Results 151 to 160 of about 2,282 (189)

<i>KCNQ2</i> Variants in Neonatal Epilepsy: Clinical Characteristics and Neurodevelopmental Outcomes in 30 Patients. [PDF]

Neurol Genet
Li Y, Li J, Li L, Zhang H, Sun X.
europepmc   +1 more source

Voltage-gated potassium channels as important modulators of glucose-stimulated insulin secretion in pancreatic β-cells: insights from rodent and human studies. [PDF]

Front Endocrinol (Lausanne)
Xing JJ, Chen C.
europepmc   +1 more source

SphereChip attaches spheroids and organoids to planar multielectrode arrays with microfluidics.

Lab Chip
Hoebart C, Lux M, Beyl S, Baltov B, Hering S.   +4 more
europepmc   +1 more source

Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites

Current Medicinal Chemistry, 2018
Background: The Kv7 (KCNQ) subfamily of voltage-gated potassium channels consists of 5 members (Kv7.1-5) each showing characteristic tissue distribution and physiological roles. Given their functional heterogeneity, Kv7 channels represent important pharmacological targets for the development of new drugs for neuronal, cardiovascular and metabolic ...
Francesco Miceli, Paolo Ambrosino, Maurizio Taglialatela   +2 more
exaly   +6 more sources

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Cooperativity between calmodulin-binding sites in Kv7.2 channels

Journal of Cell Science, 2013
Summary Among the multiple roles assigned to calmodulin (CaM), controlling the surface expression of Kv7.2 channels by binding to two discontinuous sites is a unique property of this Ca2+ binding protein. Mutations that interfere with CaM binding or the sequestering of CaM prevent this M-channel component from exiting the endoplasmic ...
Alaimo A., Alberdi A., Gomis-Perez C., Fernandez-Orth J., Gomez-Posada J. G., Areso P., Villarroel A.   +6 more
openaire   +2 more sources

Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype

Bioorganic & Medicinal Chemistry Letters, 2022
To identify pore domain ligands on Kv7.2 potassium ion channels, we compared wild-type (WT) and W236L mutant Kv7.2 channels in a series of assays with previously validated and novel agonist chemotypes. Positive controls were retigabine, flupirtine, and RL-81; i.e.
Ciria C, Hernandez, Rahilla A, Tarfa, Jose, Miguel I Limcaoco, Ruiting, Liu, Pravat, Mondal, Clare, Hill, R, Keith Duncan, Thanos, Tzounopoulos, Corey R J, Stephenson, Matthew J, O'Meara, Peter, Wipf   +10 more
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Amitriptyline Is a Potent Blocker of Human Kv1.1 and Kv7.2/7.3 Channels

Anesthesia & Analgesia, 2007
Kv1.1 and Kv7.2/7.3 channels control excitability of neuronal cells. As hyperexcitability is a sign of neuropathic pain, epilepsy, and anxiety disorders, these channels may be important molecular targets of amitriptyline that cause pharmacological as well as toxicological effects by altering neuronal excitability.
Mark A, Punke, Patrick, Friederich
openaire   +2 more sources

Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy

Epilepsia, 2018
SummaryObjectiveTo gain insight into the mechanisms underlying KCNQ2 encephalopathy by examining the electrophysiologic properties of mutant Kv7.2 channels in different multimeric configurations.MethodsWe analyzed the genotype‐phenotype relationship in 4 patients with KCNQ2 encephalopathy and performed electrophysiologic analysis of M‐currents mediated
Carolina Gomis‐Pérez, Janire Urrutia, Anna Marcé‐Grau, Covadonga Malo, Eduardo López‐Laso, Ana Felipe‐Rucián, Miquel Raspall‐Chaure, Alfons Macaya, Alvaro Villarroel   +8 more
openaire   +3 more sources

Discovery of a novel KV7.2/7.3 channels agonist for the treatment of neuropathic pain

European Journal of Medicinal Chemistry
Here, we designed, synthesized and evaluated a series of compounds as KV7.2/7.3 channels (or KCNQ2/3) agonists. The new compounds were assayed in vitro for KCNQ2/3 and other receptors binding affinity. The desired compound 16 showed high activity for KCNQ2/3 (EC50 = 1.03 ± 0.07 μM) without acute liver injury compared to flupirtine.
Kun Qian, Jingyan Zhou, Jiaying Xiong, Qing Wang, Ling Chen, Tao Zhuang, Jian Jin, Guisen Zhang, Chao Hao, Ling Huang, Yin Chen   +10 more
openaire   +2 more sources

Genetic features and pharmacological rescue of novel Kv7.2 variants in patients with epilepsy

Journal of Medical Genetics
Background Increasing evidence indicates a robust correlation between epilepsy and variants of the Kv7.2 ( KCNQ2 ) channel, which is critically involved in directing M-currents and regulating neuronal excitability within the nervous system.
Yue Song, Yang Xia, Ziyue Peng, Yuhuan Meng, Wenwen Jing, Li Xie, Tianhua Cao, Jiahui Zhang, Huilin Song, Lingdi Meng, Yi Zhang, Shengbin Sui, Di Mao, Ying Jia, Shupei Qiao, Shihui Yu, Xue Zhang   +16 more
openaire   +2 more sources