Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. [PDF]
PLoS Pathogens, 2011 Kaposi's sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the host following an acute infection. Reactivation from latency contributes to the development of KSHV-induced malignancies, which include Kaposi's sarcoma (KS), the most ...
Fengchun Ye +7 more
doaj +1 more source
The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
, 2015 This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
core +1 more source
Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy [PDF]
, 2017 KSHV and EBV are gammaherpesviruses strictly linked to human cancers. Even if the majority of cancer cells harbor a latent infection, the few cells that undergo viral replication may contribute to the pathogenesis and maintenance of the virus-associated ...
Cirone, Mara +7 more
core +2 more sources
Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future [PDF]
, 2015 Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
CIRONE, Mara +6 more
core +4 more sources
A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy
Signal Transduction and Targeted Therapy, 2023 Dilated cardiomyopathy (DCM) is the leading cause of heart transplantation. By microRNA (miRNA) array, a Kaposi’s sarcoma-associated herpes virus (KSHV)-encoded miRNA, kshv-miR-K12-1-5p, was detected in patients with DCM.
Yanru Zhao +17 more
doaj +1 more source
Frontiers in Microbiology, 2021 Kaposi’s sarcoma-associated herpesvirus (KSHV) is an etiologic agent of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman disease. In studies of KSHV, efficient virus production and isolation are essential.
Su-Kyung Kang +5 more
doaj +1 more source
Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy
BMC Cancer, 2023 Chronic infection with Kaposi’s sarcoma-associated herpes virus (KSHV) in B lymphocytes causes primary effusion lymphoma (PEL), the most aggressive form of KSHV-related cancer, which is resistant to conventional chemotherapy.
Tetsunori Sakamoto +5 more
doaj +1 more source
Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections. [PDF]
, 2018 The CRISPR/Cas9 system has been applied in the genome editing and disruption of latent infections for herpesviruses such as the herpes simplex virus, Epstein⁻Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus.
Chen, Yuan-Chuan +3 more
core +2 more sources
Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation [PDF]
, 2013 Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13
Ahmad +53 more
core +1 more source
Persistence of Kaposi Sarcoma–Associated Herpesvirus (KSHV)–Infected Cells in KSHV/HIV‐1–Coinfected Subjects without KSHV‐Associated Diseases [PDF]
The Journal of Infectious Diseases, 2005 Inguinal lymph nodes from 24 human immunodeficiency virus (HIV) type 1-infected subjects without Kaposi sarcoma-associated herpesvirus (KSHV)-associated diseases were examined for KSHV infection. KSHV-infected cells were detected at a very low frequency in the lymph nodes of 7 subjects (median frequency, 2 infected cells/10(7) lymph node cells). Latent,
Thomas B, Campbell +6 more
openaire +2 more sources