Results 131 to 140 of about 43,811 (246)

Commentary on "Desialylated Platelets Maintain Immune Quiescence through Regulating Kupffer Cells". [PDF]

Research (Wash D C), 2023
Li C, Morrell CN.
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, Volume 20, Issue 3, Page 668-687, March 2026.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitis. [PDF]

Cell Mol Immunol
Wang Y, Guan Y, Feng D, Maccioni L, Parra MA, Peiffer B, Mackowiak B, Kuwabara T, Mori K, Mukoyama M, Bataller R, Sun Z, Gao B.   +12 more
europepmc   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, Volume 38, Issue 13, 3 March 2026.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

C/EBPβ-VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD. [PDF]

JHEP Rep
Lin SZ, Xie Y, Cheng YQ, Xue R, Su YS, Liu M, Chen YW, Fan JG.   +7 more
europepmc   +1 more source

Repopulating Kupffer cells originate directly from hematopoietic stem cells. [PDF]

Stem Cell Res Ther, 2023
Fan X, Lu P, Cui XH, Wu P, Lin WR, Zhang D, Yuan SZ, Liu B, Chen FY, You H, Wei HD, He FC, Jia JD, Jiang Y.   +13 more
europepmc   +1 more source

Kupffer Cell Symposium [PDF]

The Bulletin of the Society of Pharmacological and Environmental Pathologists, 1977
openaire   +1 more source

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation. [PDF]

Adv Sci (Weinh)
Shi J, Li Q, Li J, Bai J, Xi J, He Q, Zhou J, Wang X, Song X, Li X, Yue X, Zhang X, Sun Z, Li J, Yang W, Cui Y, Shu W, Guo L, Wang S.   +18 more
europepmc   +1 more source