Results 61 to 70 of about 22,605 (225)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Lack of CD8+ T-cell co-localization with Kaposi’s sarcoma- associated herpesvirus infected cells in Kaposi’s sarcoma tumors [PDF]

, 2020
Despite the close association between Kaposi’s sarcoma (KS) and immune dysfunction, it remains unclear whether tumor infiltrating immune cells (TIIC), by their absence, presence, or dysfunction, are mechanistically correlated with KS pathogenesis ...
Kolape, Jaydeep, Lidenge, Salum J., Mwaiselage, Julius, Ngalamika, Owen, Ngowi, John R., Tso, For Yue, West, John T., Wood, Charles   +7 more
core   +1 more source

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]

, 2018
G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core   +1 more source

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Cell death inhibition by KSHV

Aging, 2015
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of the endothelial cell-derived tumor Kaposi's sarcoma and of the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman's disease. The life cycle of KSHV includes a latent and a lytic/productive phase that both contribute to tumorigenic activity.
Vinay, Murtadak, Christoph, Becker, Michael, Stürzl   +2 more
openaire   +2 more sources

Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection.

PLoS Pathogens, 2022
Polyamines are critical metabolites involved in various cellular processes and often dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined human oncogenic virus, leads to profound alterations of host metabolic landscape to ...
Guillaume N Fiches, Zhenyu Wu, Dawei Zhou, Ayan Biswas, Tai-Wei Li, Weili Kong, Maxime Jean, Netty G Santoso, Jian Zhu   +8 more
doaj   +1 more source

A portable device for nucleic acid quantification powered by sunlight, a flame or electricity. [PDF]

, 2018
A decentralized approach to diagnostics can decrease the time to treatment of infectious diseases in resource-limited settings. Yet most modern diagnostic tools require stable electricity and are not portable.
Cesarman, Ethel, Duru, Jens, Erickson, David, Gardner, Andrea, Kopparthy, Varun Lingaiah, Martin, Jeffrey, Maurer, Toby, Semeere, Aggrey, Snodgrass, Ryan   +8 more
core   +1 more source

Co-infection EBV/KSHV [PDF]

médecine/sciences, 2018
Le virus herpétique humain associé au sarcome de Kaposi (KSHV) est l’agent étiologique du lymphome primitif des séreuses (PEL) dans lequel le virus d’Epstein-Barr (EBV) est aussi très souvent présent. Jusqu’à présent, seuls des modèles cellulaires permettaient d’explorer l’interaction des deux virus conduisant à la transformation des cellules.
Henri Gruffat, Evelyne Manet
openaire   +1 more source

HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV Study

Infectious Agents and Cancer, 2010
Kaposi sarcoma-associated herpesvirus (KSHV, also called Human herpesvirus 8 or HHV8) is a γ-2 herpesvirus that causes Kaposi sarcoma. KSHV seroprevalence rates vary geographically with variable rates recorded in different sub Sahara African countries ...
Figueiredo Constança, Bhatia Kishor, Bakaki Paul M, Owor Anchilla M, Ndugwa Christopher M, Schulz Thomas F, Pfeiffer Ruth M, Verboom Murielle, Guech-Ongey Mercy, Eiz-Vesper Britta, Blasczyk Rainer, Mbulaiteye Sam M   +11 more
doaj   +1 more source

Isolated Pleural Effusion as Presentation of a Large B‐Cell Lymphoma: A Case Report and Diagnostic Considerations

Journal of Clinical Laboratory Analysis, EarlyView.
A 79‐year‐old man presented with massive pleural effusion in which cytological examination revealed lymphoma cells without evidence of a solid tumor mass. Negative EBV in situ hybridization and negative HHV8 and HIV testing, combined with flow cytometric immunophenotyping and molecular findings, supported a diagnosis of fluid overload–associated large ...
Van Vlierberghe Magalie, Dewaide Rosina, Michaux Lucienne, Develter Wim, Van Aelst Sophie, Claerhout Helena   +5 more
wiley   +1 more source