Results 141 to 150 of about 43,811 (246)

Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis

BioEssays, Volume 48, Issue 3, March 2026.
NLRP3, a cytosolic innate immune sensor, responds to diverse activators that perturb cellular homeostasis. These disturbances generate molecular scaffolds that, through binding partners such as nucleic acids, lipids, and proteins, recruit and concentrate NLRP3. Scaffold‐mediated NLRP3 clustering promotes NLRP3 inflammasome assembly.
Elvira Boršić‐Mlinarič, Iva Hafner‐Bratkovič   +1 more
wiley   +1 more source

Kupffer Cells Regulate iNKT Cells Through Il-12 to Mitigate the Extent of APAP-Induced Damage in the Liver. [PDF]

J Cell Mol Med
Li Y, Wen S, Liu J, Li S, Shi J, Wang H.
europepmc   +1 more source

Role of Kupffer cells in tolerance induction after liver transplantation. [PDF]

Front Cell Dev Biol, 2023
Zheng W, Yang L, Jiang S, Chen M, Li J, Liu Z, Wu Z, Gong J, Chen Y.   +8 more
europepmc   +1 more source

Burden of Liver Disease Among Individuals With Turner Syndrome and Klinefelter Syndrome: A Comprehensive Perspective

Chronic Diseases and Translational Medicine, Volume 12, Issue 1, Page 39-48, March 2026.
ABSTRACT The liver is increasingly recognized as a major regulator of systemic cardio‐renal‐metabolic health. Evidence is mounting that sex‐chromosome dosage per se itself, independent of gonadal sex hormones, modulates hepatic physiology and liver disease risk.
Mohamad Jamalinia, Amedeo Lonardo, Ralf Weiskirchen   +2 more
wiley   +1 more source

Axatilimab Immunogenicity and Clinical Relevance in Patients with Chronic Graft‐Versus‐Host Disease

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 791-801, March 2026.
Axatilimab, a monoclonal antibody targeting colony‐stimulating factor 1 (CSF‐1) receptor, is approved in the US for the treatment of chronic graft‐versus‐host disease (cGVHD) after failure of ≥2 lines of systemic therapy. In this study, the effects of antidrug antibody (ADA) status on the pharmacokinetics, pharmacodynamics, efficacy, and safety of ...
Yan‐ou Yang, Xing Liu, Breann Barker, Xuecheng Zhang, Peter Ordentlich   +4 more
wiley   +1 more source

Mannose-Conjugated Cholesterol Containing Lipid Nanoparticles for Active Targeted mRNA Delivery to Liver Sinusoidal Endothelial and Kupffer Cells. [PDF]

Bioconjug Chem
Kim Y, Chatterjee S, Robertson AL, Guerrero ED, Vaidya A, Wang X, Lee SM, Wei J, Miller WE, Farbiak L, Siegwart DJ.   +10 more
europepmc   +1 more source

Serum Inflammatory Markers and Dietary Inflammatory Index in Obese Individuals With Fatty Liver Disease: A Case–Control Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
Our findings underscore the role of inflammation in the pathophysiology of fatty liver disease among obese individuals. Elevated CRP levels highlight potential targets for intervention. ABSTRACT Background Fatty liver disease is common among obese individuals and is closely linked to chronic low‐grade inflammation.
Faezeh Tejareh, Laleh Payahoo, Seyed Ali Keshavarz   +2 more
wiley   +1 more source

Transcriptomic profiling of Kupffer cells exposed to <i>Clonorchis sinensis</i> extracellular vesicles: Unraveling the role of <i>CSF</i>3 in hepatic fibrosis. [PDF]

Food Waterborne Parasitol
Lan Z, Wang X, Zhang Y, Zhou L, Bai X, Zhang X, Zhang H, Qiu H, Gao J, Cheng G, Wang C.   +10 more
europepmc   +1 more source

Multi‐Target Mechanisms of Whey Protein Against NAFLD: Integrating Bile Acid Metabolism, Gut Microbiota and Hepatic Inflammation

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Whey protein (WP) alleviates high‐fat diet (HFD)‐induced nonalcoholic fatty liver disease (NAFLD) through a tripartite mechanism targeting the gut‐liver axis. (1) Gut Microbiota Modulation: WP restores intestinal flora homeostasis by enriching beneficial taxa (e.g., Lactobacillus) and increasing the production of short‐chain fatty acids (SCFAs).
Dongjin Xu, Biru Qiu, Xueyun Dong, Jiajun Tan, Yunhan Xie, Yuanyuan Wan, Chenghai Chu, Chunrun Miao, Asmaa Ali, Min Chen, Jiayuan He, Liang Wu, Jiayong Xie   +12 more
wiley   +1 more source

A Novel Function of Glycerol Kinase Alleviates LPS-Induced Inflammatory Responses by the p38/STAT3 Pathway and Mitigates ROS Generation in Kupffer Cells. [PDF]

Antioxidants (Basel)
Li Y, Zhang X, Wang D, Fan G, Yang X.
europepmc   +1 more source