Results 111 to 120 of about 1,204,901 (187)

KCNQ channels regulate age-related memory impairment:KCNQ regulates age-related memory [PDF]

, 2013
In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and
Bilal R Malik, Malik, Bilal R., Cavaliere, Sonia, Malik, Bilal R, Bilal R. Malik (408687), James J. L. Hodge, Sonia Cavaliere, James J. L. Hodge (116854), Bilal R. Malik, Hodge, James J. L., James J L Hodge, Sonia Cavaliere (116850), Hodge, James J L   +12 more
core   +1 more source

Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension. [PDF]

Cardiovasc Res, 2022
Sheng ZF, Zhang H, Zheng P, Chen S, Gu Z, Zhou JJ, Phaup JG, Chang HM, Yeh ETH, Pan HL, Li DP.   +10 more
europepmc   +1 more source

Kv7 channel trafficking by the microtubule network in vascular smooth muscle. [PDF]

Acta Physiol (Oxf), 2021
Jepps TA.
europepmc   +1 more source

Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity. [PDF]

J Med Chem, 2022
Musella S, Carotenuto L, Iraci N, Baroli G, Ciaglia T, Nappi P, Basilicata MG, Salviati E, Barrese V, Vestuto V, Pignataro G, Pepe G, Sommella E, Di Sarno V, Manfra M, Campiglia P, Gomez-Monterrey I, Bertamino A, Taglialatela M, Ostacolo C, Miceli F.   +20 more
europepmc   +1 more source

Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain

Molecular Pain, 2019
Neuropathic pain conditions severely and chronically affect the quality of life in a large human population, but the pain conditions are not adequately managed due to poor understanding of their underlying mechanisms. There is a pressing need for further
Alaa Abd-Elsayed, Markus Jackson, Steven L Gu, Kenneth Fiala, Jianguo Gu   +4 more
doaj   +1 more source

KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission

, 2006
Synchronous neuronal firing can be induced in hippocampal slices in the absence of synaptic transmission by lowering extracellular Ca2+ and raising extracellular K+.
PICCININ, Sonia, J. T. Brown, Randall, AD, A. D. Randall, Brown, JT, Piccinin, S   +5 more
core   +1 more source

Participation of calcium-permeable AMPA receptors in the regulation of epileptiform activity of hippocampal neurons

Frontiers in Synaptic Neuroscience
IntroductionEpileptiform activity is the most striking result of hyperexcitation of a group of neurons that can occur in different brain regions and then spread to other sites.
Valery Petrovich Zinchenko, Ilia Yu. Teplov, Artem Mikhailovich Kosenkov, Sergei Gennadievich Gaidin, Bakytzhan Kairatuly Kairat, Sultan Tuleukhanovich Tuleukhanov   +5 more
doaj   +1 more source

Physiological and pharmacological modulation of Kv7 channels

, 2017
Voltage-dependent potassium channels are spanning-membrane integral proteins involved in several and diverse physiological and pathological processes such as immune response or cardiovascular function. The first goal of this study was to elucidate the role of KV7.1/KV7.5, as a heterotetramer complex, in vascular smooth muscle.
openaire   +3 more sources

Discovery of a potent, Kv7.3-selective potassium channel opener from a Polynesian traditional botanical anticonvulsant

Communications Chemistry
Plants remain an important source of biologically active small molecules with high therapeutic potential. The voltage-gated potassium (Kv) channel formed by Kv7.2/3 (KCNQ2/3) heteromers is a major target for anticonvulsant drug development.
Geoffrey W. Abbott, Rían W. Manville
doaj   +1 more source

Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology [PDF]

Frontiers in Physiology, 2021
Jepps, Thomas A, Barrese, Vincenzo, Miceli, Francesco   +2 more
openaire   +6 more sources