Results 81 to 90 of about 17,773 (204)

Characterising the adaptive t-cell immune response against Kaposi’s sarcoma-associated herpesvirus [PDF]

, 2010
Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi’s sarcoma (KS), the most common malignancy in individuals with untreated HIV/AIDS.
Robey, R.C.
core  

Cellular microRNAs 498 and 320d regulate herpes simplex virus 1 induction of Kaposi's sarcoma-associated herpesvirus lytic replication by targeting RTA. [PDF]

PLoS ONE, 2013
Kaposi's sarcoma-associated herpesvirus (KSHV) infection was necessary but not sufficient for KS development without other cofactors. We have previously reported that herpes simplex virus (HSV)-1 was an important cofactor that reactivated KSHV from ...
Qin Yan, Wan Li, Qiao Tang, Shuihong Yao, Zhigang Lv, Ninghan Feng, Xinting Ma, Zhiqiang Bai, Yi Zeng, Di Qin, Chun Lu   +10 more
doaj   +1 more source

Ginseng as a Functional Food Intervention for Interstitial Lung Disease: A Review of the Benefits and Molecular Mechanisms

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
From the perspectives of food science and nutrition, this article reviews the regulatory mechanisms through which ginseng and its major components influence ILD‐related pathological processes and discusses its potential as a functional food and future research directions. ABSTRACT Interstitial lung disease (ILD) encompasses a complex group of disorders
Jiahui Li, Guixin Di, Haijiao Wang, Mengzhu Chen, Keju Wang, Ziyuan Wang, Yanxin Li, Tan Wang   +7 more
wiley   +1 more source

KSHV and the toll of innate immune activation [PDF]

Cell Cycle, 2009
Comment on: Gregory SM, West JA, Dillon PJ, Hilscher C, Dittmer DP, Damania B. Toll-like receptor signaling controls reactivation of KSHV from latency. Proc Natl Acad Sci USA 2009; 106:11725-30.
Sean M, Gregory, Blossom, Damania
openaire   +2 more sources

Selective autophagy impedes KSHV entry after recruiting the membrane damage sensor galectin-8 to virus-containing endosomes

Cell Reports
Summary: Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus. Autophagy during KSHV entry has remained unexplored. We show that LC3 lipidation as a hallmark of autophagy is induced shortly after KSHV entry.
Katarina Wendy Schmidt, Charlotte Montespan, Danielle Thompson, Miriam S. Lucas, Laure-Anne Ligeon, Harald Wodrich, Alexander S. Hahn, Urs F. Greber, Christian Münz   +8 more
doaj   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation

, 2019
Kaposi’s sarcoma associated herpesvirus (KSHV), like all herpesviruses maintains lifelong persistence with its host genome in latently infected cells with only a small fraction of cells showing signatures of productive lytic replication.
Jianxin You (121729), Yan Yuan (20767), Yan Yuan, Erle S. Robertson (7340108), Zachary L Lamplugh, Paul Lieberman, Fengchao Lang (5205029), Rajnish Kumar Singh, Jianxin You, Erle S Robertson, Paul Lieberman (7340105), Fengchao Lang, Zachary L. Lamplugh (6180686), Rajnish Kumar Singh (5205032)   +13 more
core   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 39, 13 July 2026.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Molecular and Phylogenetic Characterization of HTLV‐1 Infection in Patients With Hematological Malignancies in the State of Pará, Northern Brazil

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Human T‐lymphotropic viruses 1 and 2 (HTLV‐1 and HTLV‐2) were first isolated from patients with hematological malignancies. This study was the first to investigate the frequency of HTLV‐1 and its molecular diversity among patients with hematolymphoid cancers who were treated at a leading reference hospital in Pará, northern Brazil.
Gabriel dos Santos Pereira Neto, Ana Vilhena Alves, Bruno José Sarmento Botelho, Andrio Silva da Silva, Debora Monteiro Carneiro, Rommel Mario Rodriguez Burbano, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Izaura Maria Vieira Cayres Vallinoto   +8 more
wiley   +1 more source