Results 61 to 70 of about 17,773 (204)
Cytokine-Targeted Therapeutics for KSHV-Associated Disease
Viruses, 2020 Kaposi’s sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman’s disease (MCD) and recently KSHV ...
Nedaa Alomari, Jennifer Totonchy
doaj +1 more source
The Role of Viruses in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte +2 more
wiley +1 more source
miRNAs and their roles in KSHV pathogenesis
Virus Research, 2019 Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman Disease (MCD). Recent mechanistic advances have discerned the importance of microRNAs in the virus-host relationship. KSHV has two modes of replication: lytic and latent phase.
Hosni A M, Hussein +6 more
openaire +2 more sources
Viruses, Periodontitis, and Systemic Diseases
Journal of Periodontal Research, EarlyView.This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte +2 more
wiley +1 more source
Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]
, 2010 Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Kafka, Darren +37 more
core +1 more source
Identification of Target Genes Regulated by KSHV miRNAs in KSHV-Infected Lymphoma Cells
Pathology & Oncology Research, 2015 This study aimed to identify target genes regulated by KSHV miRNAs in KSHV-infected lymphoma cells. Original Ago HITS-CLIP data of BC-3 and BCBL-1 cell lines were downloaded from SRA database in NCBI, including mRNA and miRNA samples. The raw mRNA reads were mapped into human reference genome hg19 via TopHat for read alignment.
Liangliang, Quan +5 more
openaire +2 more sources
Persistence of Kaposi Sarcoma–Associated Herpesvirus (KSHV)–Infected Cells in KSHV/HIV‐1–Coinfected Subjects without KSHV‐Associated Diseases [PDF]
The Journal of Infectious Diseases, 2005 Inguinal lymph nodes from 24 human immunodeficiency virus (HIV) type 1-infected subjects without Kaposi sarcoma-associated herpesvirus (KSHV)-associated diseases were examined for KSHV infection. KSHV-infected cells were detected at a very low frequency in the lymph nodes of 7 subjects (median frequency, 2 infected cells/10(7) lymph node cells). Latent,
Thomas B, Campbell +6 more
openaire +2 more sources
Transplant Infectious Disease, EarlyView.Among 135 cases of post‐liver transplant HHV8 disease (4 from NSW), presentations varied, and mortality was high (44%). Donor screening was rare, and donor‐derived infection was suspected in 33%. Survival improved with mTORi, reduced immunosuppression, chemotherapy, and, for non‐KS disease, donor screening. ABSTRACT Background Human herpesvirus 8 (HHV8)
Karen M. J. Waller +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 50, 7 September 2026.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
KSHV-mediated PDGF upregulation and PDGFRA activation in mECK36 cells and tumors.
, 2018 (A) Fold-changes in KSHV gene expression and PDGFRA ligands between mECK36 cells and mECK36 tumors determined by RT-qPCR in triplicate and are presented as means ± SD. *P B) Total and phospho-PDGFRA together with its ligands PDGFA and PDGFB determined by
Julian Naipauer (5492984) +9 more
core +1 more source