Results 121 to 130 of about 22,605 (225)

Inhibition of a viral enzyme by a small-molecule dimer disruptor. [PDF]

, 2009
We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi's sarcoma-associated herpesvirus (KSHV) by screening an alpha-helical mimetic library.
Arnold, Leggy A, Craik, Charles S, Guy, R Kiplin, Lazic, Ana, Lee, Gregory M, Roels, Christina M, Shahian, Tina, Velusamy, Priya   +7 more
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The functions of herpesvirus-encoded microRNAs [PDF]

, 2008
Bioinformatic and direct cloning approaches have led to the identification of over 100 novel miRNAs expressed in DNA viruses, although the function of the majority of these small regulatory RNA molecules is unclear. Recently, a number of reports have now
Grey, Finn, Hook, Lauren, Nelson, Jay
core   +1 more source

Inhibiting KSHV replication by targeting the essential activities of KSHV processivity protein, PF‐8

Journal of Medical Virology
AbstractKaposi's Sarcoma Herpesvirus (KSHV) is the causative agent of several human diseases. There are no cures for KSHV infection. KSHV establishes biphasic lifelong infections. During the lytic phase, new genomes are replicated by seven viral DNA replication proteins. The processivity factor's (PF‐8) functions to tether DNA polymerase to DNA, so new
Jennifer Kneas Travis, Lindsey M. Costantini   +1 more
openaire   +2 more sources

Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.

PLoS Pathogens, 2012
KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded miRNAs are readily detectable in all KSHV-associated tumors suggests a potential ...
Irina Haecker, Lauren A Gay, Yajie Yang, Jianhong Hu, Alison M Morse, Lauren M McIntyre, Rolf Renne   +6 more
doaj   +1 more source

Sequencing of Kaposi's Sarcoma Herpesvirus (KSHV) genomes from persons of diverse ethnicities and provenances with KSHV-associated diseases demonstrate multiple infections, novel polymorphisms, and low intra-host variance.

PLoS Pathogens
Recently published near full-length KSHV genomes from a Cameroon Kaposi sarcoma case-control study showed strong evidence of viral recombination and mixed infections, but no sequence variations associated with disease.
Vickie A Marshall, Elena M Cornejo Castro, Charles A Goodman, Nazzarena Labo, Isabella Liu, Nicholas C Fisher, Kyle N Moore, Ananthakrishnan Nair, Taina Immonen, Brandon F Keele, Mark N Polizzotto, Thomas S Uldrick, Yunxiang Mu, Tanuja Saswat, Laurie T Krug, Kevin M McBride, Kathryn Lurain, Ramya Ramaswami, Robert Yarchoan, Denise Whitby   +19 more
doaj   +1 more source

To reactivate or not to reactivate : Control of KSHV lytic replication is essential for apoptosis in response to p53 restoration [PDF]

, 2010
Kaposi's sarcoma herpesvirus (KSHV) is an oncogenic human virus and the causative agent of three human malignancies: Kaposi's sarcoma (KS), Multicentric Castleman's Disease (MCD), and primary effusion lymphoma (PEL).
Sarek, Grzegorz
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Factors affecting Kaposi’s sarcoma-associated herpesvirus transmission in rural Ugandan households, a longitudinal study

Infectious Agents and Cancer
Background We report the impact of HIV infection within a household on oral Kaposi’s sarcoma-associated herpesvirus (KSHV) shedding. Methods We enrolled 469 individuals from 90 households.
Katherine R. Sabourin, Vickie A. Marshall, Will Eaton, Beatrice Kimono, Joseph Mugisha, Wendell J. Miley, Nazzarena Labo, Gabriela Samayoa-Reyes, Denise Whitby, Rosemary Rochford, Robert Newton   +10 more
doaj   +1 more source

The Role of vIL-6 in KSHV-Mediated Immune Evasion and Tumorigenesis

Viruses
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA gamma herpesvirus. Like other herpesviruses, KSHV establishes a latent infection with limited gene expression, while KSHV occasionally undergoes the lytic replication phase, which ...
Somayeh Komaki, Tomoki Inagaki, Ashish Kumar, Yoshihiro Izumiya   +3 more
doaj   +1 more source

KSHV [PDF]

, 2014
Louise Giffin, Blossom Damania
openaire   +1 more source

Regulation of members of the angiopoietin family by Kaposi sarcoma herpesvirus [PDF]

, 2008
Kaposi sarcoma herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (KS), a vascular tumour of endothelial cells. The angiopoictin family arc a group of secreted glycoproteins whose members play important roles in tumour vascularisation.
Vart, RJ
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