Results 171 to 180 of about 45,372 (255)

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCε/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells. [PDF]

Inflammation
Li Y, Kuang H, Fan G, Yang X.
europepmc   +1 more source

Clonal Hematopoiesis in Colorectal Cancer: Mechanisms and Implications

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Clonal hematopoiesis (CH) arises from the expansion of hematopoietic stem and progenitor cells bearing somatic mutations, often in genes linked to epigenetic regulation and inflammation. Once considered a benign age‐related phenomenon, CH has gained increasing attention for its potential to influence cancer biology beyond hematologic ...
Chenyue Xia, Yi Lu, Jinhui Gu
wiley   +1 more source

Protocol for isolating CD163⁺ Kupffer cells from human liver resections. [PDF]

STAR Protoc
Roca Suarez AA, Plissonnier ML, Michelet M, Dubois A, Heintz S, Saez-Palma M, Delphin M, Bordes I, Molle J, Diederichs A, Rodà M, Combe E, Mougené L, Giraud G, Grand X, Rivoire M, Levrero M, Testoni B, Zoulim F.   +18 more
europepmc   +1 more source

Comprehensive Pan‐Cancer Analysis of ABCA1: Insights From Multi‐Omics Data and Exploratory Validation in Esophageal Squamous Cell Carcinoma

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Cancer remains a major cause of global mortality, necessitating the identification of novel biomarkers to improve prognosis and guide therapy. ABCA1, an ATP‐binding cassette transporter involved in cholesterol efflux, has been implicated in tumorigenesis, yet its pan‐cancer roles and clinical relevance are not fully understood.
Chenyang Wang, Hanbing Wang, Xi Chen, Yingying Liu, Lili Duan, Zhenshun Li, Liaoran Niu, Aqiang Fan, Siyu Wei, Han Bai, Yujie Zhang, Wei Zhou, Jinqiang Liu, Wanli Yang, Yu Han, Liu Hong, Daiming Fan   +16 more
wiley   +1 more source

Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells. [PDF]

Nat Commun
Huang HY, Chen YZ, Zhao C, Zheng XN, Yu K, Yue JX, Ju HQ, Shi YX, Tian L.   +8 more
europepmc   +1 more source

The Postprandial Chronobiome in Interorgan Glucose Homeostasis

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
The postprandial chronobiome framework proposes that meal‐timed oscillations in microbial communities and metabolites may interact with host tissue clocks to shape glucose handling. The liver is the best‐supported temporal interpreter, while phase‐aware human studies are needed to establish causal interorgan effects.
Josko Bozic, Roko Santic, Marko Kumric
wiley   +1 more source

Gram-negative bacteria-driven increase of cytosolic phospholipase A2 leads to activation of Kupffer cells. [PDF]

Cell Mol Life Sci
Lin H, Wieser A, Zhang J, Regel I, Nieß H, Mayerle J, Gerbes AL, Liu S, Steib CJ.   +8 more
europepmc   +1 more source

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
SLC7A5‒Kyn/XANA signalling activates AhR to drive EMT and metastatsis. SLC7A5 knockdown enhances macrophage antigen presentation and reverses CD8+ T‐cell exhaustion. SLC7A5 knockdown induces antigen‐driven and IgG‐secreting B‐cell clonal expansion. Combination of SLC7A5 inhibition and anti‐PD‐1 therapy offers clinical targeting.
Yaohao Luo, Lei Li, Shanbao Li, Xinshuai Wang, Zeping He, Fangbin Song, Jun Qin, Jinyan Zhang, Junming Xu   +8 more
wiley   +1 more source