Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]
Tsomidis I +3 more
europepmc +1 more source
Histiocytes: Multifaceted Regulators of Health and Disease
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Protocol for generating liver organoids containing Kupffer cells using human iPSCs. [PDF]
Li Y, Nie Y, Taniguchi H.
europepmc +1 more source
Abstract We tested whether older adults with well‐controlled type 2 diabetes or hypertension, compared with age‐matched adults without chronic disease, exhibit greater intestinal damage, microbial translocation and inflammation during exertional heat stress.
Ben J. Lee +8 more
wiley +1 more source
Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis. [PDF]
Zhang Y +15 more
europepmc +1 more source
Evaluation of Liver Damage and Herbal Detoxification of Coral Reef Fish Caused by Ammonia Stress
Slybum marianum can reduce ammonia stress and enhance liver protection in marine fish. ABSTRACT Ammonia nitrogen can cause serious toxicological damage to fish and cause fish death. This study focused on liver damage caused by ammonia nitrogen stress in coral reef fish and used herbal extracts to improve ammonia poisoning and prevent liver tissue ...
Wei‐Ting Sun +3 more
wiley +1 more source
DTX1-mediated degradation of TUBB3 in Kupffer cells mitigates hepatocellular carcinoma progression by regulating M1/M2 polarization. [PDF]
Sun J, Sun T, Zhang Y, Liu B, Yin L.
europepmc +1 more source
Exploring the Lung–Liver Axis in Pulmonary Arterial Hypertension
Among PAH patients without liver disease, subclinical liver dysfunction quantified by MELD‐Na associates with higher pulmonary vascular resistance and inflammatory activation of the pulmonary endothelium, characterized by an IL‐6‐centered transcriptional network enriched for leukocyte chemotaxis.
Navneet Singh +21 more
wiley +1 more source

