Results 121 to 130 of about 16,928 (247)

TLR4-Mediated Inflammation Promotes KSHV-Induced Cellular Transformation and Tumorigenesis by Activating the STAT3 Pathway.

Cancer Research, 2017
Toll-like receptors (TLR) are conserved immune sensors mediating antimicrobial and antitumoral responses, but recent evidence implicates them in promoting carcinogenesis in certain cancers.
M. Gruffaz, Karthik Vasan, Brandon Tan, Suzane Ramos da Silva, Shou-Jiang Gao   +4 more
semanticscholar   +1 more source

Inhibiting KSHV replication by targeting the essential activities of KSHV processivity protein, PF‐8

Journal of Medical Virology
AbstractKaposi's Sarcoma Herpesvirus (KSHV) is the causative agent of several human diseases. There are no cures for KSHV infection. KSHV establishes biphasic lifelong infections. During the lytic phase, new genomes are replicated by seven viral DNA replication proteins. The processivity factor's (PF‐8) functions to tether DNA polymerase to DNA, so new
Jennifer Kneas Travis, Lindsey M. Costantini   +1 more
openaire   +2 more sources

Sequencing of Kaposi's Sarcoma Herpesvirus (KSHV) genomes from persons of diverse ethnicities and provenances with KSHV-associated diseases demonstrate multiple infections, novel polymorphisms, and low intra-host variance.

PLoS Pathogens
Recently published near full-length KSHV genomes from a Cameroon Kaposi sarcoma case-control study showed strong evidence of viral recombination and mixed infections, but no sequence variations associated with disease.
Vickie A Marshall, Elena M Cornejo Castro, Charles A Goodman, Nazzarena Labo, Isabella Liu, Nicholas C Fisher, Kyle N Moore, Ananthakrishnan Nair, Taina Immonen, Brandon F Keele, Mark N Polizzotto, Thomas S Uldrick, Yunxiang Mu, Tanuja Saswat, Laurie T Krug, Kevin M McBride, Kathryn Lurain, Ramya Ramaswami, Robert Yarchoan, Denise Whitby   +19 more
doaj   +1 more source

T-cell responses to KSHV infection: a systematic approach

OncoTarget, 2017
Prior studies of T-cell responses to KSHV have included relatively few participants and focused on relatively few KSHV antigens. To provide a more comprehensive analysis, we investigated T-cell responses to the whole KSHV proteome using IFN-γ ELISpot ...
Romin Roshan, Nazzarena Labo, Matthew T Trivett, W. Miley, V. Marshall, L. Coren, Elena M. Cornejo Castro, Hannah Perez, B. Holdridge, Eliza Davis, Rodrigo Matus-Nicodemos, V. Ayala, R. Sowder, K. Wyvill, K. Aleman, C. Fennessey, J. Lifson, M. Polizzotto, D. Douek, B. Keele, T. Uldrick, R. Yarchoan, C. Ohlen, D. Ott, D. Whitby   +24 more
semanticscholar   +1 more source

KSHV Entry and Trafficking in Target Cells—Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics

Viruses, 2016
Kaposi’s sarcoma associated herpesvirus (KSHV) is etiologically associated with human endothelial cell hyperplastic Kaposi’s sarcoma and B-cell primary effusion lymphoma.
B. Kumar, B. Chandran
semanticscholar   +1 more source

Kaposi's sarcoma associated herpes virus (KSHV/HHV 8): epidemiology, molecular biology and tissue distribution. [PDF]

, 1997
John O’Leary, M. Kennedy, J O McGee
openalex   +1 more source

KSHV-Mediated Angiogenesis in Tumor Progression

Viruses, 2016
Human herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus (KSHV), is a malignant human oncovirus belonging to the gamma herpesvirus family. HHV-8 is closely linked to the pathogenesis of Kaposi’s sarcoma (KS) and two other B-cell
Pravinkumar Purushothaman, T. Uppal, R. Sarkar, S. Verma   +3 more
semanticscholar   +1 more source

A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway

OncoTarget, 2016
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). Most tumor cells in these malignancies are latently infected by KSHV.
Wan Li, X. Jia, C. Shen, Mi Zhang, Jingyun Xu, Y. Shang, Kaixiang Zhu, Minmin Hu, Q. Yan, D. Qin, Myung-Shin Lee, Jianzhong Zhu, Hongmei Lu, B. Krueger, R. Renne, Shou-Jiang Gao, Chun Lu   +16 more
semanticscholar   +1 more source

Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in South Africa

Infectious Agents and Cancer, 2010
Background Factors previously associated with Kaposi's sarcoma-associated herpesvirus (KSHV) transmission in Africa include sexual, familial, and proximity to river water.
Malope-Kgokong Babatyi I, MacPhail Patrick, Mbisa Georgina, Ratshikhopha Edith, Maskew Mhairi, Stein Lara, Sitas Freddy, Whitby Denise   +7 more
doaj   +1 more source

Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981–1996 [PDF]

, 1998
Mads Melbye, Pamela Cook, Henrik Hjalgrim, Kamilla Begtrup, Guy R. Simpson, Robert J. Biggar, Peter Ebbesen, Thomas F. Schulz   +7 more
openalex   +1 more source