Results 131 to 140 of about 24,542 (261)

Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments.

PLoS Pathogens, 2015
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic herpesvirus associated with various AIDS-related malignancies. Like other herpesviruses, multiple processes required for KSHV lytic replication, including viral transcription, viral DNA ...
Belinda Baquero-Pérez, Adrian Whitehouse   +1 more
doaj   +1 more source

The interplay between viral-derived miRNAs and host immunity during infection [PDF]

, 2019
MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection.
Ingle, Harshad, Kumar, Ashish, Kumar, Himanshu, Mishra, Richa   +3 more
core   +1 more source

KSHV SOX mediated host shutoff: the molecular mechanism underlying mRNA transcript processing. [PDF]

, 2017
Onset of the lytic phase in the KSHV life cycle is accompanied by the rapid, global degradation of host (and viral) mRNA transcripts in a process termed host shutoff. Key to this destruction is the virally encoded alkaline exonuclease SOX.
Bagnéris, Claire, Barrett, Tracey E, Ebrahimi, Bahram, Lee, Hyunah, Nobeli, Irene, Patschull, Anathe O M, Ryan, Hannah, Sanderson, Christopher M   +7 more
core   +3 more sources

KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

, 2021
Rajnish Kumar Singh, Yonggang Pei, Dipayan Bose, Zachary L Lamplugh, Kunfeng Sun, Yan Yuan, Paul M. Lieberman, Jianxin You, Erle S. Robertson   +8 more
openalex   +1 more source

The functions of herpesvirus-encoded microRNAs [PDF]

, 2008
Bioinformatic and direct cloning approaches have led to the identification of over 100 novel miRNAs expressed in DNA viruses, although the function of the majority of these small regulatory RNA molecules is unclear. Recently, a number of reports have now
Grey, Finn, Hook, Lauren, Nelson, Jay
core   +1 more source

Inhibiting KSHV replication by targeting the essential activities of KSHV processivity protein, PF‐8

Journal of Medical Virology
AbstractKaposi's Sarcoma Herpesvirus (KSHV) is the causative agent of several human diseases. There are no cures for KSHV infection. KSHV establishes biphasic lifelong infections. During the lytic phase, new genomes are replicated by seven viral DNA replication proteins. The processivity factor's (PF‐8) functions to tether DNA polymerase to DNA, so new
Jennifer Kneas Travis, Lindsey M. Costantini   +1 more
openaire   +2 more sources

The m6A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay [PDF]

, 2021
Daniel Macveigh-Fierro, Angelina M. Cicerchia, Ashley Cadorette, Vasudha Sharma, Mandy Muller   +4 more
openalex   +1 more source

A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion [PDF]

, 2017
The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many
Beatrice Plougastel-Douglas, Daved H. Fremont, David Wang, Elvin J. Lauron, Eugene Park, Guoyan Zhao, Ian B. Harvey, Jennifer Poursine-Laurent, Swapneel J. Patel, Vinay R. Penna, Wandy L. Beatty, Wayne M. Yokoyama   +11 more
core   +2 more sources

Sequencing of Kaposi's Sarcoma Herpesvirus (KSHV) genomes from persons of diverse ethnicities and provenances with KSHV-associated diseases demonstrate multiple infections, novel polymorphisms, and low intra-host variance.

PLoS Pathogens
Recently published near full-length KSHV genomes from a Cameroon Kaposi sarcoma case-control study showed strong evidence of viral recombination and mixed infections, but no sequence variations associated with disease.
Vickie A Marshall, Elena M Cornejo Castro, Charles A Goodman, Nazzarena Labo, Isabella Liu, Nicholas C Fisher, Kyle N Moore, Ananthakrishnan Nair, Taina Immonen, Brandon F Keele, Mark N Polizzotto, Thomas S Uldrick, Yunxiang Mu, Tanuja Saswat, Laurie T Krug, Kevin M McBride, Kathryn Lurain, Ramya Ramaswami, Robert Yarchoan, Denise Whitby   +19 more
doaj   +1 more source

Factors affecting Kaposi’s sarcoma-associated herpesvirus transmission in rural Ugandan households, a longitudinal study

Infectious Agents and Cancer
Background We report the impact of HIV infection within a household on oral Kaposi’s sarcoma-associated herpesvirus (KSHV) shedding. Methods We enrolled 469 individuals from 90 households.
Katherine R. Sabourin, Vickie A. Marshall, Will Eaton, Beatrice Kimono, Joseph Mugisha, Wendell J. Miley, Nazzarena Labo, Gabriela Samayoa-Reyes, Denise Whitby, Rosemary Rochford, Robert Newton   +10 more
doaj   +1 more source