Results 101 to 110 of about 17,773 (204)

Extracellular Vesicles From KSHV-Infected Cells Stimulate Antiviral Immune Response Through Mitochondrial DNA

Frontiers in Immunology, 2019
Kaposi's Sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, which is the most common cancer in acquired immune deficiency syndrome patients. KSHV contains a variety of immunoregulatory proteins. There have been many studies
Hyungtaek Jeon, Jisu Lee, Suhyuk Lee, Su-Kyung Kang, Sang June Park, Seung-Min Yoo, Myung-Shin Lee   +6 more
doaj   +1 more source

Modulators of the Hop-HSP90 Protein-Protein Interaction Disrupt Early-Stage of KSHV Lytic Replication [PDF]

The central role of the chaperome in maintaining cellular proteostasis has seen numerous viral families evolve to parasitically exploit host chaperones in their life cycle. The HSP90 chaperone protein and its co-chaperone Hop, have both individually been
Alhassan, Mahama, Fernando, Albericio, Clinton, Veale, Beatriz, de la Torre, Adrienne, Edkins, Michael, Okpara, Michaelone, Vaaltyn, David, Clarke   +7 more
core   +1 more source

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis [PDF]

, 2018
Kaposi’s sarcoma (KS) herpesvirus (KSHV) causes KS, an angiogenic AIDS-associated spindle-cell neoplasm, by activating host oncogenic signaling cascades through autocrine and paracrine mechanisms.
Cavallin, Lucas E., Julian Naipauer (5492984), Kurian, Mani, Sachin Gupta (528945), Julian Naipauer, Enrique A. Mesri (515944), Paola Locatelli, Goldschmidt-Clermont, Pascal J, Lucas E Cavallin, Sachin Gupta, Pascal J Goldschmidt-Clermont, Romanelli, Paolo, Gupta, Sachin, Paolo Romanelli (5492987), Locatelli, Paola, Mani Kurian (5492975), Lucas E. Cavallin (596052), Naipauer, Julian, Paola Locatelli (5492981), Pascal J. Goldschmidt-Clermont (268053), Paolo Romanelli, Mesri, Enrique A, Ma, Qi, Qi Ma (141685), Cavallin, Lucas E, Mani Kurian, Goldschmidt Clermont, Pascal J., Mehrdad Nadji (5492978), Qi Ma, Mehrdad Nadji, Nadji, Mehrdad, Mesri, Enrique Alfredo, Enrique A Mesri   +32 more
core   +1 more source

The Role of SUMOylation in the KSHV Kaposin B-MK2 Signaling Axis

, 2019
Kaposi’s sarcoma (KS) is characterized by infection with Kaposi’s sarcoma associated herpesvirus (KSHV), aberrant inflammation and cell spindling. These phenotypes are recapitulated by expression of the viral gene product Kaposin B (KapB). KapB binds and
Veinot, Sarah
core  

Kaposi’s Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes

mBio, 2017
Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with the human malignancy Kaposi’s sarcoma and the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman’s disease. KSHV establishes lytic infection of monocytes in
Kurtis M. Host, Sarah R. Jacobs, John A. West, Zhigang Zhang, Lindsey M. Costantini, Charles M. Stopford, Dirk P. Dittmer, Blossom Damania   +7 more
doaj   +1 more source

CONTROL OF STRESS RESPONSES BY VIRAL AND CELLULAR BASIC LEUCINE ZIPPER TRANSCRIPTION FACTORS

, 2022
Glycoproteins are processed through the secretory pathway and require folding in the endoplasmic reticulum (ER). When unfolded proteins accumulate in the ER, the sensor protein ATF6 is activated, translocated to the Golgi, and proteolytically processed ...
Stolz, Madeleine Lota
core  

Plasmacytic markers as immunotherapeutic targets for primary CD20‐negative aggressive B‐cell lymphomas

British Journal of Haematology, Volume 209, Issue 1, Page 300-305, July 2026.
Frank Neumann, Claudia Schormann, Onur Cetin, Igor A. Kos, Moritz Bewarder, Eva C. Schwarz, Stefan Lohse, Stephanie Maurer, Philipp B. Staber, Joerg T. Bittenbring, Sigrun Smola, Konstantinos Christofyllakis, Markus Hoth, Lorenz Thurner   +13 more
wiley   +1 more source

Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.

PLoS Pathogens, 2012
KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded miRNAs are readily detectable in all KSHV-associated tumors suggests a potential ...
Irina Haecker, Lauren A Gay, Yajie Yang, Jianhong Hu, Alison M Morse, Lauren M McIntyre, Rolf Renne   +6 more
doaj   +1 more source

Inhibiting KSHV replication by targeting the essential activities of KSHV processivity protein, PF‐8

Journal of Medical Virology
Abstract Kaposi's Sarcoma Herpesvirus (KSHV) is the causative agent of several human diseases. There are no cures for KSHV infection. KSHV establishes biphasic lifelong infections. During the lytic phase, new genomes are replicated by seven viral DNA replication proteins.
Jennifer Kneas Travis, Lindsey M. Costantini   +1 more
openaire   +2 more sources

KSHV LANA's expanding bag of tricks

Blood, 2008
In this issue of Blood, Di Bartolo and colleagues report that KSHV targets the TGF-β signaling pathway in latently infected tumor cells.
Andrew J, Barbera, Kenneth M, Kaye
openaire   +3 more sources