Results 191 to 200 of about 50,401 (271)

Sex‐specific hepatic effects of sweetened alcohol consumption and tannic acid intervention in adolescent rats

Physiological Reports, Volume 14, Issue 13, July 2026.
Abstract This study investigated the combined effects of alcohol and sugar, termed sweetened alcohol consumption (SAC), and tannic acid (TA) intervention on hepatic health in adolescent rats. Sixty‐four male and female 42‐day‐old Sprague–Dawley rats were assigned to control, TA (50 mg/kg), SAC (10% ethanol +20% fructose), or SAC+TA groups and treated ...
Toluwase E. Olanipekun, Oladiran I. Olateju, Monica Gomes, Ashmeetha Manilall, Kennedy H. Erlwanger   +4 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Elucidates the Progressive Disease Landscape and Reveals Dynamic Protein Biomarkers for MASLD Surveillance

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Integrated transcriptomic, single‐cell, pseudotime, cell–cell communication, human tissue, and in vivo analyses define a dynamic four‐gene axis across the MASLD continuum. Progressive CYP2C19 downregulation and AKR1B10, COL1A2, and SPP1 upregulation link metabolic dysfunction to disease progression, while AKR1B10 knockdown or CYP2C19 overexpression ...
Kejun Liu, Bozhi Zhang, Yezhen Tang, Zhenyao Tan, Yang Bu, Yongxue Lv   +5 more
wiley   +1 more source

CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation. [PDF]

Adv Sci (Weinh)
Shi J, Li Q, Li J, Bai J, Xi J, He Q, Zhou J, Wang X, Song X, Li X, Yue X, Zhang X, Sun Z, Li J, Yang W, Cui Y, Shu W, Guo L, Wang S.   +18 more
europepmc   +1 more source

Mannose-Conjugated Cholesterol Containing Lipid Nanoparticles for Active Targeted mRNA Delivery to Liver Sinusoidal Endothelial and Kupffer Cells. [PDF]

Bioconjug Chem
Kim Y, Chatterjee S, Robertson AL, Guerrero ED, Vaidya A, Wang X, Lee SM, Wei J, Miller WE, Farbiak L, Siegwart DJ.   +10 more
europepmc   +1 more source

Transcriptomic profiling of Kupffer cells exposed to <i>Clonorchis sinensis</i> extracellular vesicles: Unraveling the role of <i>CSF</i>3 in hepatic fibrosis. [PDF]

Food Waterborne Parasitol
Lan Z, Wang X, Zhang Y, Zhou L, Bai X, Zhang X, Zhang H, Qiu H, Gao J, Cheng G, Wang C.   +10 more
europepmc   +1 more source

A Novel Function of Glycerol Kinase Alleviates LPS-Induced Inflammatory Responses by the p38/STAT3 Pathway and Mitigates ROS Generation in Kupffer Cells. [PDF]

Antioxidants (Basel)
Li Y, Zhang X, Wang D, Fan G, Yang X.
europepmc   +1 more source

Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells. [PDF]

Nat Commun
Yang K, Kim K, Ryu T, Shim YR, Kim HH, Choi SE, Kim MJ, Chung KPS, Lee E, Lee KW, Jeon J, Kim P, Kim YS, Ku T, Jeong H, Nam KT, Lim G, Choi DW, Kim SH, Eun HS, Kim W, Jeong WI.   +21 more
europepmc   +1 more source

Breast cancer induces CD62L⁺ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis. [PDF]

Cell Discov
Tian P, Wu Q, He D, Zhao W, Luo L, Jia Z, Luo W, Lv X, Liu Y, Wang Y, Wang Q, Zhang P, Liang Y, Yang Q, Hu G.   +14 more
europepmc   +1 more source

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis. [PDF]

Exp Mol Med
Park JS, Lee J, Wang F, Ma H, Zhou Z, Lee YS, Oh K, Lee H, Sui G, Lee S, Yang YM, Lee JW, Ji YH, Park CW, Yoo HS, Hwang BY, Han SB, Song N, Oh S, Kim B, Seki E, Hong JT, Roh YS.   +22 more
europepmc   +1 more source

[Role of Kupffer cells in liver regeneration with metabolic associated fatty liver disease in mice]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Wang TW, Liu L, Wang SY, Cheng LL, Wang X, Cao YN, Wang YF, Yang LM.   +7 more
europepmc   +1 more source