Results 111 to 120 of about 43,811 (246)

Intestinal epithelial injury and inflammation after physical work in temperate and hot environments in older men with hypertension or type 2 diabetes

Experimental Physiology, EarlyView.
Abstract We tested whether older adults with well‐controlled type 2 diabetes or hypertension, compared with age‐matched adults without chronic disease, exhibit greater intestinal damage, microbial translocation and inflammation during exertional heat stress.
Ben J. Lee, Tessa R. Flood, Sophie L. Russell, James J. McCormick, Kelli E. King, Naoto Fujii, Tatsuro Amano, Sean Notley, Glen P. Kenny   +8 more
wiley   +1 more source

Th2-Associated Alternative Kupffer Cell Activation Promotes Liver Fibrosis without Inducing Local Inflammation

International Journal of Biological Sciences, 2011
Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound ...
Giuliana López-Navarrete, Espiridión Ramos-Martínez, Karina Suárez-Álvarez, Jesús Aguirre-García, Yadira Ledezma-Soto, Sonia León-Cabrera, Marco Gudiño-Zayas, Carolina Guzmán, Gabriela Gutiérrez-Reyes
doaj  

The impact of a Western diet and binge drinking on metabolic dysfunction‐associated steatotic liver disease in male and female mice

Experimental Physiology, EarlyView.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major public health concern, largely driven by the high‐fat, high‐sugar and low‐fibre Western diet. The Western diet is often accompanied by binge drinking, or the rapid consumption of alcohol in a short time leading to a blood alcohol concentration of ≥0.08%.
Ihsan Shawki Akili, Corina Miko, Azhar Saeed, Colby Filosa, Madeline Orlowski, Alanna Sherman, Aldi Chan, Madison Wan, Jake Grenon, Alec Thibeault, Catherine Young, Melinda Wetzel, Virginia Clubb, Matthew A. Caporizzo, R. Chris Skinner   +14 more
wiley   +1 more source

Variants in AKR1D1 and Infant Mortality: Should Bile Acid Screening be a Routine Part of Newborn Screening?

American Journal of Medical Genetics Part A, Volume 200, Issue 4, Page 971-977, April 2026.
ABSTRACT Biallelic pathogenic variants in AKR1D1 cause Δ4‐3‐oxosteroid 5β‐reductase deficiency, disrupt bile acid synthesis, and result in Congenital Bile Acid Synthesis defect type 2 (CBAS2). CBAS2 presents in infancy with cholestasis, coagulopathy, and failure to thrive.
Jade Hudson, Stephanie Hyunh, Bojana Rakic, Cornelius Boerkoel   +3 more
wiley   +1 more source

Kupffer cells biomimetic nanoparticles alleviate sepsis related liver injury. [PDF]

J Nanobiotechnology
Ma C, Zhou Y, Yang Z, Wang J, Zhu L, Chen H, Wang Y, Wang H, Sun J, Chen X, Zhou W, Li X, Liu L.   +12 more
europepmc   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Protective Mechanism of Auricularia auricula Polysaccharides Against Acute Alcoholic Liver Injury Is Related to Different Consumption Doses

eFood, Volume 7, Issue 2, April 2026.
The study investigated the protective mechanisms of low‐, medium‐, and high‐dose Auricularia auricula polysaccharide (AAP) against acute alcoholic liver injury (AALI) by correlating hepatic biochemical indices with intestinal flora. ABSTRACT This study investigated the dose‐dependent protective effects of Auricularia auricula polysaccharides (AAP ...
Haili Niu, Fangjia Zhao, Zeyu Hu, Qi Wang, Yuan Li, Ivan Kurtovic, Yahong Yuan, Tianli Yue   +7 more
wiley   +1 more source

Kupffer cells are essential for platelet-mediated thrombopoietin generation in the liver. [PDF]

Proc Natl Acad Sci U S A
Karakas D, Li J, Ma W, Wu XG, Khoury CJ, Masoud M, Hoard B, Liu YJ, Zhu G, Chen J, Sim M, Shen C, López JA, MacParland SA, Kahr WHA, Ni H.   +15 more
europepmc   +1 more source

Kupffer Cell [PDF]

, 2020
openaire   +1 more source

Liver Cirrhosis and In‐Hospital Outcomes in Patients With Sickle Cell Crises

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Sickle cell disease (SCD) is a hematologic disorder characterized by chronic hemolysis, vaso‐occlusion, and end‐organ dysfunction. Patients with SCD may experience acute episodes known as sickle cell crises, which are sudden, severe complications typically involving pain or organ‐specific manifestations resulting from vaso ...
Shakirat Gold‐Olufadi, Kayode Ogunniyi, Adeleke Oluwaseun Dorcas, Bukola Florence Tabiti, Dosbai Saparov, Chiamaka Nwachukwu, Henry Becerra, Sravani Bhavanam, Shrestha Neharika, John Ogedegbe, Ifeanyi Nnamdi Uche, Jen Chin Wang, Chinemerem Martlin Emeasoba, Dania Jaamour, Toluwalase Awoyemi   +14 more
wiley   +1 more source