Results 191 to 200 of about 74,691 (293)

Impact of Underlying Liver Disease on the Risk and Prognostic Factors of Breast Cancer Liver Metastases: A Retrospective Multicenter Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective To examine factors influencing breast cancer liver metastases (BCLM) and assess the impact of underlying liver diseases (nonalcoholic fatty liver and HBsAg infection) on BCLM development. Methods Patients diagnosed with breast cancer at four affiliated hospitals in China between 2014 and 2024 were included.
Xiaowen Wang, Yuan Zhang, Qiwei Yang, Luo Yang, Yanhui Wang, Xiangxin Zeng, Long Zou, Yujuan Guo, Wenyang Zhou, Yuqi Jiang, Jiezhong Wu, Peng Zhang, Song Zhou, Guangjuan Zheng, Tao Huang, Genshu Wang, Kunpeng Hu   +16 more
wiley   +1 more source

Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells. [PDF]

Nat Commun
Yang K, Kim K, Ryu T, Shim YR, Kim HH, Choi SE, Kim MJ, Chung KPS, Lee E, Lee KW, Jeon J, Kim P, Kim YS, Ku T, Jeong H, Nam KT, Lim G, Choi DW, Kim SH, Eun HS, Kim W, Jeong WI.   +21 more
europepmc   +1 more source

Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
FGF10‐FGFR2 signaling is progressively impaired during liver fibrosis. FGF10 restoration protects hepatocytes from inflammatory and apoptotic injury. Hepatocyte FGFR2 mediates FGF10‐driven suppression of fibrogenic remodeling through the GSK3β/NF‐κB axis.
Xuanxin Yang, Qingqing Dong, Jiaying Ma, Yawei Yan, Shuangyan Peng, Qiqi Wu, Huan Wang, Tingting Zhang, Panyu Zhang, Zelong Jiang, Chao Lu, Le Li, Xinyi You, Yuandong Xu, Joshua Banda, Zhixiang Mu, Minghua Zheng, Xiaokun Li, Qi Hui, Bingjie Yu, Xiaojie Wang   +20 more
wiley   +1 more source

Breast cancer induces CD62L⁺ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis. [PDF]

Cell Discov
Tian P, Wu Q, He D, Zhao W, Luo L, Jia Z, Luo W, Lv X, Liu Y, Wang Y, Wang Q, Zhang P, Liang Y, Yang Q, Hu G.   +14 more
europepmc   +1 more source

Melatonin and Quercetin Co‐Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
Quercetin and melatonin, alone or combined, effectively protect the liver in diabetic rats. The antioxidants reduce hyperglycemia, oxidative stress, and inflammation, preventing hepatic damage. ABSTRACT Liver complications in diabetes are very common, contributing to a high mortality rate, making it essential to develop strategies to minimize this ...
Érique Ricardo Alves, Jaiurte Gomes Martins da Silva, Ismaela Maria Ferreira de Melo, Laís Caroline da Silva Santos, Marcelle Mariana Sales de França, Clovis Lapa Neto, Vanessa Bischoff Medina, Francisco de Assis Leite Souza, Leucio Duarte Vieira, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +10 more
wiley   +1 more source

[Role of Kupffer cells in liver regeneration with metabolic associated fatty liver disease in mice]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Wang TW, Liu L, Wang SY, Cheng LL, Wang X, Cao YN, Wang YF, Yang LM.   +7 more
europepmc   +1 more source

Ergothioneine Ameliorates Alcoholic Fatty Liver Disease: A Dual Strategy of Accelerated Ethanol Elimination and Reducing Oxidative Stress

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
Ergothioneine (EGT) ameliorates alcoholic fatty liver disease via a dual mechanism: accelerating ethanol clearance by protecting ADH/ALDH activity (serum EtOH decreased 54.4%), and reducing oxidative stress/inflammation via antioxidant restoration (GSH‐Px increased 198.2%) and NF‐κB suppression (IL‐1β decreased 67.1%), collectively reversing hepatic ...
Wei Ding, Juan Cao, Cong Guo, Xu Li, Wei Liu, Guohua Xiao   +5 more
wiley   +1 more source

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis. [PDF]

Exp Mol Med
Park JS, Lee J, Wang F, Ma H, Zhou Z, Lee YS, Oh K, Lee H, Sui G, Lee S, Yang YM, Lee JW, Ji YH, Park CW, Yoo HS, Hwang BY, Han SB, Song N, Oh S, Kim B, Seki E, Hong JT, Roh YS.   +22 more
europepmc   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

The role of Kupffer cells in microbiota-brain communication: Sleep and fever signaling in response to lipopolysaccharide. [PDF]

Brain Behav Immun
Szentirmai É, Buckley K, Kapás L.
europepmc   +1 more source