Results 211 to 220 of about 74,691 (293)

Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging

Aging Cell, Volume 25, Issue 5, May 2026.
T cells are the most dynamically altered immune population in the aged liver. Accumulation of CD8+ Tex in aged livers. Spatial enrichment of CD8+ Tex in the portal vein zone. PP hepatocytes promote T cell exhaustion via Lpin1. T cell exhaustion correlates with liver disease progression.
Jiahua Lu, Yuqian Wang, Wenxue Zhao, Zihao Zhao, Zhaoya Gao, Jin Gu, Cheng Li, Jie Cheng   +7 more
wiley   +1 more source

Gram-negative bacteria-driven increase of cytosolic phospholipase A2 leads to activation of Kupffer cells. [PDF]

Cell Mol Life Sci
Lin H, Wieser A, Zhang J, Regel I, Nieß H, Mayerle J, Gerbes AL, Liu S, Steib CJ.   +8 more
europepmc   +1 more source

Metabolic studies following orthotopic liver transplantation [PDF]

, 1971
Starzl, TE
core  

Preoperative Beta‐Hydroxy‐Beta‐Methyl‐Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim The liver exhibits a remarkable regenerative capacity, enabling this organ to maintain homeostasis even after significant injury. However, hepatic regeneration requires sufficient energy to sustain cellular hypertrophy and proliferation, thus ensuring efficient tissue repair.
A. L. Vieira‐da‐Silva, M. V. Esteca, F. A. Silva, I. A. Divino, F. S. Carneiro, E. R. Ropelle, A. S. Torsoni, I. L. Baptista   +7 more
wiley   +1 more source

Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells. [PDF]

Nat Commun
Huang HY, Chen YZ, Zhao C, Zheng XN, Yu K, Yue JX, Ju HQ, Shi YX, Tian L.   +8 more
europepmc   +1 more source

Studies of homograft sex and of gamma globulin phenotypes after orthotopic homotransplantation of the human liver. [PDF]

, 1969
Brettschneider, L, Kashiwagi, N, Penn, I, Porter, KA, Starzl, TE   +4 more
core  

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. [PDF]

J Exp Med
Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K.   +26 more
europepmc   +1 more source

Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers

Cancer Science, Volume 117, Issue 5, Page 1209-1222, May 2026.
Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu, Mengzhu Chinn, Feng Chen, Yerkezhan Yerkinkazhina, Yuan Tian, Wei‐Guo Zhu   +5 more
wiley   +1 more source

Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development. [PDF]

Nat Commun
Fima R, Dussaud S, Benbida C, Blanchet M, Lanthiez F, Poupel L, Brambilla C, Gélineau A, Dessena M, Blanc M, Lerévérend C, Moreau M, Boissonnas A, Gautier EL, Huby T.   +14 more
europepmc   +1 more source