (MBEC) from a prenatal alcohol exposure (PAE) model, ethanol increased DNA methyltransferas‐1 (DNMT1) activity and reduced DNA methylation, affecting DNMT3a/3b, methyl‐CpG ...
Michele Siqueira, Matheus Barros, Paula Lacerda Almeida, Luiza dos Santos Heringer, Henrique Rocha Mendonça, Flávia Carvalho Alcantara Gomes, Joice Stipursky   +6 more
wiley   +1 more source

KLF6 and STAT3 Co-Occupy Regulatory DNA and Functionally Synergize to Promote Axon Growth in CNS Neurons [PDF]

, 2018
The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear.
Blackmore, Murray G., Eastwood, Dan C., Holan, Lyndsey, Maunze, Brian, Mehra, Vatsal, Simpson, Matthew T., Venkatesh, Ishwariya, Wang, Zimei   +7 more
core   +1 more source

Selecting Optimal Combinations of Transcription Factors to Promote Axon Regeneration: Why Mechanisms Matter [PDF]

, 2016
Recovery from injuries to the central nervous system, including spinal cord injury, is constrained in part by the intrinsically low ability of many CNS neurons to mount an effective regenerative growth response.
Blackmore, Murray G., Venkatesh, Ishwariya   +1 more
core   +1 more source

The Regulatory Network of Transcription Factors in Macrophage Polarization

ImmunoTargets and Therapy
Jie Liu,1,2 Mengran Wang,1,2 Yong Zhao1,2 1State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, People’s Republic of ...
Liu J, Wang M, Zhao Y
doaj  

WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism [PDF]

, 2020
Abe, T., Furuya, K., Higami, Y., Hoshino, S., Kawabe, H., Kobayashi, M., Konno, R., Miura, K., Mizunoe, Y., Nakagawa, Y., Nakamura, T., Okita, N., Sudo, Y., Tagawa, R., Wakasawa, H.   +14 more
core   +1 more source

Krüppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration. [PDF]

Mol Cell Neurosci, 2011
Moore DL, Apara A, Goldberg JL.
europepmc   +1 more source

Decoding the Kruppel-like Transcription Factors in Atherosclerosis: Insight from Molecular and Translational Perspectives. [PDF]

Int J Mol Sci
Cao Y, Wang C, Zhu X, Zhan M, Xu J, Jiang M.   +5 more
europepmc   +1 more source

Abnormal expression and potential clinical value of oncogenic Krüppel-like factor-5 in lung squamous cell carcinoma. [PDF]

World J Clin Oncol
Shi Y, Sai WL, Chen JL, Qiu LW, Yao M, Zhao J, Yao DF.   +6 more
europepmc   +1 more source

Editorial: Tumor-host interactions: metabolic and signaling pathways altered in cancer, immune and stromal cells. [PDF]

Front Mol Biosci
Kopecka J, Audrito V.
europepmc   +1 more source