Results 161 to 170 of about 45,372 (255)

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis. [PDF]

Exp Mol Med
Park JS, Lee J, Wang F, Ma H, Zhou Z, Lee YS, Oh K, Lee H, Sui G, Lee S, Yang YM, Lee JW, Ji YH, Park CW, Yoo HS, Hwang BY, Han SB, Song N, Oh S, Kim B, Seki E, Hong JT, Roh YS.   +22 more
europepmc   +1 more source

The Six Pillars of Lifestyle Medicine in MASLD: An Evidence‐Based Guide

Liver International Communications, Volume 7, Issue 3, September 2026.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and is projected to affect more than 40% of adults by 2050. Although pharmacologic therapies are emerging, lifestyle modification remains the foundation of management.
Jigyasa Sharma, Kathleen Viveiros
wiley   +1 more source

The role of Kupffer cells in microbiota-brain communication: Sleep and fever signaling in response to lipopolysaccharide. [PDF]

Brain Behav Immun
Szentirmai É, Buckley K, Kapás L.
europepmc   +1 more source

Impact of Regional Hepatic Immunosuppression With Budesonide on Bacterial Elimination in Porcine Abdominal Sepsis

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Introduction The liver is essential for bacterial elimination, preventing intestinal bacteria from entering the systemic circulation, and for producing inflammatory cytokines. Glucocorticoids have been reported to exert heterogeneous effects on bacterial clearance in sepsis.
Katja Hanslin, Paul Skorup, Frida Wilske, Anders Larsson, Eva Tano, Jan Sjölin, Miklos Lipcsey   +6 more
wiley   +1 more source

Inhibitor of differentiation 3 confers the robust anti-tumor activity of Kupffer cells. [PDF]

MedComm (2020)
Ren J, Liu S, Zhang L.
europepmc   +1 more source

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga, Silvia Frigo, Alessandro Cherubini, Eniada Rrapaj, Luca Valenti   +4 more
wiley   +1 more source

Kupffer Cells and Hepatocytes: A Key Relation in the Context of Canine Leishmaniasis. [PDF]

Microorganisms
Rodrigues A, Alexandre-Pires G, Valério-Bolas A, Nunes T, Pereira da Fonseca I, Santos-Gomes G.   +5 more
europepmc   +1 more source

Time‐Varying Impact of Steatosis and Alcohol on Mortality: A Marginal Structural Model of the Canadian Longitudinal Study on Aging

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Background and Aims Subclassifications of steatotic liver disease (SLD) are intended to provide a clinically meaningful framework for management. However, steatosis, cardiometabolic comorbidities and alcohol consumption are known to change over time.
Carmela Rapino, Giada Sebastiani, Jessica Burnside, Cindy Wen, Alnoor Ramji, Mark Swain, Keyur Patel, Sahar Saeed   +7 more
wiley   +1 more source

[Role of Kupffer cells in liver regeneration with metabolic associated fatty liver disease in mice]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Wang TW, Liu L, Wang SY, Cheng LL, Wang X, Cao YN, Wang YF, Yang LM.   +7 more
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, Volume 13, Issue 44, 7 August 2026.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source