Results 121 to 130 of about 1,204,901 (187)

Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements after hemorrhagic shock in rats

, 2017
Background Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether Kv7 channel inhibitors can be utilized to stabilize hemodynamics and reduce ...
Nassoiy, Sean, Byron, Kenneth, Majetschak, Matthias   +2 more
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Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine. [PDF]

Neuroscience, 2019
Feng M, Crowley NA, Patel A, Guo Y, Bugni SE, Luscher B.   +5 more
europepmc   +1 more source

Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells. [PDF]

iScience
Zhou Z, Gong M, Pande A, Margineanu A, Lisewski U, Purfürst B, Zhu H, Liang L, Jia S, Froehler S, Zeng C, Kühnen P, Khodaverdi S, Krill W, Röpke T, Chen W, Raile K, Sander M, Izsvák Z.   +18 more
europepmc   +1 more source

Effects of the KCNQ (Kv7) Channel Opener Ezogabine on Resting-State Functional Connectivity of Striatal Brain Reward Regions, Depression, and Anhedonia in Major Depressive Disorder: Results From a Randomized Controlled Trial. [PDF]

Biol Psychiatry
Chowdhury A, Boukezzi S, Costi S, Hameed S, Jacob Y, Salas R, Iosifescu DV, Han MH, Swann A, Mathew SJ, Morris L, Murrough JW.   +11 more
europepmc   +1 more source

Cardiovascular Kv7 channels in health and in disease

, 2015
Els canals de potassi dependents de voltatge Kv7.1 i Kv7.5 juguen un paper molt important en la fisiologia del sistema cardiovascular. Aquest canals iònics estan formats per la tetramerització de 4 subunitats α. La heterotetramerizació és un dels mecanisme principals que dona lloc a la immensa diversitat funcional que mostra aquesta família.
openaire   +1 more source

GYY4137 and Sodium Hydrogen Sulfide Relaxations Are Inhibited by L-Cysteine and K_V7 Channel Blockers in Rat Small Mesenteric Arteries. [PDF]

Front Pharmacol, 2021
Abramavicius S, Petersen AG, Renaltan NS, Prat-Duran J, Torregrossa R, Stankevicius E, Whiteman M, Simonsen U.   +7 more
europepmc   +1 more source

A Novel Compound QO-83 Alleviates Acute and Chronic Epileptic Seizures in Rodents by Modulating K_V7 Channel Activity. [PDF]

CNS Neurosci Ther
Wang X, Zhang Y, Liu H, Wang J, Zhang B, He T, Zhang H, Xiong Z, Liu X, Li J, Zhao W, Liu X, Zhang W, Yang L, Li Q, Zhang H, Qi J, Jia Q.   +17 more
europepmc   +1 more source

K_v7 channel opener retigabine reduces self-administration of cocaine but not sucrose in rats. [PDF]

Addict Biol
Urena ES, Diezel CC, Serna M, Hala'ufia G, Majuta L, Barber KR, Vanderah TW, Riegel AC.   +7 more
europepmc   +1 more source

The Kv7 channel activator, retigabine, induces vasorelaxation via an endothelial-independent pathway in male mouse aorta. [PDF]

J Exerc Nutrition Biochem, 2018
Namgoong H, Cho C, Lee S.
europepmc   +1 more source

Genetic and pharmacological studies of KV7 channels in excitability disorders

The KV7 (KCNQ) subfamily of voltage-gated potassium channels plays a key role in the regulation of neuronal excitability. By controlling the neuronal M-current, KV7 channels represent pharmacological targets for neurological disorders characterized by ...
LUZIO GASPAR, INGRIDE
core