Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV–MCD) and the KSHV Inflammatory Cytokine Syndrome [PDF]
Frontiers in Microbiology, 2012 Soon after the discovery of Kaposi sarcoma (KS)-associated herpesvirus (KSHV), it was appreciated that this virus was associated with most cases of multicentric Castleman disease (MCD) arising in patients infected with human immunodeficiency virus.
Mark N. Polizzotto +3 more
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High-throughput sequencing analysis of a "hit and run" cell and animal model of KSHV tumorigenesis. [PDF]
PLoS Pathogens, 2020 Kaposi's sarcoma (KS), is an AIDS-associated neoplasm caused by the KS herpesvirus (KSHV/ HHV-8). KSHV-induced sarcomagenesis is the consequence of oncogenic viral gene expression as well as host genetic and epigenetic alterations. Although KSHV is found
Julian Naipauer +7 more
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Cytokine-Targeted Therapeutics for KSHV-Associated Disease [PDF]
Viruses, 2020 Kaposi’s sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman’s disease (MCD) and recently KSHV ...
Nedaa Alomari, Jennifer Totonchy
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PLoS Pathogens, 2022 Polyamines are critical metabolites involved in various cellular processes and often dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined human oncogenic virus, leads to profound alterations of host metabolic landscape to ...
Guillaume N Fiches +8 more
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Heterogeneity and breadth of host antibody response to KSHV infection demonstrated by systematic analysis of the KSHV proteome. [PDF]
PLoS Pathogens, 2014 The Kaposi sarcoma associated herpesvirus (KSHV) genome encodes more than 85 open reading frames (ORFs). Serological evaluation of KSHV infection now generally relies on reactivity to just one latent and/or one lytic protein (commonly ORF73 and K8.1 ...
Nazzarena Labo +12 more
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kshv-mir-k12-1-5p promotes cell growth and metastasis by targeting SOCS6 in Kaposi’s sarcoma cells
Cancer Management and Research, 2019 Jing Zhang,1,2 Xiong-Ming Pu,3 Yan Xiong41Postgraduate College of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China; 2Department of Pathology, Affiliated Traditional Chinese Medicine Hospital, Xinjiang Medical University ...
Zhang J, Pu XM, Xiong Y
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Understanding KSHV vIRF-2-cell interactions [PDF]
, 2011 Kaposi’s sarcoma-associated herpes virus (KSHV) encodes genes with immunomodulatory potential, one of which is vIRF-2 that shares homology to cellular interferon regulatory factors.
Mutocheluh, Mohamed
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KSHV-LANA breadth and magnitude compared between EnKS, EpKS, and HIV-/HIV+ asymptomatic individuals.
, 2022 The number of reactive peptides and their magnitudes per individual was calculated and compared across disease states, in each group, and across each region within LANA, respectively.
Sydney J. Bennett (10232183) +6 more
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Frontiers in Microbiology, 2021 Kaposi’s sarcoma-associated herpesvirus (KSHV) is the most common cause of Kaposi’s sarcoma (KS) and other malignant growths in humans. However, the lack of a KSHV-infected small animal model has hampered understanding of the mechanisms of KSHV infection,
Daoqun Li +9 more
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NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. [PDF]
, 2015 Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which are aggressive malignancies associated with immunocompromised patients.
Wood, Jennifer J +25 more
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