Head &Neck, EarlyView.ABSTRACT Background To characterize the clinicoepidemiologic profile of HIV‐associated oral Kaposi sarcoma (OKS) and quantitatively synthesize its frequency, anatomical distribution, and temporal patterns across antiretroviral therapy (ART) eras. Methods Six databases and gray literature were searched.
Ericles Otávio +10 more
wiley +1 more source
RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms
The FEBS Journal, EarlyView.RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon +4 more
wiley +1 more source
KSHV-infected Igκ+ lymphocytes become Igλ+ via an isotypically included intermediate.
, 2018 Primary naïve B lymphocytes were magnetically sorted from total tonsil lymphocytes, then subsequently flow sorted based on light chain expression and infected with KSHV or mock-infected.
Jessica M. Osborn (436508) +6 more
core +1 more source
Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stress. [PDF]
, 2010 Upregulation of xCT, the inducible subunit of a membrane-bound amino acid transporter, replenishes intracellular glutathione stores to maintain cell viability in an environment of oxidative stress.
Mohan Sarumathi +38 more
core +1 more source
Unmasking the Influence of Viral Micro‐RNAs on Host Immunity
Immunology &Cell Biology, EarlyView.Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton +1 more
wiley +1 more source
, 2019 (A) ChIP-qPCR analysis of H3K4-me3 and H3K27-me3 in KSHV-BAC16Δ73-infected MLE12 cells that had been stably transduced with lentiviral mLANA or kLANA expression constructs.
Lia Burkhardt (824184) +6 more
core +1 more source
The Role of Viruses in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte +2 more
wiley +1 more source
Characterising the adaptive t-cell immune response against Kaposi’s sarcoma-associated herpesvirus [PDF]
, 2010 Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi’s sarcoma (KS), the most common malignancy in individuals with untreated HIV/AIDS.
Robey, R.C.
core
KSHV-mediated PDGF upregulation and PDGFRA activation in mECK36 cells and tumors.
, 2018 (A) Fold-changes in KSHV gene expression and PDGFRA ligands between mECK36 cells and mECK36 tumors determined by RT-qPCR in triplicate and are presented as means ± SD. *P B) Total and phospho-PDGFRA together with its ligands PDGFA and PDGFB determined by
Julian Naipauer (5492984) +9 more
core +1 more source
The relationship of adenoviruses to the DNA damage response protein BLM & Understanding the modulation of DNA repair pathways by the human oncogenic virus KSHV [PDF]
, 2011 Project 1: Adenoviruses (Ad) are able to interact with a number of proteins involved in the cellular response to DNA damage, in order to prevent concatamerisation of the viral genome and inhibition of viral replication.
Ryan, Ellis
core +4 more sources